Churg-Strauss syndrome

Lymph node involvement by Langerhans cell histiocytosis: a clinicopathologic and immunohistochemical study of 20 cases

“…In this setting, the classic histology of HL with presence of Reed-Sternberg cells and the identification of CD15/CD30-positive cells by immunohistochemistry will lead to a correct interpretation. Allergic granulomatosis (Churg-Strauss syndrome) is usually a systemic disease characterized by asthma, hypereosinophilia, systemic vasculitis, and transient pulmonary infiltrates, which has also been reported in a more limited and indolent form in the eyes, skin, and gastrointestinal tract [26][27][28][29]. A case describing allergic granulomatosis limited to lymph node has been presented in the literature [29].…”

Pulmonary infarction and deep venous thrombosis in a 13‐year‐old boy with Churg–Strauss syndrome

“…Churg–Strauss syndrome (CSS) is one of these and is characterized by hypereosinophilia and systemic vasculitis that develops in patients with allergic disorders 1 . Some patients with CSS have multisystemic involvement and often have various complications 2,3 . The purpose of this report is to describe a case of CSS associated with pulmonary infarction and deep venous thrombosis and to summarize the patients in childhood previously reported.…”

Collagenolytic (necrobiotic) granulomas: part II – the ‘red’ granulomas

“…Slightly more common in males, CSS typically strikes patients in their late 20s through late 30s, 61 but cases of patients as young as 12 years of age have been reported 62 . The American College of Rheumatology requires that a minimum of four of the following criteria be met to make the diagnosis: (1) asthma, (2) eosinophilia greater than 10% on a differential (this value exceeds the level which is present in patients with extrinsic asthma, which seldom exceeds 0.8 × 10 9 /l), 61 (3) mononeuropathy or polyneuropathy, (4) fixed pulmonary infiltrate on radiologic exam, (5) paranasal sinus abnormalities, and/or (6) a biopsy that contains a blood vessel with extravascular eosinophils 63 . Because asthma is not necessarily a part of the syndrome, reports exist of patients dying of the cardiac complications of undiagnosed and therefore untreated CSS 64 .…”

“…Because asthma is not necessarily a part of the syndrome, reports exist of patients dying of the cardiac complications of undiagnosed and therefore untreated CSS 64 . Cutaneous involvement occurs in two‐thirds of CSS cases 63 …”

“…The typical radiographic findings include transient patchy infiltrates, bilateral nodular infiltrates, or an interstitial pattern. Pulmonary effusions occur in about one‐third of cases and typically contain large amounts of eosinophils 63 …”