Chylomicron remnants regulate early growth response factor-1 in vascular smooth muscle cells

Takahashi, Yuko; Fujioka, Yoshio; Takahashi, Toshifumi; Domoto, Koji; Takahashi, Akihiro; Taniguchi, Takahiro; Ishikawa, Yuichi; Yokoyama, Mitsuhiro

doi:10.1016/j.lfs.2005.01.012

Cited by 23 publications

(11 citation statements)

References 46 publications

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“…We have demonstrated that rat chylomicron remnants strongly stimulated mRNA expression and protein secretion of MCP-1 in vascular smooth muscle cells (SMC) by activation of p38 mitogen-activated protein kinase (MAPK) 46) . We have also demonstrated that chylomicron remnants induced early growth response factor-1 (Egr-1) mRNA and protein expression in vascular SMC 47) . Egr-1, the zinc-finger transcription factor, is induced by various stimuli, including growth factors, cytokines, hypoxia, and sheer stress, and induced genes have been implicated in the pathogenesis of atherosclerosis 48) .…”

Section: Inflammationmentioning

confidence: 88%

Remnant Lipoproteins As Strong Key Particles to Atherogenesis

Fujioka

Ishikawa

2009

J Atheroscler Thromb

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121

115

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Recent epidemiologic studies have revealed that hypertriglyceridemia is associated with atherosclerosis independent of other coronary risk factors. However, it is difficult to select patients at high risk for coronary artery disease using only serum triglyceride levels compared with low-density lipoprotein cholesterol levels since multiple factors are associated with elevating triglycerides. Atherosclerotic diseases with high triglyceride levels can be found in patients with familial combined hyperlipidemia, diabetes mellitus, and metabolic syndrome, in which remnant lipoproteins accumulate in the circulating blood. Recent researches have paid attention to remnant lipoproteins as atherogenic particles with the development of methods for measuring remnant cholesterol levels and apolipoprotein B-48 levels directly from human serum. Measurement of these parameters in addition to serum triglycerides may help to distinguish high-risk patients and enable us to prevent or suppress the progression of atherosclerotic diseases in those patients. However, questions remain to be answerd to evaluate the significance of remnant lipoproteins. Here, we focus on three issues: the underlying problems in measuring remnant lipoprotein cholesterol, the assessment of postprandial hyperlipidemia as an atherogenic condition, and finally a review of our experimental and clinical findings about the mechanisms by which remnant lipoproteins induce atherosclerosis.

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Section: Inflammationmentioning

confidence: 88%

Remnant Lipoproteins As Strong Key Particles to Atherogenesis

Fujioka

Ishikawa

2009

J Atheroscler Thromb

Self Cite

121

115

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“…Importantly, the chylomicron remnants used in this study were prepared freshly for each experiment, so they did not undergo oxidative modification such as the formation of OxLDL. On the other hand, chylomicron remnants contain LPC as a result of hydrolysis (7)(8)(9)25). Thus, LPC may have contributed to the stimulation of IL-1β production by chylomicron remnants, as opposed to the case of OxLDL.…”

Section: Discussionmentioning

confidence: 99%

“…The biologic mechanisms by which lipids induce the vascular inflammation, cellular proliferation, lipid deposition, and fibrosis that characterize atherosclerosis remain largely unknown, but recent findings suggest that oxidative modification of low-density lipoproteins (LDL) is a key contributor to the progression of atherosclerosis (1,2). On the other hand, triglyceride-rich lipoprotein particles including chylomicron remnants are also atherogenic (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Chylomicron remnants are derived from chylomicrons through lipoprotein lipase-mediated hydrolysis of triglycerides in these particles.…”

Section: Introductionmentioning

confidence: 99%

Chylomicron Remnants Stimulate Release of Interleukin-1.BETA. by THP-1 Cells

Okumura¹,

Fujioka²,

Morimoto³

et al. 2006

JAT

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“…The C2H2 (also known as TFIIIA/Kruppel) zinc finger motif, in which the zinc-binding motif is determined by the presence of two cysteine and two histidine residues that engage in a four-coordinate bond with a single zinc ion, is the most abundant DNA-binding motif among putative eukaryotic transcriptional factors [59]. Several zinc finger proteins have been reported, e.g., the Krueppel-like factors, and the early growth response factor [60][61][62]. The zinc finger protein 670 has rarely been reported in the past.…”

Section: Discussionmentioning

confidence: 99%