Chylothorax

Sedrak, Michael P.

doi:10.1007/978-3-319-66796-6_350

Cited by 1 publication

(1 citation statement)

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“…This crystallization produces a polymer nucleus, which grows and fills the RBC, disrupting its architecture and flexibility and promoting cellular dehydration, with physical and oxidative cellular stress. 1,2 SCD is endemic in 71% of all countries worldwide and it is estimated to affect at least 5.2% of the world ' s population.300000 infants are born with major haemoglobin disorders including SCD globally.…”

Section: Introductionmentioning

confidence: 99%

Potential of point of care tests for newborn screening for sickle cell disease: Evaluation of HemotypeSC™ and sickle SCAN® in Tanzania

Christopher

Josephat

Kaywanga

et al. 2022

Int J Lab Hematology

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Background: Sickle cell disease (SCD) is an important cause of <5 mortality. In Tanzania, it is estimated up to 11 000 children are born with SCD annually, making this the fifth country with the highest SCD annual births worldwide. The biggest challenge of expanding the service of newborn screening for SCD as the national health intervention in Tanzania is due to the high cost of the currently used assays and lack of rapid screening methods. Therefore, in this study, we assessed the diagnostic accuracy of point-of-care tests for SCD diagnosis in newborns.Aim: To evaluate the sensitivity and specificity of HemotypeSC™ and sickle SCAN ® in diagnosing SCD in newborns.Methods: Diagnostic accuracy of HemotypeSC™ and sickle SCAN ® were evaluated in comparison to isoelectric focusing as a confirmatory method.Results: A total of 706 newborns were enrolled in the study. The sensitivity and specificity of HemotypeSC in detecting Hb SS, Hb AS and Hb AA phonotypes was 100%. The sensitivity and specificity of sickle SCAN ® in detecting Hb SS, Hb AS and Hb AA phenotypes were 100%, 97% and 100% respectively. Conclusion:Both POC tests displayed high accuracy in detecting SCD, we believe the introduction of either of these tests in health facilities will help in the early detection and management of SCD. In addition, the margin of cost per test is relatively affordable (1.

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Section: Introductionmentioning

confidence: 99%