Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure

Wronkiewicz, Stephanie K.; Roggli, Victor L.; Hinrichs, Benjamin H.; Kendler, Ady; Butler, Rondi A.; Christensen, Brock C.; Marsit, Carmen J.; Nelson, Heather H.; McClean, Michael D.; Kelsey, Karl T.; Langevin, Scott M.

doi:10.1038/s41379-019-0332-7

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…In our subgroup analysis of asbestos species, we found that exposure to chrysolite and mixed asbestos (containing chrysolite) was significantly associated with an increased SMR in esophageal cancer. A similar result was found in Wronkiewicz et al’s study, which showed tissue surrounding pharyngeal cancer and laryngeal cancer in 6 cases with a history of occupational asbestos exposure through scanning electron microscopy, and chrysolite fibers were noted in the tissues of 3 cases [ 58 ]. Our results did not show a significantly increased SMR in participants who were exposed to amosite and crocidolite.…”

Section: Discussionsupporting

confidence: 83%

Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

Chuang

Tsai

et al. 2021

IJERPH

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Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mortality rate (SMR) from the meta-analysis. Subgroup analysis according to the type of asbestos exposure, follow-up years, sample size, industry classification, sex, and high-dose exposure was conducted. Results: From 242 studies, 34 cohort studies were included in our meta-analysis. Pooled SMR was positively associated with asbestos exposure and esophageal cancer (pooled SMR = 1.28; 95% confidence interval (CI) 1.19–1.38, p < 0.00001). In the subgroup analysis, (1) chrysolite, (2) four groups with follow-up over ten years, (3) the textile industry and shipyard, (4) both male and female, and (5) eight studies on highest asbestos exposure, all the subgroups showed significantly increased pooled SMRs. Conclusion: Asbestos exposure was significantly and positively associated with esophageal cancer, especially chrysolite. Considering the long latency period, we suggest that patients should be followed up for cancer, including esophageal cancer, for over ten years.

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Section: Discussionsupporting

confidence: 83%

Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

Chuang

Tsai

et al. 2021

IJERPH

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“…The main risk factors for LC are tobacco and alcohol use, which would contribute to about 90% of the overall worldwide mortality for LC [16]. Exposure to textile dust [17], polyaromatic hydrocarbons, and asbestos [18], infection with human papillomavirus [19], and red meat consumption [20] also contribute to the elevated incidence of LC. Clearly, control of exposure to risk factors and adoption of healthy lifestyles, maintaining a healthy weight should be strengthened to reduce the global burden of this disease.…”

Section: Discussionmentioning

confidence: 99%

The global, regional, and national burden of laryngeal cancer and the attributable risk factors in all countries and territories during 2007–2017

Shen

Lin

et al. 2021

Front. Biosci. (Landmark Ed)

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Introduction 3. Materials and methods 3.1 Overview 3.2 Data sources 3.3 Disease burden estimation 3.4 Risk factors 3.5 Socio-demographic index (SDI) 4. Results 4.1 The number of incident cases and the age-standardized incidence rate per 100,000 population by countries and territories 4.2 The DALY counts and age-standardized DALY rate per 100,000 population by countries and territories 4.3 The death counts and age-standardized death rate per 100,000 population by countries and territories 4.4 The numbers of risk-attributable DALYs and deaths and the percentage changes in the risk-attributable age-standardized DALYs and death rates globally 5. Discussion 6. Conclusions 7. Author contributions 8. Ethics approval and consent to participate 9. Acknowledgment 10. Funding 11. Conflict of interest 12. References

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“…Firefighters are exposed to a wide variety of known carcinogenic chemicals and particulates,3 6 including asbestos, which has been associated with pharyngeal and laryngeal cancer22–24 29—including detection of chrysotile fibres adjacent to a laryngeal tumour in a case with an occupational history as a firefighter33—and PAH 21 22…”

Section: Discussionmentioning

confidence: 99%

Firefighter occupation is associated with increased risk for laryngeal and hypopharyngeal squamous cell carcinoma among men from the Greater Boston area

et al. 2020

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ObjectiveFirefighters are exposed to a wide variety of carcinogens during the line of duty, including several associated with head and neck cancer. Existing studies assessing head and neck cancer risk with firefighting have predominately included occupational cohorts or registry data, which are limited by inability to adjust for smoking and alcohol consumption—major risk factors for head and neck cancer. Our objective was to assess the risk of head and neck cancer among men with an occupational history as a firefighter.MethodsThis work was conducted using male subjects from a large population-based case–control study of head and neck cancer from the greater Boston area using self-reported occupational history (718 cases and 905 controls).ResultsAn occupational history as a firefighter was reported for 11 cases and 14 controls. Although no significant association was observed overall, we observed substantial increased risk for hypopharyngeal and laryngeal squamous cell carcinoma among professional municipal firefighters who had a light or no smoking history (OR=8.06, 95% CI 1.74 to 37.41), with significantly increasing risk per decade as a firefighter (OR=2.10, 95% CI 1.06 to 4.14).ConclusionProfessional municipal firefighters may be at increased risk for hypopharyngeal and laryngeal squamous cell carcinoma due to carcinogenic exposures encountered during the line of duty.

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Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure

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Cited by 8 publications

References 27 publications

Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

The global, regional, and national burden of laryngeal cancer and the attributable risk factors in all countries and territories during 2007–2017

Firefighter occupation is associated with increased risk for laryngeal and hypopharyngeal squamous cell carcinoma among men from the Greater Boston area

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