Cigarette smoking and chronic kidney diseases

Nagasawa, Yasuyuki; Yamamoto, Ryohei; Rakugi, Hiromi; Isaka, Yoshitaka

doi:10.1038/hr.2011.205

Cited by 62 publications

(43 citation statements)

References 47 publications

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“…Consistent with earlier reports, the present data demonstrated that gender, smoking, drinking, proteinuria and eGFR were associated with the kidney survival time of CKD patients (25)(26)(27)(28), which confirmed the validity of the data. The mechanism explained the association among smoking, drinking and CKD progression is that smoking and drinking all contribute to oxidative stress, which plays an important role in the development and progression of CKD (29).…”

Section: Discussionsupporting

confidence: 81%

Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients

Cui

Bai

et al. 2015

Biomedical Reports

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Abstract. Uromodulin (UMOD) is the most abundant protein secreted in urine and the mutated form of the UMOD gene is associated with UMOD-associated kidney disease (UAKD). Although UMOD accumulates in the kidney of UAKD patients, it is unclear whether this also occurred in the chronic kidney disease (CKD) patients. Therefore, the association of single-nucleotide polymorphisms (SNPs) in the promoter region of UMOD gene with the kidney survival time of CKD was investigated. The promoter region of the UMOD gene was sequenced for 111 CKD patients. The Kaplan-Meier method was used to identify the disease outcome associated with SNPs in the promoter region of the UMOD gene in CKD patients. The Cox proportional hazard model was used to identify risk factors for the kidney survival time of CKD. SNPs in reference to GenBank accession NG-000016 were detected at 23 sites of the 481-bp in the UMOD promoter region from the CKD patients and the healthy controls. The 6 SNPs with minor allele frequency >5% in the CKD patients or controls were used for disease risk and outcome analysis. The frequent allele rs13333226AA was associated with a shorter period of kidney survival time in CKD patients (P=0.005). The length of kidney survival time in CKD patients with the rs13333226AA genotype was significantly shorter than that of patients with the frequent allele rs13333226AG+GG (relative risk, 0.361; 95% confidence interval, 0.171-0.761; P= 0.007). In conclusion, analysis of genetic polymorphisms in UMOD may help to identify the CKD patient subgroups at a high risk for a disease outcome, thereby helping to refine therapeutic decisions in CKD patients.

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Section: Discussionsupporting

confidence: 81%

Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients

Cui

Bai

et al. 2015

Biomedical Reports

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“…Consistent with earlier reports, our data demonstrated smoking and gender were associated with the CKD progression, [29][30][31][32][33] which confirmed the validity of our data. The mechanism explained the relationship between smoking and CKD progression is that smoking contribute to oxidative stress, which plays important role in the development and progression of CKD.…”

supporting

confidence: 82%

Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with the kidney survival time in chronic kidney disease patients

Guo

Bai

et al. 2014

Renal Failure

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In the present study, we identified 20 SNPs with a frequency higher than 5% and assessed the relationship of these SNPs with kidney survival time in CKD patients, a SNP of 146 was identified by log-rank test for statistically significant prediction of the kidney survival time.In an overall multivariate analysis, allele 146 was identified as an independent predictor of kidney survival time in CKD patients. The survival time of kidney in the CKD patients with 146C was significantly shorter than that of kidney in CKD patients with 146T (relative risk, 2.336; 95% CI, 1.319-3.923; p ¼ 0.001). Conclusion: SNPs in the D-loop can predict the kidney survival of CKD patients. Analysis of genetic polymorphisms in the mitochondrial D-loop can help to identify CKD patient subgroup at high risk of a poor disease outcome.

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“…In addition to hypertension, diabetes mellitus and metabolic syndrome, the incidence of CKD is also closely correlated with unhealthy lifestyle behaviors such as smoking, heavy alcohol intake, obesity, physical inactivity and an unhealthy diet [7][8][9][10][11][12]. Moreover, it is well known that a decreased physical activity and aerobic capacity are predictive factors for the prognosis in ESRD patients [13,14].…”

Section: Introductionmentioning

confidence: 99%

The accumulation of healthy lifestyle behaviors prevents the incidence of chronic kidney disease (CKD) in middle-aged and older males

Michishita

Matsuda

Kawakami

et al. 2016

Environ Health Prev Med

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Aim This study was retrospectively designed to evaluate the influence of healthy lifestyle behaviors on the incidence of chronic kidney disease (CKD) during a 5-year follow-up period in middle-aged and older males. Methods The subjects included 252 males without a history of cardiovascular disease, stroke, renal dysfunction and/or dialysis treatment who were not taking any medications. Their lifestyle behaviors were evaluated using a standardized self-administered questionnaire and defined as follows: (1) habitual moderate exercise, (2) daily physical activity, (3) fast walking speed, (4) slow eating speed, (5) no late-night dinner, (6) no bedtime snacking and (7) no skipping breakfast. The participants were divided into four categories, which were classified into quartile distributions according to the number of healthy lifestyle behaviors (7-6, 5, 4 and B3 groups). Results After 5 years, the incidence of CKD [estimated glomerular filtration rate (eGFR)\60 ml/min/1.73 m 2 and/ or proteinuria] was observed in 23 subjects (9.1 %). The Kaplan-Meier survival curves showed that the cumulative incidence of CKD significantly decreased according to an increase in the number of healthy lifestyle behaviors (logrank test: p = 0.003). According to a multivariate analysis, habitual moderate exercise [hazard ratio (HR) 0.20, 95 % confidence of interval (CI) 0.06-0.69, p = 0.011] and no bedtime snacking (HR 0.19,, p = 0.004) were significantly associated with the incidence of CKD. Conclusions These results suggest that the accumulation of healthy lifestyle behaviors, especially those related to habitual moderate exercise and no bedtime snacking, is considered to be important to reduce the risk of CKD.

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Cigarette smoking and chronic kidney diseases

Cited by 62 publications

References 47 publications

Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients

Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients

Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with the kidney survival time in chronic kidney disease patients

The accumulation of healthy lifestyle behaviors prevents the incidence of chronic kidney disease (CKD) in middle-aged and older males

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