Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a Japanese Population

Kiyohara, Chikako; Washio, Masakazu; Horiuchi, Takahiko; Asami, Toyoko; Ide, Seiji; Atsumi, Tatsuya; Kobashi, Gén; Tada, Yutaka; Takahashi, Hiroki

doi:10.3899/jrheum.111609

Cited by 56 publications

(55 citation statements)

References 46 publications

(38 reference statements)

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“…Many environmental factors have been investigated, and, for example, compelling evidence has associated silica quartz dust and Epstein Barr virus exposure with increased SLE risk [4-7]. More recently, meta-analyses have shown an association with smoking [8, 9]. Other studies have assessed the role of solvents, insecticides, and lipstick, though their outcomes have not yielded reliable associations [10-13].…”

Section: Introductionmentioning

confidence: 99%

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Lu-Fritts

Kottyan

James

et al. 2014

Arthritis & Rheumatology

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Objective Explore the hypothesis that cases of SLE will be found more frequently in community members with high prior uranium exposure in the Fernald Community Cohort (FCC). Methods A nested case control study was performed. The FCC is a volunteer population that lived near a uranium ore processing plant in Fernald, Ohio, USA during plant operation and members were monitored for 18 years. Uranium plant workers were excluded. SLE cases were identified using American College of Rheumatology classification criteria, laboratory testing, and medical record review. Each case was matched to four age-, race-, and sex-matched controls. Sera from potential cases and controls were screened for autoantibodies. Cumulative uranium particulate exposure was calculated using a dosimetry model. Logistic regression with covariates was used to calculate odds ratios (OR) with 95% confidence intervals (CI). Results The FCC includes 4,187 individuals with background uranium exposure, 1,273 with moderate exposure, and 2,756 with higher exposure. SLE was confirmed in 23 of 31 individuals with a lupus ICD9 code, and in 2 of 43 other individuals prescribed hydroxychloroquine. The female:male ratio was 5.25:1. Of the 25 SLE cases, 12 were in the higher exposure group. SLE was associated with higher uranium exposure (OR 3.92, 95% CI 1.131-13.588, p = 0.031). Conclusion High uranium exposure is associated with SLE relative to matched controls in this sample of uranium exposed individuals. Potential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure.

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Section: Introductionmentioning

confidence: 99%

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Lu-Fritts

Kottyan

James

et al. 2014

Arthritis & Rheumatology

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“…Moderate alcohol consumption inhibits production of IL-6 (49). It has been suggested that ethanol or its metabolites, rather than specific substances in alcoholic beverages, may modulate cytokine release, which, in turn, will decrease SLE risk (10). Beer is the most popular alcoholic beverage in our study population, followed by wine, sake (Japanese rice wine), and shochu (Japanese distilled spirit) (data not shown).…”

Section: Discussionmentioning

confidence: 82%

“…A meta-analysis suggested that moderate alcohol consump-tion, compared with no consumption, was significantly associated with decreased SLE risk (summary odds ratio [OR] 0.66, 95% confidence interval [95% CI] 0.49 -0.89) based on 5 studies (9). Similarly, our recent study found that light to moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage (10). Women who consumed Ͼ200 ml of coffee/day had increased inflammation markers, such as interleukin-6 (IL-6) and tumor necrosis factor ␣, compared with coffee nondrinkers (11).…”

Section: Introductionmentioning

confidence: 82%

Modifying Effect of N‐Acetyltransferase 2 Genotype on the Association Between Systemic Lupus Erythematosus and Consumption of Alcohol and Caffeine‐Rich Beverages

Kiyohara

Washio

Horiuchi

et al. 2014

Arthritis Care & Research

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Objective. N-acetyltransferase 2 (NAT2) is involved in the metabolism of various environmental substances, both with and without carcinogenic potential. Alcoholic and nonalcoholic caffeine-rich beverages may be associated with markers of inflammation. Systemic lupus erythematosus (SLE) is a chronic, multifaceted inflammatory disease. We investigated the effects of alcoholic and nonalcoholic caffeine-rich beverages on risk of SLE and determined whether the effects were modified by NAT2 status. Methods. The NAT2 polymorphism was genotyped in 152 SLE cases and 427 healthy controls, all women and Japanese. We assessed effect modification by testing an interaction term for the NAT2 polymorphism and consumption of beverages. Results. Consumption of black tea (odds ratio [OR] 1.88, 95% confidence interval [95% CI] 1.03-3.41) and coffee (OR 1.57, 95% CI 0.95-2.61), but not green tea, was associated with an increased risk of SLE, while alcohol use (OR 0.33, 95% CI 0.20 -0.55) was associated with a decreased risk of SLE. There were significant interactions between the NAT2 polymorphism and either alcohol use (P interaction ‫؍‬ 0.026) or consumption of black tea (P interaction ‫؍‬ 0.048). Conclusion. The NAT2 polymorphism significantly modified the effects of alcohol use and black tea consumption on SLE, emphasizing the importance of incorporating genetic and metabolic information in studies on management of SLE. Additional studies are warranted to confirm the findings suggested in this study.

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“…On the other hand, moderate/reasonable alcohol intake has been reported to confer a protective effect. [12][13][14] Even though there are many potential causes of pleural effusion and congestive heart failure (CHF), the most common etiologic factors include malignancy, pneumonia and pulmonary embolism. Several disorders may cause effusion, despite the involvement of many different organs.…”

Section: -10mentioning

confidence: 99%

Massive pleural effusion in a patient with systemic lupus erythematosus

Yavsan¹,

Karahan²,

Şahin³

et al. 2015

IJRCI

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Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a Japanese Population

Abstract: Our results suggest that smoking was positively associated with increased SLE risk whereas light/moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage. Additional studies are warranted to confirm these findings.

Cited by 56 publications

References 46 publications

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Association of Systemic Lupus Erythematosus With Uranium Exposure in a Community Living Near a Uranium‐Processing Plant: A Nested Case–Control Study

Modifying Effect of N‐Acetyltransferase 2 Genotype on the Association Between Systemic Lupus Erythematosus and Consumption of Alcohol and Caffeine‐Rich Beverages

Massive pleural effusion in a patient with systemic lupus erythematosus

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