Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study

Mani, Renuka; Vijayakumar, Natesan; Arumugam, R.

doi:10.1016/j.biopha.2016.05.013

Cited by 35 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, NH 4 Cl-induced hyperammonemic rats exhibited significantly increased expression and activity of the cerebral Na + /K + -ATPase. Previous studies have showed similar findings in hyperammonemic brain conditions [16, 25, 26]. The exact underlying mechanism of the activated Na + /K + -ATPase in hyperammonemia is not fully understood.…”

Section: Discussionmentioning

confidence: 60%

See 1 more Smart Citation

Commiphora molmol Modulates Glutamate‐Nitric Oxide‐cGMP and Nrf2/ARE/HO‐1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Mahmoud

Alqahtani

Othman

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutamate-NO-cGMP and Nrf2/ARE/HO-1 signaling pathways. Rats received NH4Cl and C. molmol for 8 weeks. NH4Cl-induced rats showed significant increase in blood ammonia, liver function markers, and tumor necrosis factor-alpha (TNF-α). Concurrent supplementation of C. molmol significantly decreased circulating ammonia, liver function markers, and TNF-α in hyperammonemic rats. C. molmol suppressed lipid peroxidation and nitric oxide and enhanced the antioxidant defenses in the liver, kidney, and cerebrum of hyperammonemic rats. C. molmol significantly upregulated Nrf2 and HO-1 and decreased glutamine and nitric oxide synthase, soluble guanylate cyclase, and Na+/K+-ATPase expression in the cerebrum of NH4Cl-induced hyperammonemic rats. Hyperammonemia was also associated with hematological and coagulation system alterations. These alterations were reversed by C. molmol. Our findings demonstrated that C. molmol attenuates ammonia-induced liver injury, oxidative stress, inflammation, and hematological alterations. This study points to the modulatory effect of C. molmol on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, C. molmol might be a promising protective agent against hyperammonemia.

show abstract

Section: Discussionmentioning

confidence: 60%

“…Excess ammonia also increases the activity of Na + /K + -ATPase in the brain [25]; however, the underlying mechanism remains unclear. Increased activity of the brain Na + /K + -ATPase in hyperammonemia has been demonstrated in multiple previous studies [16, 26]. …”

Section: Introductionmentioning

confidence: 77%

Commiphora molmol Modulates Glutamate‐Nitric Oxide‐cGMP and Nrf2/ARE/HO‐1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Mahmoud

Alqahtani

Othman

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Two flavonoids have been reported to decrease blood ammonia by increasing the expression of urea cycle enzymes [19][20][21][22][23] . However, whether this increased expression improves exercise endurance remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids such as nobiletin 19 , naringin 20 , chrysin 21 , and fisetin 22,23 have been shown to improve ammonia resistance and up-regulate urea cycle enzymes 19,20,22 ; however, whether this up-regulation is effective for lowering exercise-induced hyperammonaemia remains unknown. One group of flavonoids, the green tea catechins (GTCs), have been shown to have several health-promoting impacts, including anti-cancer effects, hepatoprotective effects, anti-diabetic effects, and anti-obesity effects 24 ; however, the impact of GTCs on ammonia metabolism remains to be examined.…”

mentioning

confidence: 99%

Involvement of ammonia metabolism in the improvement of endurance performance by tea catechins in mice

Chen

Minegishi

Hasumura

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Blood ammonia increases during exercise, and it has been suggested that this increase is both a central and peripheral fatigue factor. Although green tea catechins (Gtcs) are known to improve exercise endurance by enhancing lipid metabolism in skeletal muscle, little is known about the relationship between ammonia metabolism and the endurance-improving effect of GTCs. Here, we examined how ammonia affects endurance capacity and how GTCs affect ammonia metabolism in vivo in mice and how GTCs affect mouse skeletal muscle and liver in vitro. in mice, blood ammonia concentration was significantly negatively correlated with exercise endurance capacity, and hyperammonaemia was found to decrease whole-body fat expenditure and fatty acid oxidation-related gene expression in skeletal muscle. Repeated ingestion of Gtcs combined with regular exercise training improved endurance capacity and the expression of urea cycle-related genes in liver. In C2C12 myotubes, hyperammonaemia suppressed mitochondrial respiration; however, pre-incubation with Gtcs rescued this suppression. together, our results demonstrate that hyperammonaemia decreases both mitochondrial respiration in myotubes and whole-body aerobic metabolism. thus, Gtc-mediated increases in ammonia metabolism in liver and resistance to ammonia-induced suppression of mitochondrial respiration in skeletal muscle may underlie the endurance-improving effect of GTCs.Exercise-induced fatigue is an important concern in sports, exercise, and rehabilitation because it is unavoidable and its early onset can hinder people from accomplishing their goals. Exercise-induced fatigue is commonly assessed as endurance capacity, based on the assumption that time to exhaustion correlates with the force generating capacity of muscle, and it is attributed to multiple factors, including the accumulation of fatigue metabolites, depletion of muscle glycogen, decrease of muscle pH, increase of muscle temperature, and production of inflammatory cytokines 1,2 . The complexity of the mechanisms underlying the development of exercise-induced fatigue makes it difficult to find approaches to mitigate its effects.Ammonia is a ubiquitous waste product of the metabolism of nitrogenous compounds, including amino acids and proteins, and has long been considered both a central and peripheral factor in the onset of exercise-induced fatigue 3 . During exercise, ammonia is produced via deamination of adenosine monophosphate 4,5 and the breakdown of branched-chain amino acids in skeletal muscle 6,7 . The production of ammonia increases with increasing intensity and duration of exercise [8][9][10] . Although the ammonia fatigue theory is not new, there remains a lack of conclusive evidence proving the roles of ammonia in the onset and development of exercise-induced fatigue.Recent evidence from exercise and disease studies has provided new insights into the role of ammonia during exercise. For example, it has been reported that ammonia activates phosphofructokinase and inhibits the oxidation of pyruvate to acety...

show abstract

“…Chrysin (Figure 1E) is another flavone found in honey, propolis, and various plant extracts such as chamomile and blue passion flower ( Passiflora caerulea ; Renuka et al, 2016). Chrysin has multiple biological activities, including antitumor effects in diverse cancer cell lines and tumor animal models (Kasala et al, 2015).…”

Section: Flavonoidsmentioning

confidence: 99%

New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds

et al. 2017

View full text Add to dashboard Cite

Combination therapy consists in the simultaneous administration of a conventional chemotherapy drug (or sometimes, a radiotherapy protocol) together with one or more natural bioactives (usually from plant or fungal origin) of small molecular weight. This combination of anticancer drugs may be applied to cell cultures of tumor cells, or to an animal model for a cancer type (or its xenograft), or to a clinical trial in patients. In this review, we summarize current knowledge describing diverse synergistic effects on colorectal cancer cell cultures, animal models, and clinical trials of various natural bioactives (stilbenes, flavonoids, terpenes, curcumin, and other structural families), which may be important with respect to diminish final doses of the chemotherapy drug, although maintaining its biological effect. This is important as these approaches may help reduce side effects in patients under conventional chemotherapy. Also, these molecules may exerts their synergistic effects via different cell cycle pathways, including different ones to those responsible of resistance phenotypes: transcription factors, membrane receptors, adhesion and structural molecules, cell cycle regulatory components, and apoptosis pathways.

show abstract

Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study

Cited by 35 publications

References 40 publications

Commiphora molmol Modulates Glutamate‐Nitric Oxide‐cGMP and Nrf2/ARE/HO‐1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Commiphora molmol Modulates Glutamate‐Nitric Oxide‐cGMP and Nrf2/ARE/HO‐1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats

Involvement of ammonia metabolism in the improvement of endurance performance by tea catechins in mice

New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds

Contact Info

Product

Resources

About