Cigarette smoke as a source of pesticide exposure

Dorough, H. W.; Atallah, Y. H.

doi:10.1007/bf01684872

Cited by 13 publications

(8 citation statements)

References 3 publications

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“…Mirex was found in the lungs (36%), blood ( 11 %), and hearts ( 1 %) of rats exposed to mirex in cigarette smoke Dorough and Atallah, 1975). The exposure concentration was not reported.…”

Section: Distributionmentioning

confidence: 91%

“…Inhalation Exposure Very limited data show that inhaled mirex can be rapidly absorbed into the blood of rats Dorough and Atallah, 1975). The fate of [14C] mirex in cigarette smoke in rats was assessed using a smoking device Dorough and Atallah, 1975). Eight 5-ml puffs were administered to the trachea of rats at 15-second intervals.…”

Section: Cancermentioning

confidence: 99%

“…Only very limited animal data were located regarding the distribution of mirex following inhalation exposure Dorough and Atallah, 1975). Mirex was found in the lungs (36%), blood ( 11 %), and hearts ( 1 %) of rats exposed to mirex in cigarette smoke Dorough and Atallah, 1975).…”

Section: Distributionmentioning

confidence: 99%

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Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Additional substances will be profiled in a series of manuscripts to follow.

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“…Mirex was found in the lungs (36%), blood ( 11 %), and hearts ( 1 %) of rats exposed to mirex in cigarette smoke Dorough and Atallah, 1975). The exposure concentration was not reported.…”

Section: Distributionmentioning

confidence: 91%

Section: Cancermentioning

confidence: 99%

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Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

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“…In addition to nicotine, tobacco smoke contains multiple other chemicals, including many pesticides used in the agricultural production of tobacco (5). Among the most common of these are the organophosphates and, to a lesser extent, carbamate pesticides (6,7). Chronic low level exposure to these toxins can result in an accumulation within body fat stores not only of the primary toxins but also of many metabolites (8).…”

mentioning

confidence: 99%

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study

Leigh

Viner²,

Cox

et al. 2001

Canadian Respiratory Journal

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“…Literature regarding carbofuran aerosol disposition is unavailable. Carbofuran fate studies, as an insecticide residue of inhaled cigarette smoke was described by general patterns of inhaled I4C vapor elimination [9,10]; however, toxicity was not studied. Aerosol inhalation studies of organophosphate pesticides [ 1 1 -131 did relate patterns of irreversible acetylcholinesterase inhibition with pesticide inhalation, though no correlations with patterns of biotransformation were made nor was inhaled dose accurately confirmed.…”

Section: P W Fekcuson Et Aimentioning

confidence: 99%

Carbofuran disposition in the rat after aerosol inhalation

Ferguson

Jewell

Krieger

et al. 1982

Enviro Toxic and Chemistry

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-[14C-]Carbonyl carbofuran toxicity, metabolism and pharmacokinetics in male Sprague-Dawley rats were studied after 4.1 pm (50 min, 0.2 and 1.2 pglL) and 1.5 pm (70 min, 0.2 pglL) aerodynamic diameter monodisperse aerosol exposures. Regional carbofuran deposition for each particle size was similar to human and rodent models for insoluble aerosols. Total carbofuran deposition was greater than expected in the rodent model but similar to that in human models.3-Hydroxycarbofuranlcarbofuran ratios in gastrointestinal tract and liver (1.3,3 X greater after 4.1 pm) provided additional deposition indices. Rapid in vitro solubility t,,, (17 min) for 4.1 pm particles and minimal differences in plasma carbamate (% total ''Clanimal) after varied particle size exposure indicated primary clearance by dissolution, irrespective of deposition site. Carbofuran (1.2 pg/L, 4.1pm) inhibited red blood cell acetylcholinesterase (55% at 10 min postexposure with recovery by 2 h). Eight-hour I4C metabolic fate in I4CO, (3 1-38%), urine (9-12%), feces (2-5.5%) and carcass (44-58%) were similar for each particle size. Carbamate pharmacokinetics measured for 2 h postexposure to 4.1 prn particles described monoexponential elimination. Plasma half-lives for carbofuran (36 min) and 3-hydroxycarbofuran (62 min) were similar to those previously determined after oral and i.v. exposures.

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Cigarette smoke as a source of pesticide exposure

Cited by 13 publications

References 3 publications

Atsdr Evaluation of Health Effects of Chemicals

Atsdr Evaluation of Health Effects of Chemicals

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study

Carbofuran disposition in the rat after aerosol inhalation

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