Chronotoxicity of Nedaplatin in Rats

Cui, Yu Xin; Sugimoto, Koh‐ichi; Kawai, Yoshiko; Sudoh, Toshiaki; Gemba, Munekazu; Fujimura, Akio

doi:10.1081/cbi-120039814

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…In contrast, nocturnally active rats as well as night shift workers were apparently little affected (Brelis, 1984). Circadian rhythmicity in host tolerance to, and toxicity of, chemical agents was first documented in laboratory experiments almost 50 yrs ago; more recent examples include ketamine/midazolam (Rebuelto et al, 2005), nedaplatin (Cui et al, 2004), irinotecan (Filipski et al, 2004), alcohol (Danel and Touitou, 2004), loratadine (Dridi et al, 2005), and morphine (Cui et al, 2005). The hypothesis of the MIC chronotoxic effect, however, has never been tested.…”

Section: Introductionmentioning

confidence: 96%

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Sani¹,

Gadacha²,

Boughattas

et al. 2006

Chronobiology International

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Thiosulfate sulfurtransferase (TST) is an important 'enzyme of protection,' that accelerates the detoxification of cyanide, converting it into thiocyanate. The TST physiological rhythm was investigated at wks 2, 4, and 8 of post-natal development (PND) in the mouse. The results revealed a statistically significant gender-related difference, with the highest activity in females, at all the documented PND stages. In the second week of PND (pre-weaning time), the circadian rhythm of the enzyme activity was associated with ultradian components. The prominent circadian rhythm (tau=24 h) peaked at the beginning of the light span, more precisely approximately 3 HALO (Hours After Light Onset). A week after weaning (wk 4 of PND), an impairment of the rhythm, with the peak shifted toward the second half of photophase, was recorded. Four to 6 wks later, about wk 8 of PND, the circadian rhythm pattern was stabilized, with its peak then located at the beginning of the dark span (13 HALO). The obtained results showed a 12 h phase-shift of the circadian TST peak time during PND, suggesting that the rhythm stabilization is age-dependent.

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Section: Introductionmentioning

confidence: 96%

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Sani¹,

Gadacha²,

Boughattas

et al. 2006

Chronobiology International

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“…Recently, Cui et al have demonstrated that a correlation is detected between content of platinum in the renal cortex and nephrotoxicity induced by nedaplatin. 19) However, there is no report of the relationship accumulation of cisplatin and nedaplatin in the kidney to their nephtoroxicity.…”

Section: -7)mentioning

confidence: 99%

Relationship between Cisplatin or Nedaplatin-Induced Nephrotoxicity and Renal Accumulation

Kawai

Taniuchi

Okahara

et al. 2005

Biological & Pharmaceutical Bulletin

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Nedaplatin is known to exhibit antitumor activity similar to that of cisplatin. However, concerning side effects, nedaplatin causes renal toxicity less frequently than cisplatin. In this study, we compared the incidence of renal toxicity between cisplatin and nedaplatin by investigating the difference in kidney tissue accumulation. Kidney tissue accumulation of cisplatin administered at 3.75 mg/kg was similar to that of nedaplatin administered at 24 mg/kg. At these doses, the plasma creatinine level and urinary excretion of glucose and N-acetyl-b b-D-glucosaminidase (NAG) similarly increased. There was a correlation between kidney accumulation of cisplatin and nedaplatin and the increases in plasma creatinine level and urinary excretion of NAG. Therefore, our results suggest that nedaplatin less frequently causes renal toxicity in comparison to cisplatin due to lower kidney accumulation.

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“…This has been demonstrated by a large number of chronotoxicology modeling experiments done on laboratory animals as well as clinical studies conducted on male and female cancer patients. [35][36][37][38][39][40] It is of interest that the initial clinical chronotoxicology trial of cancer medications was done on women 20 years ago by Hrushesky. 35 The purpose of this groundbreaking research was to determine if the toxicity of the first-line cancer medications, doxorubicin and cisplatin, used to treat bladder and gynecological malignancies could be significantly attenuated by infusing them to circadian rhythms.…”

Section: Smolensky Et Al 40mentioning

confidence: 99%

Biological Rhythms, Medication Safety, and Women's Health

Smolensky

Hermida²,

Haus³

et al. 2005

Journal of Women's Health

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Biological processes and functions in women are well organized in time, as evidenced by the expression of ultradian (high frequency), circadian ( approximately 24-hour), circamensual ( approximately monthly), and circannual ( approximately yearly) rhythms and by the changes that occur with menarche, reproduction, and menopause. Attributes of women's circamensual structure have been explored in depth, particularly with regard to fertility/infertility and birth control. However, the role of 24-hour and other rhythms in health, disease, and treatment has been little studied. The symptom intensity of a variety of chronic medical conditions is rhythmic, as is the risk of severe events, such as stroke and myocardial infarct (MI). Improving the safety, efficacy, and preventive qualities of medications requires the understanding of how rhythms impact drug pharmacokinetics and pharmacodynamics. The therapeutic and adverse effects of prescription and nonprescription medications widely used by women can vary markedly with the (circadian) time of administration. Circadian rhythm-dependent differences in the safety of medications are particularly relevant to pregnant women; laboratory animal studies show that the fetal toxicity of various treatments varies not only with developmental stage but also with circadian time. Rhythm-dependent differences in the actions of medications are also of great importance to perimenopausal and postmenopausal women, who are advised to ingest prescribed pharmacotherapy for osteopenia and osteoporosis in the morning to minimize the risk of adverse effects and, as a consequence, may elect to take other medications at times not recommended in the instructions for their use. Medication trials must be comprehensive and representative of women and men of different life stages, ethnicities, and likely times (morning vs. evening) of drug use.

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Chronotoxicity of Nedaplatin in Rats

Cited by 13 publications

References 13 publications

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Circadian and Ultradian (12 H) Rhythms of Hepatic Thiosulfate Sulfurtransferase (Rhodanese) Activity in Mice During the First Two Months of Life

Relationship between Cisplatin or Nedaplatin-Induced Nephrotoxicity and Renal Accumulation

Biological Rhythms, Medication Safety, and Women's Health

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