Cigarette Smoke Exposure and Angiogenic Factors in Pregnancy and Preeclampsia

Jeyabalan, Arun; Powers, Robert W.; Durica, Allison R.; Harger, Gail; Roberts, James M.; Ness, Roberta B.

doi:10.1038/ajh.2008.219

Cited by 95 publications

(75 citation statements)

References 24 publications

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“…The mechanism leading to this outcome is currently unknown, but may include changes to maternal and placental angiogenic factors, endothelial function and immune responses, induced by cigarette smoking, all of which contribute to this disease pathology. In support of this, a recent study found an association between smoking in pregnancy and reduced levels of the angiogenic factor soluble FMS-like tyrosine kinase-1 in maternal circulation [41]. Further research is required to elucidate the organs effecting and affected by this change, and to identify whether these same pathways are conversely affected with asthma.…”

Section: Discussionmentioning

confidence: 58%

Perinatal outcomes following maternal asthma and cigarette smoking during pregnancy

et al. 2013

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Does cigarette smoking in pregnancy explain the increased risk of adverse perinatal outcomes that occur with maternal asthma or does it compound the effect?Using population based birth records, a retrospective analysis was conducted of all singleton pregnancies in South Australia over 10 years (1999-2008; n5172 305), examining maternal asthma, cigarette smoking and quantity of smoking to estimate odds ratios.Compared with nonasthmatic females who did not smoke during pregnancy, both asthmatic females who smoked and those who did not smoke during pregnancy had a significantly increased risk of gestational diabetes, antepartum haemorrhage, polyhydramnios, premature rupture of membranes, emergency Caesarean section, and the child being small for gestational age and having congenital abnormalities. These associations suggest that asthma, independently of maternal smoking, increases the risk of these adverse perinatal outcomes. Maternal smoking was itself associated with an increased risk of a number of poor neonatal outcomes, with a dose-response relationship observed. Notably, maternal asthma combined with cigarette smoking significantly increased the risk of preterm birth and urinary tract infections to a greater degree than with either exposure alone.Maternal asthma and cigarette smoking during pregnancy are both independently associated with adverse perinatal outcomes and, combined, compound the risk of preterm birth and urinary tract infections. @ERSpublications Asthma and smoking are independently associated with adverse perinatal outcomes and compound the effect in combination

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Section: Discussionmentioning

confidence: 58%

Perinatal outcomes following maternal asthma and cigarette smoking during pregnancy

et al. 2013

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“…19,35 Cigarette smoking was previously shown to be associated with lower maternal sFlt-1 concentrations in uncomplicated pregnancy and pre-eclampsia. 45 In addition, overweight women with pre-eclampsia were demonstrated to have lower levels of sFlt-1 and higher levels of PlGF than pre-eclamptic women of normal weight. 46 Nevertheless, the narrow range of gestational age at blood collection, as well as the low number of smokers and pre-eclamptic patients of normal weight in this study, did not allow us to confirm these data.…”

Section: Discussionmentioning

confidence: 95%

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

et al. 2010

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The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased placental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of the patients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of 54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case-control study. Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF were significantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition, pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a disease onset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showed significant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorder.

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“…18 Earlier studies indicate that cigarette smokers have lower circulating levels of sFlt1 than nontobacco users. 19,20 In vitro studies have reported that carbon monoxide, a major component in combustion, diminishes sFlt1 release from cultured endothelial cells, 21 whereas nicotine does not influence the production of sFlt1 from cultured placental cells. 22 Our findings of a lower risk of preeclampsia in cigarette smokers, who are exposed to carbon monoxide, but not in snuff users, who are only exposed to nicotine, are in agreement with these results.…”

Section: Wikström Et Al Effect Of Tobacco On Preeclampsiamentioning

confidence: 99%

Tobacco Use During Pregnancy and Preeclampsia Risk

Wikström

Stephansson²,

Cnattingius³

2010

Hypertension

159

131

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Abstract-Preeclampsia is a leading cause of maternal and infant mortality and morbidity worldwide. Both Swedish snuff and cigarette smoke include nicotine, but combustion products accompany only smoking. The aims of this study were to compare the effects of Swedish snuff and cigarette smoking on preeclampsia risk and to estimate whether changes in tobacco habits during pregnancy affect the risk of developing term preeclampsia. We used information from the Swedish Birth Register on all singleton births in Sweden during the years 1999 -2006 (nϭ612 712). Compared with nontobacco users, women who used snuff in early pregnancy had an adjusted odds ratio (OR) for preeclampsia of 1.11 (95% CI: 0.97 to 1.28). The corresponding ORs for light and heavy smokers were 0.66 (95% CI: 0.61 to 0.71) and 0.51 (95% CI: 0.44 to 0.58), respectively, with ORs lower for term than preterm preeclampsia. Compared with nontobacco users, women who smoked in early pregnancy but had quit smoking before late pregnancy (weeks 30 to 32) had an adjusted OR for term preeclampsia of 0.94 (95% CI: 0.83 to 1.08). The corresponding OR for women who did not use tobacco in early pregnancy but had started to smoke before late pregnancy was 0.65 (95% CI: 0.50 to 0.85). We conclude that tobacco combustion products rather than nicotine are the probable protective ingredients against preeclampsia in cigarette smoke. Because change of smoking habits during pregnancy influence risk, we further conclude that it is the smoking habits in the middle or late rather than in the beginning of pregnancy that seem to affect the risk of preeclampsia. (Hypertension. 2010;55:1254-1259.)

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Cigarette Smoke Exposure and Angiogenic Factors in Pregnancy and Preeclampsia

Abstract: Cigarette smoking is associated with lower maternal sFlt-1 concentrations during pregnancy and preeclampsia. On the basis of these data, cigarette smoke exposure may decrease the risk of preeclampsia in part by moderating the anti-angiogenic phenotype observed in the syndrome.

Cited by 95 publications

References 24 publications

Perinatal outcomes following maternal asthma and cigarette smoking during pregnancy

Perinatal outcomes following maternal asthma and cigarette smoking during pregnancy

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

Tobacco Use During Pregnancy and Preeclampsia Risk

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