To develop a navigation program for patients undergoing hematopoietic stem cell transplantation. Method: The study followed the convergent care research methodology, which provides the researcher's participatory insertion in the field of care practice. The navigation program was divided into four stages: diagnosis, planning, implementation and evaluation. The diagnostic stage consisted of understanding the sector's routine and listing the barriers faced by patients. In the planning phase, the program and its operation were structured. The implementation took place through a pilot study with patients undergoing transplantation. In the evaluation stage, the data were analyzed using the continuous improvement tool (Plan, Do, Check and Correct). Results: The sample consisted of 21 adult patients. The most frequent pathology was acute lymphocytic leukemia, the prevalent sex was male, two patients died during the preparation for the procedure, and only one required readmission after hospital discharge. Conclusion: The development of a navigation program proved to be essential for the adaptation of the patient and family to the new sector and routine, and contributed to greater user satisfaction.