Cicada and catkin inspired dual biomimetic antibacterial structure for the surface modification of implant material

Ye, Jing; Deng, Jianjian; Chen, Yutong; Yang, Ting; Zhu, Yanglong; Wu, Chongxue; Wu, Tianlong; Jia, Jingyu; Wang, Xiaolei

doi:10.1039/c9bm00082h

Cited by 39 publications

(35 citation statements)

References 24 publications

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“…In our previous studies, we demonstrated that Si periodic pillar arrays with sub-micron motif sizes could significantly inhibit bacterial adhesion, proliferation, and colonization by a spatial confinement size-effect [34,35]. Our findings suggested that nano-pillar array might be the optimal topography design against bacteria, which was coincident with the design of nature for the bactericidal topographies on the surface of cicada wing [[36], [37], [38], [39], [40], [41]], dragonfly wing [38,41,42], and gecko skin [43]. The findings [34] were reported even before the first announcement of the natural bactericidal topography on the surface of cicada wing [36].…”

Section: Introductionmentioning

confidence: 63%

“…However, the clinical application of biomimetic nano-pillar array is not satisfactory [41], mainly because its antibacterial ability against Gram-positive strain including Staphylococcus aureus ( S. aureus ) is not good enough [37]. Since S. aureus usually causes implant-associated infections [3,44], the biomimetic nano-pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.…”

Section: Introductionmentioning

confidence: 99%

“…Since S. aureus usually causes implant-associated infections [3,44], the biomimetic nano-pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application. Recently, Ye et al [41] combined a nano-pillar array and ZnO nanoslices to prepare a cicada & catkin inspired structure that was demonstrated to simultaneously have ideal biocompatibility, better bacterial anti-adhesive property, broader antibacterial range, and long-lasting antibacterial activity. ZnO-based nanomaterials possess high antibacterial activity against both Gram-positive and -negative bacterial strains [[45], [46], [47], [48]], which has been mainly attributed to Zn 2+ ions release, bacterial cell membrane damage, and photocatalytic generation of reactive oxygen species (ROS) [49,50].…”

Section: Introductionmentioning

confidence: 99%

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Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications

Ren

Ding

et al. 2019

Bioactive Materials

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Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics. Given the global threat and increasing influence of antibiotic resistance, there is an urgent demand to explore novel antibacterial strategies other than using antibiotics. Recently, using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention. However, the clinical application of biomimetic nano-pillar array is not satisfactory, mainly because its antibacterial ability against Gram-positive strain is not good enough. Thus, the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application. Here, we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2. Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections. First, to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array, we systematically investigated its effects on bacterial adhesion, growth, proliferation, and viability in the dark without involving the photocatalysis of TiO2. The pillar array with sub-micron motif size can significantly inhibit the adhesion, growth, and proliferation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array. Moreover, the pillar array is not lethal to S. aureus and E. coli in 24 h. Then, the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work. This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications

Ren

Ding

et al. 2019

Bioactive Materials

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Section: Synergetic Antibacterial Strategymentioning

confidence: 99%

“…Ye et al [113] fabricated a cicada and catkin inspired dual biomimetic structure which could simultaneously possess higher bacterial anti‐adhesive ability, wider antibacterial range, and longer antibacterial durability. First, the burst release of ZnO nanoslices on the sample surface can kill the pathogenic bacteria chemically [113]. Then, the dual biomimetic structure will be exposed gradually and begin to exert its physical antibacterial property generated by the special nanoscale topography [113].…”

Section: Synergetic Antibacterial Strategymentioning

confidence: 99%

Antimicrobial biomaterials with non‐antibiotic strategy

2019

Biosurface and Biotribology

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Biomedical implants have revolutionised medicine, while they also increase the risk of implant-associated infection which is one of the most frequent and severe complications accompanied by the application of biomaterials. Since the widespread usage of antibiotics drives the emergence of multidrug-resistant strains, the orthopaedic implant infections are usually hard to treat due to the antibiotic resistance, tolerance and/or persistence of pathogens. Given the growing impact of multidrug resistance, an urgent need has been triggered to develop new types of antimicrobial strategy other than using antibiotics. In this review, the authors highlight the recent progress on antimicrobial biomaterials with non-antibiotic strategies including chemical strategy, physical strategy, and synergetic strategy. The antimicrobial mechanisms of many kinds of non-antibiotic antimicrobial biomaterials are still not fully understood. Researchers gradually found that welcoming microbial cellular adhesion to a lethal surface was a more effective solution than targeting microbial cellular repulsion when designing antimicrobial surfaces. Moreover, there is a popular tendency to make the antimicrobial biomaterials not only kill pathogenic microbes but also facilitate the adhesion and growth of the healthy cell, which means that the next generation biomaterials should possess dual functions of preventing microbial infection together with promoting tissue regeneration simultaneously for biomedical applications.

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Production of Antibacterial Activity and Bone Cell Proliferation by Surface Engineering of Ga‐ or Mn‐Doped Ceria‐Coated Biomedical Titanium Alloy

et al. 2022

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The present work reports a detailed interpretation of the role of Ga and Mn dopants, solid solubility mechanisms, charge compensation mechanisms, intervalence charge transfer, antibacterial performance, and cell attachment and proliferation. Sol–gel undoped and doped (1, 5, and 9 mol%) CeO2 films are spin‐coated on 3D printed Ti6Al4V biomedical alloy substrates and annealed at 650 °C for 2 h in air. Material characterization includes scanning electron microscopy (SEM), 3D scanning laser confocal microscopy, glancing angle X‐ray diffraction (GAXRD), and X‐ray photoelectron spectroscopy (XPS). In vitro testing includes inhibition of bacterial growth, simulated body fluid (SBF) testing, and cell attachment and proliferation studies. The most significant outcome is that the bioactivity of ceria derives directly from the Ce3+ concentration, which itself results from solid solubility (substitutional and interstitial) and charge compensation and redox. This challenges the common assumption of the dominance of oxygen vacancies in the performance of ceria. The antibacterial activity is dependent on the type, amount, and valence of the dopant, where opposite trends are observed for gram‐positive Staphylococcus aureus and gram‐negative Escherichia coli bacteria. All of the doped samples result in enhanced cell proliferation, although this is greatest at the lowest dopant concentration. Surface hydroxyapatite formation on the samples is achieved by soaking in SBF at 2 weeks and 1 month.

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Cicada and catkin inspired dual biomimetic antibacterial structure for the surface modification of implant material

Abstract: Inspired by cicadas and catkins, a delicate dual biomimetic antibacterial concept was proposed to modify implant material.

Cited by 39 publications

References 24 publications

Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications

Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications

Antimicrobial biomaterials with non‐antibiotic strategy

Production of Antibacterial Activity and Bone Cell Proliferation by Surface Engineering of Ga‐ or Mn‐Doped Ceria‐Coated Biomedical Titanium Alloy

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