Cicatricial pemphigoid of the scalp mimicking discoid lupus erythematosus

Das, Shinjita; Blanco, Gabriela; Ahmed, Ammar M.; Tran, Kien Trung; Matthews, Loderick A.; Pandya, Amit G.

doi:10.1016/j.jaad.2010.10.028

Cited by 11 publications

(3 citation statements)

References 3 publications

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“… 59 Erythematous scarring plaques with dyspigmentation and atrophy on the scalp of an African–American patient were initially treated as DLE, but were eventually diagnosed as pemphigoid after histopathology and DIF were performed. 60 Sarcoidal alopecia and scalp DLE have similar clinical and dermoscopic features, and can only be differentiated by histopathological examination. 61 …”

Section: Lupus-specific Alopeciamentioning

confidence: 99%

Alopecias in lupus erythematosus

Concha

Werth

2018

Lupus Sci Med

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Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Alopecia areata can coexist with LE and may mimic DLE. Non-lupus alopecias such as telogen effluvium and anagen effluvium have a myriad of causes which include disease flares, drugs and stress in the setting of LE. The latest validated Systemic Lupus International Collaborating Clinics classification criteria for SLE includes non-scarring alopecia as a criterion; therefore, recognising the aetiology of hair loss in the setting of LE is crucial in classifying a patient to have systemic disease.

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Section: Lupus-specific Alopeciamentioning

confidence: 99%

Alopecias in lupus erythematosus

Concha

Werth

2018

Lupus Sci Med

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“…CR, complete response; NR, no response; PR, partial response. Localized erythematous plaque near affected mucosal surfaces, generalized bullous eruption particularly on the head and upper body, or vegetating lesions occasionally 102,103 Scarring, cicatricial alopecia on the scalp 104,105 Oral cavity In over 85% of patients…”

Section: Discussionmentioning

confidence: 99%

Mucous membrane pemphigoid

2020

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Autoantibodies to one or several autoantigens in the mucosal or epithelial BMZ have been identified in MMP patients. 4-10 The association of MMP with human leukocyte antigen (HLA) major histocompatibility class II HLA-DQB1*0301 has been demonstrated. 11-13 The cause is usually unknown, but there are a few reports of MMP triggered by medications such as methyldopa, clonidine and D-penicillamine. 14, 15 EPIDEMIOLOGY The true incidence of MMP is unclear. A recent study from the United Kingdom demonstrated that ocular MMP accounted for 61% of the cases of newly diagnosed cicatricial conjunctivitis and the incidence was calculated as 0.8 per million population. 16 The incidence of MMP was estimated to be 1.3-2.0 per million per year in France and Germany. 17, 18 MMP predominantly affects women more often than men with a male to female ratio of nearly 2:1. 19 MMP mainly occurs in the elderly population, commonly observed between 60 and 80 years of age. 20 Albeit rare, children may also be affected. Approximately 20 cases of childhood onset MMP have been reported, among whom the youngest one was 10 months old. 21-23 There is no known racial or geographic predilection.

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“…Skin In 25-30% of patients 19 Localized erythematous plaque near affected mucosal surfaces, generalized bullous eruption particularly on the head and upper body, or vegetating lesions occasionally 102,103 Scarring, cicatricial alopecia on the scalp 104,105 Oral cavity In over 85% of patients Desquamative gingivitis, erosions, ulceration ( Fig. 1) Pseudomembrane Vesicles rarely seen (Fig.…”

Section: Sites Involved Presentations and Potential Complicationsmentioning

confidence: 99%

Mucous Membrane Pemphigoid

Kirtschig¹,

Wojnarowska²

SpringerReference

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Cicatricial pemphigoid of the scalp mimicking discoid lupus erythematosus

Cited by 11 publications

References 3 publications

Alopecias in lupus erythematosus

Alopecias in lupus erythematosus

Mucous membrane pemphigoid

Mucous Membrane Pemphigoid

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