Chylothorax in a case of accelerated silicosis with pulmonary silicoproteinosis: A unique association

Sasi, Archana; Goel, Ayush; Bhalla, Ashu Seith; Arava, Sudheer; Agarwal, Shubham; Jadon, Ranveer Singh; Vikram, Naval Kishore

doi:10.4103/ijoem.ijoem_63_19

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…In animal models, both accelerated silicosis with high-dose silica and chronic silicosis with low-dose silica exposures induce granulomatous changes in the lung [ 30 , 31 ]. The granuloma-like structures in accelerated silicosis are loosely aggregated foamy histiocytes [ 32 ]. In present study, we examined the dynamic change from inflammation to fibrosis in acute silicosis.…”

Section: Resultsmentioning

confidence: 99%

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Sai

et al. 2021

Genes and Environ

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Background Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of silicosis in rats exposed to RCS with focus on the regulation of long noncoding RNAs (lncRNAs). Results The results showed that RCS induced acute inflammatory response as indicated by the appearance of inflammatory cells in the lung from the first day and peaked on day 7 of exposure. The fibroblasts appeared along with the inflammatory cells decreasing gradually on day 14. Extensive fibrosis appeared in the lung tissue, and silicon nodules were getting larger on day 28. Interestingly, the number of altered lncRNAs increased with the exposure time with 193, 424, 455, 421 and 682 lncRNAs on day 1, 7, 14, 21, and 28 after exposure, respectively. We obtained 285 lncRNAs with five significant temporal expression patterns whose expressions might correlate with severity of silicosis. KEGG analysis showed that lncRNAs from short time-series expression miner (STEM)-derived data mainly involved in 17 pathways such as complement and coagulation cascades. Conclusions The differential expression profiles of lncRNAs may be potential biomarkers in silicosis through modulating expressions of their relevant genes in lungs of rat and thus warrant further investigation.

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Section: Resultsmentioning

confidence: 99%

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Sai

et al. 2021

Genes and Environ

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“…Complications of silicosis include pneumothorax, pneumomediastinum, and rarely chylothorax [7,[10][11][12][13][14]. More importantly, silica accumulation in lung macrophages causes dysfunctional phagocytosis, which increases susceptibility to infections, especially with Mycobacterium tuberculosis.…”

Section: Key Pointsmentioning

confidence: 99%

Silica-associated lung disease in developing countries

Dhooria

Sehgal

Agarwal

2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewThere is a considerable burden of silica-associated lung diseases in the developing world. This review summarizes the epidemiology of these diseases, especially silicosis and silico-tuberculosis, mitigative efforts and treatment, especially in the context of developing countries.Recent findingsIn 2017, the highest incidence of silicosis was in China, India and Brazil among the developing countries. The prevalence of silicosis amongst exposed workers may vary from 4 to 55%; there is a risk of underestimation because of the ‘healthy worker effect’. The permissible exposure limit for respirable silica adopted by governments in developing countries remains higher than the proposed 0.025 mg/m3. Silica exposure in informal or unorganized industries is challenging, as it falls outside statutory controls. Recent efforts on regulation and compensation by various governments in developing countries are encouraging but need proper implementation on the ground. Biomarkers such as club cell protein 16 and imaging methods such as computed tomography may offer earlier and easier detection of silicosis. Advanced silicosis remains incurable; novel treatments such as antifibrotics agents may be potentially effective.SummarySilica-associated lung diseases are prevalent in developing countries. Efforts directed at preventing or minimizing exposure to respirable crystalline silica are required for mitigation.

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“…A lung biopsy is not recommended to confirm the diagnosis of silicosis but could be performed to exclude other pathologies in the case of clear doubt [ 19 ]. Bronchoscopy and bronchoalveolar lavage could be useful in the diagnosis of silicoproteinosis [ 20 ] and silico-tuberculosis [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Workers with Suspected Diagnosis of Silicosis: A Case Study of Sarcoidosis Versus Siderosis

Delgado-García,

Miranda-Astorga,

Delgado-Cano

et al. 2023

Healthcare

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Silicosis is one of the most important occupational respiratory diseases worldwide, hence the importance of making a correct diagnosis. Diagnosis is commonly based on radiological findings according to the ILO International Classification of Radiographs of Pneumoconioses and occupational exposure. High-resolution computed tomography is indicated for differential diagnosis. This article presents two cases with an initial diagnosis of silicosis that ended up being diagnosed as sarcoidosis and siderosis, respectively. The first case was a 42-year-old male who worked as a crushing operator in an underground copper and molybdenum mine for 22 years. He had a history of exposure to silicon dioxide and was asymptomatic. X-rays did not distinguish silicosis or siderosis, but histological findings (open lung biopsy) allowed for a diagnosis of sarcoidosis. The second case was a 50-year-old male who had worked as a welder in a molybdenum filter plant, an open pit mine since 2013; he spent the previous 20 years as a welder in an underground copper mine, with exposure to silicon dioxide and was symptomatic. The first radiograph showed opacities that were compatible with pulmonary silicosis. A subsequent high-resolution computed tomography and lung biopsy showed a pattern of pulmonary siderosis. Due to the similarities in the radiographs of these three diseases, greater emphasis must be placed on the differential diagnosis, for which a complete occupational and clinical history is important in order to provide clues for the performance of complementary tests to avoid misdiagnosing.

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Chylothorax in a case of accelerated silicosis with pulmonary silicoproteinosis: A unique association

Cited by 3 publications

References 5 publications

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats

Silica-associated lung disease in developing countries

Workers with Suspected Diagnosis of Silicosis: A Case Study of Sarcoidosis Versus Siderosis

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