Chuanxiong chadiao powder, a famous Chinese herbal prescription, for headache: A systematic review and meta-analysis

Li, Ji-huang; Cao, Xiaopan; Wei, Jingjing; Song, Lina; Liao, Feng-jiao; 鄭, 国慶

doi:10.1016/j.ctim.2015.06.012

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…A former review (Zhou et al, 2013 ) published in 2013 found some evidence of supporting the use of TCM for migraine; however the poor methodological quality and significant publication bias prevented the author making firm conclusions. Our previous review (Li et al, 2015 ) in 2015 also demonstrated that Chuanxiong Chadiao powder may be effective and safe for the treatment of headache. This is a systematic review of 19 high-quality RCTs with 1832 participants to determine the efficacy and safety of Chuanxiong formulae for migraine.…”

Section: Discussionmentioning

confidence: 95%

“…(Chuanxiong) originated from Divine Husbandman's Classic of the Materia Medica ( Shen Nong Ben Cao Jing ), is a well-known TCM herb (China Pharmacopoeia Committee, 2005 ). Based on the literature review, Chuanxiong formulae are the most common used Chinese classical and/or patent prescription for treating headache both in ancient and modern time (Zheng Q. et al, 2013 ; Li et al, 2015 ). In spite of thousands of years' application history, the efficacy and safety evaluation of Chuanxiong formulae also should be scientifically performed.…”

Section: Introductionmentioning

confidence: 99%

“…In spite of thousands of years' application history, the efficacy and safety evaluation of Chuanxiong formulae also should be scientifically performed. Previous systematic reviews (Zhou et al, 2013 ; Li et al, 2015 ) of TCM for migraine prevented to make firm conclusions because of poor methodological quality of the primary studies. Therefore, the aim of this study is to assess the available evidence of Chuanxiong formulae for migraine according to high-quality randomized controlled trials (RCTs).…”

Section: Introductionmentioning

confidence: 99%

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Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Shan

Shi

et al. 2018

Front. Pharmacol.

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Objective: Migraine is a complex, prevalent and disabling neurological disorder characterized by recurrent episodes of headache without ideal treatment. We aim to assess the current available evidence of herbal Chuanxiong (Ligusticum chuanxiong Hort. root) formulae for the treatment of migraine according to the high-quality randomized controlled trials (RCTs).Methods: English and Chinese electronic databases were searched from their inceptions until March 2017. The methodological quality of included study was assessed by the Cochrane Collaboration risk of bias tool. RCTs with Cochrane risk of bias (RoB) score ≥4 were included in the analyses. Meta-analysis was conducted using RevMan 5.3 software. Publication bias was assessed by funnel plot analysis and Egger's test.Results: Nineteen RCTs with 1832 participants were identified. The studies investigated the Chuanxiong formulae vs. placebo (n = 5), Chuanxiong formulae vs. conventional pharmacotherapy (CP) (n = 13 with 15 comparisons), and Chuanxiong formulae plus CP vs. CP (n = 1). Meta-analysis indicated that Chuanxiong formulae could reduce frequency, duration, days and pain severity of migraine and improve the total clinical efficacy rate (P < 0.05). Adverse event monitoring was reported in 16 out of 19 studies and occurrence rate of adverse event was low.Conclusion: The findings of present study indicated that Chuanxiong formulae exerted the symptom reliefs of for migraine.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Shan

Shi

et al. 2018

Front. Pharmacol.

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“…However, methodological quality should be improved for further data analysis (J.‐h. Li et al, 2015). A multicenter, double‐dummy, controlled trial, including 360 adults, was designed to compare the effects of Zhengtian Capsule comprised of 15 herbal compositions such as Chuanxiong Rhizoma, Aconitum Sinomontanum, and Angelicae Dahuricae Radix, with flunarizine in the prophylaxis of migraine.…”

Section: Clinical Trialsmentioning

confidence: 99%

Role of herbal medicine for prevention and treatment of migraine

Chen

Wang

2021

Phytotherapy Research

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Migraine is a disabling neurovascular disease with unilateral or bilateral pulsatile headache, which intensively affects human health and quality of life due to high morbidity worldwide. Migraine is commonly accompanied by abnormal pain sensitization, neuroinflammatory response, and vasomotor dysfunction. Owing to the management dilemmas of migraine, there is an urgent need to develop effective and low-cost therapies. In recent years, herbal medicines as a promising strategy with analgesic activity and minor side effect, have been proposed for the prevention and treatment of migraine. Considering the lack of a review integrating experimental studies regarding the herbal treatment of migraine, this review systematically summarizes the important potential applications of herbal medicines in ameliorating migraine via multiple therapeutic targets and pathways, as well as provides a reference for further development of novel antimigraine drugs.

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“…Chinese herbal medicine (CHM), which is often prescribed to migraine patients in China [25], has gained clinical research evidence as an effective alternative or complementary therapy for migraine in recent years. However, most of the existing evidence has been generated from randomised controlled trials (RCTs) [26][27][28][29][30] and RCT-based systematic reviews [31][32][33][34]. Under controlled settings, RCTs usually apply strict selection criteria and provide unified treatments to all participants [35].…”

Section: Introductionmentioning

confidence: 99%

Migraine patients visiting Chinese medicine hospital: Protocol for a prospective, registry-based, real-world observational cohort study

Lyu

Zhang

et al. 2022

PLoS ONE

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Introduction Migraine is a disabling, recurrent headache disorder with complex comorbidities. Conventional treatments for migraine are unsatisfactory, with side effects and limited effectiveness. Chinese herbal medicine (CHM) has been used as an alternative or complementary treatment option for migraine in China. Currently, the existing evidence of benefit of CHM for migraine has been generated from randomised clinical trials using standardised intervention with a focus on internal validity hence with limited external validity. Moreover, CHM individualised intervention design, patients’ preferences and concerns, and clinicians’ experience are critical to clinical decision making and therapeutic success. This real-world observational study aims to gather practice-based evidence of effects and safety of CHM for migraine in the context of integrating Chinese medicine diagnostic procedures, patients’ preferences and matters relevant to clinical decision making. Methods and analysis The study is being undertaken at the Guangdong Provincial Hospital of Chinese Medicine (GPHCM) from December 2020 to May 2022. We anticipate that approximately 400 adult migraineurs will be enrolled and observed on their migraine severity, analgesic consumption, quality of life, anxiety, depression and insomnia at baseline and then every four weeks over 12 weeks. Treatments, diagnostic information, and patient-reported most bothersome symptoms will be collected from patient clinical records. Patient’s demographic data, preferences and concerns on CHM treatments will also be gathered at baseline and be analysed. Factors related to clinical outcomes will be explored with multiple correlation and multivariable regression analyses. Effects of CHM will be evaluated using generalised estimated equation, based on clinical outcome data. Discussion This study will provide comprehensive evidence of CHM for migraine in the context of evidence-based practice. Trial registration number ChiCTR2000041003

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Chuanxiong chadiao powder, a famous Chinese herbal prescription, for headache: A systematic review and meta-analysis

Cited by 14 publications

References 30 publications

Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Role of herbal medicine for prevention and treatment of migraine

Migraine patients visiting Chinese medicine hospital: Protocol for a prospective, registry-based, real-world observational cohort study

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