Ciclopirox gel for seborrheic dermatitis of the scalp

Aly, Raza; Katz, H. Irving; Kempers, Steven; Lookingbill, Donald P.; Lowe, Nicholas J.; Menter, Alan; Morman, Manuel R.; Savin, Ronald C.; Wortzman, Mitchell

doi:10.1046/j.1365-4362.42.s1.5.x

Cited by 24 publications

(24 citation statements)

References 2 publications

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“…Twice-daily for 4 weeks Rapid, significant improvement Change from baseline mean score for total signs significant in favour of ciclopirox group [68] n: Number of patients; SD: Seborrhoeic dermatitis.…”

Section: Treatmentmentioning

confidence: 98%

Seborrhoeic dermatitis: current treatment practices

Gupta

Kogan

2004

Expert Opinion on Pharmacotherapy

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Seborrhoeic dermatitis (SD) is a recurrent, chronic inflammation of the skin that occurs on sebum rich areas such as the face, scalp and chest, characterised by red scaly lesions. The are many studies indicating that Malassezia yeasts play an important role in the aetiology of this condition, most of the evidence for which comes from demonstrated responsiveness to treatment with antifungal agents. Its aetiology, however, is far from being resolved. Some believe that it is the immune response of the skin to the Malassezia that is the cause of the disease. Traditional treatments of SD have been the use of keratolytic agents or corticosteroids. Since the discovery of ketoconazole, a considerable amount of research has been focused on determining the efficacy of various antifungal agents. This article reviews clinical trial data on treatment options available for SD.

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Section: Treatmentmentioning

confidence: 98%

Seborrhoeic dermatitis: current treatment practices

Gupta

Kogan

2004

Expert Opinion on Pharmacotherapy

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“…Low-potency corticosteroids may be useful in providing an anti-inflammatory effect, though many newer antifungal agents such as ciclopirox may also provide anti-inflammatory activity comparable to corticosteroids [54]. Ciclopirox (cream, gel or shampoo) provides effective antifungal treatment, and also has antibacterial and anti-inflammatory activities [55,56]. Zinc pyrithione shampoos are safe and effective in controlling dandruff and SD of the scalp, and exhibit strong keratolytic and antifungal activity against Malassezia [16,57].…”

Section: Seborrheic Dermatitismentioning

confidence: 99%

Dermatophytosis (Tinea) and Other Superficial Fungal Infections

Welsh

González

2015

Diagnosis and Treatment of Fungal Infections

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“…Aly et al [14] in a multicenter, randomised, double-blind vehicle controlled study of 178 subjects, evaluated the efficacy of ciclopirox gel (0.77%) twice daily, in the treatment of seborrheic dermatitis of the scalp. The confirmed change from baseline and mean score for total signs and symptoms was significantly greater in ciclopirox subjects compared with vehicle subjects.…”

Section: Ciclopirox Olamine In Seborrheic Dermatitismentioning

confidence: 99%

The safety and efficacy of ciclopirox olamine for the treatment of seborrheic dermatitis

Starova¹,

Aly

2005

Expert Opinion on Drug Safety

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Ciclopirox olamine is a synthetic hydroxypiridone derived, broad spectrum, antifungal agent which has been used effectively to treat seborrheic dermatitis. Seborrheic dermatitis is a chronic dermatosis, more common in men than women, which usually occurs in sites dense with sebaceous glands in the form of mild inflammatory desquamate erythema. Treatment modalities for seborrheic dermatitis include keratolytic agents, corticosteroids and antifungal agents. Due to its antimycotic and anti-inflammatory activities, ciclopirox olamine is established as an effective treatment for this condition.

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Ciclopirox gel for seborrheic dermatitis of the scalp

Abstract: Ciclopirox gel is effective and safe in the treatment of seborrheic dermatitis of the scalp.

Cited by 24 publications

References 2 publications

Seborrhoeic dermatitis: current treatment practices

Seborrhoeic dermatitis: current treatment practices

Dermatophytosis (Tinea) and Other Superficial Fungal Infections

The safety and efficacy of ciclopirox olamine for the treatment of seborrheic dermatitis

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