Cicatricial Pemphigoid and Rheumatoid Arthritis

Spigel, G. Thomas

doi:10.1001/archderm.1978.01640150051016

Cited by 29 publications

(7 citation statements)

References 19 publications

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“…There are several reports on the coexistence of MMP and PV with other autoimmune diseases. MMP has been reported in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (25)(26)(27)(28)(29)(30). PV has also been reported in patients with SLE, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, systemic sclerosis, and polymyositis (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41).…”

mentioning

confidence: 99%

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

Sami

Bhol

Beutner³

et al. 2001

Clinical Immunology

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confidence: 99%

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

Sami

Bhol

Beutner³

et al. 2001

Clinical Immunology

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“…BP has been reported in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome, myasthenia gravis (MG) and multiple sclerosis (MS) [78][79][80][81][82][83][84][85][86][87][88][89]. MMP has been reported in patients with SLE, connective tissue disease (CTD) and RA [90][91][92][93][94][95]. Also, PV has been reported with SLE, CTD, MS, MG, alopecia universalis, insulin-dependent diabetes mellitus, autoimmune thyroid disease, Sjögren's syndrome and systemic sclerosis [96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113].…”

Section: Maaagqlcllylsagllsrlgaafnldtrednvirkygdpgslfgfslamhwqlqp Edkmentioning

confidence: 99%

Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously

Zakka

Keskin

Reche

et al. 2010

Clinical and Experimental Immunology

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SummaryIn this report, we present 15 patients with histological and immunopathologically proven pemphigus vulgaris (PV). After a mean of 80 months since the onset of disease, when evaluated serologically, they had antibodies typical of PV and pemphigoid (Pg). Similarly, 18 patients with bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) were diagnosed on the basis of histology and immunopathology. After a mean of 60 months since the onset of disease, when their sera were evaluated they were found to have Pg and PV autoantibodies. In both groups of patients the diseases were characterized by a chronic course, which included several relapses and recurrences and were non-responsive to conventional therapy. The major histocompatibility complex class II (MHC II) genes were studied in both groups of patients and phenotypes associated typically with them were observed. Hence, in 33 patients, two different pathogenic autoantibodies were detected simultaneously. The authors provide a computer model to show that each MHC II gene has relevant epitopes that recognize the antigens associated with both diseases. Using the databases in these computer models, the authors present the hypothesis that these two autoantibodies are produced simultaneously due to the phenomena of epitope spreading.

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“…Another study by Foster on a series of 130 patients followed for cicatricial pemphigoid noted the presence of autoimmune diseases associated in 17.7%, which is significantly higher compared to the 4% risk observed in the general population [5]. Associations reported in this context are lupus [7], rheumatoid arthritis [8], or mixed connectivitis [9,10].…”

Section: Observationmentioning

confidence: 97%

Multiple Autoimmune Syndrome with Vitiligo, Autoimmune Thrombocytopenia and Autoimmune Dermoepidermal Bullous Dermatosis

Amraoui¹

2015

Int J Dermatol Clin Res

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Multiple auto-immune syndrome is defined by the coexistence of at least three different autoimmune diseases. Immune genetic predisposition and abnormalities of humeral and cell-mediated immunity seems to be implicated in their genesis.In this observation, we describe a combination of three autoimmune diseases in the same patient namely vitiligo evolving since childhood, autoimmune dermo epidermal bullous dermatosis and autoimmune thrombocytopenia. The discovery of such associations may limit the therapeutic arsenal. And temporal sequence indicates that long-term surveillance of these patients is necessary to watch the occurrence of another autoimmune disease.According to the clinical context and the results of immune histology we retained in our patient the combination of three autoimmune diseases: vitiligo, autoimmune thrombocytopenia with autoimmune bullous derma epidermal dermatitis most probably cicatricle pemphigoid. Epidermolysis bullosa acquisita that looks like cicatricle pemphigoid cannot be ruled out given the lack of examination by immune-microscopy.The patient was initially put on oral corticosteroids at a dose of 1mg / kg / day until normalization of platelet levels. Then treatment with daps one at a dose of 2 mg / kg / day associated with mycofenolate mofetil at a rate of 2g / day was initiated with a clinical and laboratory monitoring. The evolution was marked by the stabilization of the disease and a slight improvement in ocular involvement. DisscussionWe report a unique case characterized by the association of vitiligo, an autoimmune thrombocytopenia and autoimmune dermo epidermal bullous dermatosis in a male patient. It is still uncommon IntroductionMultiple autoimmune syndrome is defined by the coexistence of at least three different autoimmune diseases which can occur simultaneously or over several years of evolution. We report an exceptional association of vitiligo, autoimmune thrombocytopenia and autoimmune dermoepidermal bullous dermatosis. ObservationA young patient of 35 years presented since the age of 14 achromic non-painful or pruritic lesions which gradually extended to the level of the body. 4 years ago he developed intermittent oral and nasal erosions associated with red eyes and a decrease of visual acuity impeding his daily and professional activities. He also reported episodic appearance of some liquidiennes skin lesions without signs of infection or systemic disease.Ocular examination revealed bilateral red eyes with Symblepharon, and corneal dystrophy (Figure 1). Cutaneous examination revealed at the left leg the presence of tense bullae with clear contents based on healthy skin, associated with hemorrhagic erosions (Figure 2). The Nikolsky's sign was negative. There were also extensive achromic patches (Figure 3). Laboratory test showed thrombocytopenia at 32000 / mm3. We completed the investigation by sternal puncture which showed a hypercellular marrow with megakaryocytic hyperplasia in support of a peripheral autoimmune origin. Thyroid and anti-nuclear antibody wer...

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Cicatricial Pemphigoid and Rheumatoid Arthritis

Cited by 29 publications

References 19 publications

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously

Multiple Autoimmune Syndrome with Vitiligo, Autoimmune Thrombocytopenia and Autoimmune Dermoepidermal Bullous Dermatosis

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