Cicaderma® in radiation–related dermatitis of breast cancer: Results from the multicentric randomised phase III CICA-RT

Racadot, S.; Arnaud, Antoine; Schiffler, Camille; Metzger, Séverine; Pérol, David; Kirova, Youlia

doi:10.1016/j.ctro.2023.100647

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Although deaths by suicide associated with overdiagnosis were considered in the study, less extreme cases, such as depression, anxiety and posttraumatic stress disorder, are more prevalent and may be persistent [ 64 ]. Non-lethal adverse effects of overtreatment were also not considered in the present study, such as radiotherapy-induced acute dermatitis, which is common but generally of moderate intensity [ 65 , 66 ]. It is also necessary to consider that the increased risk of cardiovascular diseases after overtreatment with radiotherapy, for example, was only evaluated in terms of mortality, but certainly its increased incidence also has repercussions in terms of quality of life.…”

Section: Discussionmentioning

confidence: 99%

Harms and benefits of mammographic screening for breast cancer in Brazil

Migowski,

Nadanovsky,

Manso de Mello Vianna

2024

PLoS ONE

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Introduction In the absence of evidence on the effect of mammographic screening on overall mortality, comparing the number of deaths avoided with the number of deaths caused by screening would be ideal, but the only existing models of this type adopt a very narrow definition of harms. The objective of the present study was to estimate the number of deaths prevented and induced by various mammography screening protocols in Brazil. Methods A simulation study of cohorts of Brazilian women screened, considering various age groups and screening interval protocols, was performed based on life tables. The number of deaths avoided and caused by screening was estimated, as was the absolute risk reduction, the number needed to invite for screening—NNS, the net benefit of screening, and the ratio of “lives saved” to “lives lost”. Nine possible combinations of balances between benefits and harms were performed for each protocol, in addition to other sensitivity analyses. Results and conclusions The most efficient protocol was biennial screening from 60 to 69 years of age, with almost three times more deaths avoided than biennial screening from 50 to 59 years of age, with a similar number of deaths avoided by biennial screening from 50 to 69 years of age and with the greatest net benefit. Compared with the best scenario of annual screening from 40 to 49 years of age, the NNS of the protocol with biennial screening from 60 to 69 years of age was three-fold lower. Even in its best scenario, the addition of annual screening from 40 to 49 years of age to biennial screening from 50 to 69 years of age results in a decreased net benefit. However, even in the 50–69 year age group, the estimated reduction in breast cancer mortality for Brazil was half that estimated for the United Kingdom.

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Section: Discussionmentioning

confidence: 99%

Harms and benefits of mammographic screening for breast cancer in Brazil

Migowski,

Nadanovsky,

Manso de Mello Vianna

2024

PLoS ONE

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Radiation-induced dermatitis: a review of current understanding

Krasnoselskyi,

Artamonova,

Pavlichenko

2024

УРОЖ

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Background. Prevention and treatment of radiation-induced dermatitis that occurs after radiation therapy (RT) significantly impairs the quality of life of patients, among which the most severe are pain and discomfort caused by radiation dermatitis (RD). Purpose. Assess the condition and modern ideas of the development of technologies of prevention and treatment of radiation-induced dermatitis. Materials and Methods. A literature review based on massive digital publications found in the world resources of Scopus and Web of Science Core Collection for 2019–2023. With restrictions on the filters «Years», «Medicine» and «Articles». Results. Information on the terminology «radiation-induced dermatitis», risk factors for RD, some views on the mechanisms associated with their occurrence, and current ideas about their prevention and treatment were systematized. The leading countries – USA and China, leading scientific institutions –(Institut Curie, France; The University of Texas MD Anderson Cancer Center, USA; German Cancer Research Center and Universitätsklinikum Bonn, Germany, and University of Toronto and Sunnybrook Health Sciences Center, Canada, and their scientific topics were identified. Conclusion: The bibliometric analysis of current ideas about the prevention and treatment of RD allowed us to assess the current state and contribution of leading countries and scientific organizations to the development of innovative technologies for the prevention and treatment of RID. The most cited publications were identified, which indicates their high importance and the availability of a wide range of modern tools aimed at reducing and alleviating the manifestations of RD. In the future, it is desirable to create high-quality systematic reviews that will substantiate standardized, best practices for the prevention and treatment of RD for clinical use.

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Cicaderma® in radiation–related dermatitis of breast cancer: Results from the multicentric randomised phase III CICA-RT

Cited by 2 publications

References 44 publications

Harms and benefits of mammographic screening for breast cancer in Brazil

Harms and benefits of mammographic screening for breast cancer in Brazil

Radiation-induced dermatitis: a review of current understanding

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