Chronotypes and oxidative stress: is there an association?

Abstract

Human studies suggest that free radicals and antioxidant enzymes can alter according to age, lifestyle, environment, and habits. Individuals having a marked circadian preference, that is, morning type or evening type, differ on a number of psychological, behavioral, and biological variables. The aim of this study was to determine whether chronotype impacts some parameters of oxidant and antioxidant status. For this purpose, glutathione peroxidase (GSH-P x ), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and the levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 96 healthy volunteers (including 32 morning-type, 32 intermediate-type, and 32 evening-type individuals), aged between 21 and 26 years. There were no significant relationships between the chronotypes with regard to oxidant and antioxidant parameters. Our results indicated that the levels of GSH and MDA as well as the activities of GSH-P x , MPO, and SOD were not influenced by the individual circadian differences in our sample. These results were discussed using the theoretical concepts of age-related factors, and suggestions for further research presented.

Comparison of Superoxide Dismutase, Glutathione Peroxidase and Adenosine Deaminase Activities between Respiratory and Nocturnal Subtypes of Patients with Panic Disorder

“…Whole blood samples were hemolyzed with deionized water. After centrifugation (4,000 g for 10 min at +4°C), upper supernatant fluid was separated, and SOD, GSH-Px and ADA activities were measured at this stage, consistent with the method used by Selvi et al [33]. The activities of these enzymes were also determined in serum.…”

Chronobiology and Mood Disorders

“…Ülkemizde kronobiyoloji ve psikiyatrik bozukluklar ilişkisine dair ilgi hem klinik görünüm hem de tedavi seçenekleri anlamında artmakta ve değerli çalışmalar yapılmaktadır. [88][89][90][91][92][93][94][95] Bununla birlikte özellikle duygudurum bozukluklarında biyolojik ritme işaret eden uyku bozukluklarının ve uykuuyanıklık döngüsü farklılıklarının yaygınlığı, psikiyatrik bozuklukların oluşumuna, seyrine ve tedavi seçeneklerine etkilerini biyolojik değişkenlerle birlikte araştıran çalışmaların yaygınlaşmasına ihtiyaç vardır. Kaynaklar…”

Effects of Chronotype and Social Jet-Lag on Neurocognitive Functioning

“…The chronotype, which reflects the daily activities of individuals and their circadian rhythm preferences in sleepwake cycles, can be discussed in one extreme morningness and one extreme eveningness dimension (Wittmann et al 2006, Roenneberg et al 2019. It is already known that individuals with extreme morningness and eveningness chronotypes are faced with many physical and mental dangers because of accumulated sleep debt, short total sleep time, and insufficient sleep efficiency (Selvi et al 2012). SJL, which occurs in extreme chronotypes, especially in extreme eveningness, because of the discord between social and circadian clocks, deteriorates these dangers even more (Ong et al 2021, Fárková et al 2021, Al-Khatib et al 2022.…”