Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model

Kim, Hyeong-Geug; Kim, Jungmin; Han, Jong-Min; Lee, Jin-Seok; Choi, Min‐Kyung; Lee, Dong‐Soo; Park, Yeon-Hwa; Son, Chang‐Gue

doi:10.3748/wjg.v20.i42.15703

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…miltiorrhiza . We previously compared the antihepatofibrotic activities of thirteen herbs of CGX with respect to TGF- β inhibition using the HSC T-6 cell line [ 45 , 46 ]. From those experimental data and practical theory of the traditional Korean pharmacology, we finally selected the abovementioned three herbal plants.…”

Section: Discussionmentioning

confidence: 99%

A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine‐Induced SD Rat Model

Kim

Lee

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A. iwayomogi, A. xanthioides, and S. miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis. Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly). Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily. DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII. CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents. Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII. Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII. The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection. Administration of CGXII normalized the protein and gene expression levels of these cytokines. Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects.

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Section: Discussionmentioning

confidence: 99%

A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine‐Induced SD Rat Model

Kim

Lee

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…It comprises herbal drugs which originated from TKM prescription. It has been proven to improve various chronic liver disease such as cholestatic liver fibrosis, liver chrrhosis, alcoholic liver disease, and chronic viral hepatitis in many patients or rat model [24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

Acute Viral Hepatitis A with Cholestatic Hepatitis Treated with Traditional Korean Medicine: A Case Report

et al. 2015

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More and more patients suffering from hepatitis A, the number of patients representing symptoms that are uncharacteristic to hepatitis A is also increasing. There are occasions of serious complications among adult hepatitis A patients that can cause fulminant hepatitis or cirrhosis which can be fatal. A 43-year-old male was diagnosed as acute hepatitis A and was treated at a Western hospital over the course of three months, which included two months of hospitalization. However, his symptoms did not improve, so he was admitted to Oriental hospital. We prescribed Chunggan extract (CGX) four times a day. Acupuncture was performed twice a day. From the twenty-fourth day of admission, the total bilirubin fell under 10 mg/dL for the first time and next day he was discharged. Following his discharge, he consistently took CGX three times a day. 21 days after discharge all of his symptoms disappeared. This study demonstrated that traditional Korean medicine (TKM) for acute viral hepatitis with cholestatic hepatitis might be effective and safe with no adverse effects.

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“…Chunggan extract (CGX) is a commercially marketed herbal medicine of 13 herbs, which finds its utility as a potent "liver cleaning" agent (Choi et al, 2006;Kim et al, 2014). Kim et al (2014) observed pharmacological properties of CGX with the main focus on molecules related to alcohol metabolism and profibrogenic cytokines. They also saw the mechanism in ratderived HSC cell line (using HSC-T6 cells) (Kim et al, 2014).…”

Section: Ethnopharmacological Applications Targeting Alcohol Abusementioning

confidence: 99%

“…Kim et al (2014) observed pharmacological properties of CGX with the main focus on molecules related to alcohol metabolism and profibrogenic cytokines. They also saw the mechanism in ratderived HSC cell line (using HSC-T6 cells) (Kim et al, 2014).…”

Section: Ethnopharmacological Applications Targeting Alcohol Abusementioning

confidence: 99%

“…Under this circumstances, natural products are attractive option for treatment of alcoholinduced liver impairment (Ao et al, 2009). At present there is no therapeutic cure for alcoholic liver disease (ALD); hence, the development of novel medicines that are effective against alcoholic injury is the need of the hour (Kim et al, 2014). The modern pharmacological approaches are believed to play a vital role in achieving complete alcohol self-restraint and prevent relapse, but have limited efficacy with high adverse effects (Addolorato et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

et al. 2020

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Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self-restraint and prevent relapse, but they have many side effects. Natural products are most promising as they cause fewer adverse effects. Here we discuss in detail the medicinal plants used in various traditional/folklore medicine systems for targeting alcohol abuse. We also comprehensively describe preclinical and clinical studies done on some of these plants along with the possible mechanisms of action.

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Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model

Abstract: The present study evidenced that CGX has hepatoprotective properties via modulation of fibrogenic cytokines and alcohol metabolism in alcoholic liver injury.

Cited by 14 publications

References 46 publications

A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine‐Induced SD Rat Model

A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine‐Induced SD Rat Model

Acute Viral Hepatitis A with Cholestatic Hepatitis Treated with Traditional Korean Medicine: A Case Report

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

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