Chrysin reduces inflammation and oxidative stress and improves ovarian function in D-gal-induced premature ovarian failure

Li, Xinning; Li, Xuelan; Deng, Ling

doi:10.1080/21655979.2021.2005991

Cited by 24 publications

(8 citation statements)

References 39 publications

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“…These natural products encompassed substances derived from plants to marine organisms. Among the phytochemicals, bioactive substances from plants were extensively investigated [ 27 , 30 , 32 – 37 , 39 – 43 , 46 , 47 , 49 – 52 , 63 ]. In addition, marine natural products such as tilapia skin peptides [ 38 ], oyster polypeptides [ 44 ], sea cucumber peptide [ 31 ], and coenzyme Q10 [ 45 ] were also explored.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Hu,

Zhang,

Xin

et al. 2024

J Ovarian Res

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Objective This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF). Methods We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative stress markers, inflammatory factors, and protein changes. The data was analyzed using random-effects meta-analyses, calculating pooled standardized mean differences and 95% confidence intervals. Heterogeneity was assessed using the I2 statistic, and bias was estimated using the SYRCLE tool. Results Among the 879 reviewed records, 25 articles met our inclusion criteria. These findings demonstrate that treatment with different phytochemicals and marine natural products (flavonoids, phenols, peptides, and alkaloids, etc.) significantly improved various aspects of ovarian function compared to control groups. The treatment led to an increase in follicle count at different stages, elevated levels of key hormones, and a decrease in atretic follicles and hormone levels associated with POF. This therapy also reduced oxidative stress (specifically polyphenols, resveratrol) and apoptotic cell death (particularly flavonoids, chrysin) in ovarian granulosa cells, although it showed no significant impact on inflammatory responses. The certainty of evidence supporting these findings ranged from low to moderate. Conclusions Phytochemicals and marine natural product therapy (explicitly flavonoids, phenols, peptides, and alkaloids) has shown potential in enhancing folliculogenesis and improving ovarian function in animal models of POF. These findings provide promising strategies to protect ovarian reserve and reproductive health. Targeting oxidative stress and apoptosis pathways may be the underlying mechanism.

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Section: Resultsmentioning

confidence: 99%

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Hu,

Zhang,

Xin

et al. 2024

J Ovarian Res

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“…Increasing evidence suggests that abnormal inflammatory states and oxidative stress in GCs are important causes of the decline in ovarian reserve 9 , 44 , 45 and many antioxidant drugs have been explored for their potential to protect against POF 13 , 46 . MET, as a multifunctional drug that has been extensively studied in recent years, has been shown to have anti-inflammatory, antioxidant, and anti-aging effects in various disease models 47 , 48 .…”

Section: Discussionmentioning

confidence: 99%

Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway

Yang,

Tang,

Yao

et al. 2024

Sci Rep

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Premature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment of POF damaged by chemotherapy drugs remains unclear. In this study, we investigated the impact of MET on POF caused by cyclophosphamide (CTX) combined with busulfan (BUS) and M1 macrophages using POF model mice and primary granule cells (GCs). Our findings demonstrate that intragastric administration of MET ameliorates ovarian damage and alleviates hormonal disruption in chemotherapy-induced POF mice. This effect is achieved through the reduction of inflammatory and oxidative stress-related harm. Additionally, MET significantly relieves abnormal inflammatory response, ROS accumulation, and senescence in primary GCs co-cultured with M1 macrophages. We also observed that this protective role of MET is closely associated with the AMPK/PPAR-γ/SIRT1 pathway in cell models. In conclusion, our results suggest that MET can protect against chemotherapy-induced ovarian injury by inducing the expression of the AMPK pathway while reducing oxidative damage and inflammation.

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“…Additionally, increased expression of SASP markers in the ovaries led to premature ovarian failure, suggesting that SASP may contribute to ovarian ageing [ 45 ]. Moreover, inhibiting GC proliferation may interfere with proper follicular development and resulted in a decline in ovarian function [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

miR-143-3p Promotes Ovarian Granulosa Cell Senescence and Inhibits Estradiol Synthesis by Targeting UBE2E3 and LHCGR

Deng

Tang

et al. 2023

IJMS

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The ovary is a highly susceptible organ to senescence, and granulosa cells (GCs) have a crucial role in oocyte development promotion and overall ovarian function maintenance. As age advances, GCs apoptosis and dysfunction escalate, leading to ovarian aging. However, the molecular mechanisms underpinning ovarian aging remain poorly understood. In this study, we observed a correlation between the age-related decline of fertility and elevated expression levels of miR-143-3p in female mice. Moreover, miR-143-3p was highly expressed in senescent ovarian GCs. The overexpression of miR-143-3p in GCs not only hindered their proliferation and induced senescence-associated secretory phenotype (SASP) but also impeded steroid hormone synthesis by targeting ubiquitin-conjugating enzyme E2 E3 (Ube2e3) and luteinizing hormone and human chorionic gonadotropin receptor (Lhcgr). These findings suggest that miR-143-3p plays a substantial role in senescence and steroid hormone synthesis in GCs, indicating its potential as a therapeutic target for interventions in the ovarian aging process.

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Chrysin reduces inflammation and oxidative stress and improves ovarian function in D-gal-induced premature ovarian failure

Cited by 24 publications

References 39 publications

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway

miR-143-3p Promotes Ovarian Granulosa Cell Senescence and Inhibits Estradiol Synthesis by Targeting UBE2E3 and LHCGR

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