Cigarette Smoking and Estrogen-Related Cancer

Baron, John A.; Nichols, Hazel B.; Anderson, Chelsea; Safe, Stephen

doi:10.1158/1055-9965.epi-20-1803

Cited by 21 publications

(11 citation statements)

References 184 publications

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“…Conversely, ndings from three large-scale cohort investigations indicate an inverse relationship between the duration of post-menopausal smoking and breast cancer risk, contrasting with a tendency towards increased risk in premenopausal smoker. This pattern mirrors observations in endometrial cancer, wherein post-menopausal smoking, but not premenopausal smoking, is associated with diminished risks [54] . Currently, there exists a paucity of studies pertaining to the association between smoking and breast pathologies, necessitating further investigation to elucidate the nexus between smoking and breast diseases.…”

Section: Discussionsupporting

confidence: 82%

The Relationship between Modifiable Lifestyle Factors and Breast Diseases: A Mendelian Randomization Study

Yang,

Wang,

Han

et al. 2024

Preprint

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Background This study aimed to employ mendelian randomization to systematically investigate the causal effects of genetic predispositions and modifiable lifestyle factors on breast diseases. MethodsIn this mendelian randomization study, we leveraged large-scale genetic data from genome-wide association studies (GWAS) to assess the causal effects of modifiable lifestyle factors. Instrumental variable analysis was performed using genetic variants associated with each lifestyle factor as instruments. Sensitivity analyses were conducted to assess the robustness of findings. Results We applied instrumental variable weighted (IVW) analysis to investigate causal link. Specifically, an increased risk of overall BC was observed with longer sleep duration (OR=1.33, 95% CI: 1.01-1.74, P=0.04) and decreased with more years of schooling (OR=0.91, 95% CI: 0.83-0.99, P=0.04) and greater fresh fruit intake (OR=0.64, 95% CI: 0.46-0.90, P=0.01). For ER+ BC, both increased sleep duration (OR=1.49, 95% CI: 1.12-2.00, P=0.007) and greater fresh fruit consumption (OR=0.65, 95% CI: 0.44-0.95, P=0.02) showed significant associations. In contrast, the risk of developing ER-BC decreased with increased education (OR=0.73, 95% CI: 0.64-0.84, P=0.000005) and fresh fruit intake (OR=0.55, 95% CI: 0.31-0.99, P=0.04) but increased with increased processed meat consumption (OR=1.78, 95% CI: 1.11-2.84, P=0.016). Benign neoplasm of breast was linked to higher physical activity levels (OR=3.13, 95% CI: 1.07-9.10, P=0.0368), more years of education (OR=0.63, 95% CI: 0.46-0.866, P=0.003), and greater processed meat consumption (OR=3.84, 95% CI: 1.25-11.84, P=0.019). Moreover, inflammatory disorders of breast were correlated with pack years of smoking (OR=4.18, 95% CI: 1.10-15.70, P=0.034), higher BMI (OR=1.97, 95% CI: 1.40-2.72, P=0.00004), and fewer years of schooling (OR=0.47, 95% CI: 0.29-0.77, P=0.003). These findings underscore the complexity of lifestyle influences on different types of breast pathologies and highlight the importance of considering specific disease mechanisms in lifestyle recommendations. Conclusions This MR study provides evidence supporting the significant role of modifiable lifestyle factors in breast diseases. The findings underscore the importance of adopting healthy lifestyle habits for the prevention and management of breast diseases.

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Section: Discussionsupporting

confidence: 82%

The Relationship between Modifiable Lifestyle Factors and Breast Diseases: A Mendelian Randomization Study

Yang,

Wang,

Han

et al. 2024

Preprint

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“…Considering that age is a substantial risk factor for endometrial cancer, therefore, SNP rs7128029 G>A could synergize with age to exacerbate the increased risk of endometrial cancer [ 28 ]. In addition, unhealthy lifestyle presents another risk factors for increasing the predisposition to endometrial cancer [ 29 ]. Consistently, we found that the rs7128029 G>A-endometrial cancer association was more pronounced in the population who are smoker.…”

Section: Discussionmentioning

confidence: 99%

Alternative splicing of PSMD13 mediated by genetic variants is significantly associated with endometrial cancer risk

Cao

Mao

et al. 2023

J Gynecol Oncol

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Objective Accumulating evidence has shown that aberrant alternative splicing events are closely associated with the onset and development of cancer. However, whether genetic variants-associated alternative splicing is linked to risk of endometrial cancer remains largely uncertain. Methods We identified single nucleotide polymorphisms (SNPs) locates in the splicing number trait locus (sQTL) of endometrial cancer using the CancerSplicing QTL database. In parallel with bioinformatics analysis, we conducted a case-control study comprising 2,000 cases and 2,013 controls to assess the association between identified SNP which possesses mRNA splicing function and endometrial cancer susceptibility. Furthermore, we used the Kaplan-Meier Plotter, The Human Protein Atlas, SPNR, and Spliceman2 databases for sQTL and differential gene expression analyses to identify the genetic variant which most potentially influence the risk of endometrial cancer through alternative splicing to reveal the potential mechanism by which candidate SNPs regulate the risk of endometrial cancer. Results The results indicated that SNP rs7128029 A

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“…6 Concerning the modifiable cancer risk factors shown in the present study, blood estrogen levels can be elevated in postmenopausal women with obesity 7 and in pre-and postmenopausal women with drinking habits, 8,9 but cannot be elevated in women with smoking habits. 10 The age-specific incidence and mortality rates of uterine body cancer, another estrogen-related cancer, also increased from 2005 to 2015, despite smaller rates compared with those of breast cancer. The age-specific incidence rate of uterine body cancer increased in a bell-shaped pattern, which was, interestingly, almost the same as that of breast cancer in 1980.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations of increasing breast cancer incidence with the current drinking habits and the past smoking habits among Japanese women

Aoki

Niitsu

Baba

et al. 2023

Proceedings of Singapore Healthcare

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Background We have reported that age-specific incidence rates of breast cancer among Japanese women increased from 2005 to 2015 in a bimodal distribution pattern, with two peaks in the pre- and postmenopausal age groups. Objectives The present study aimed to assess the associations of the increasing age-specific breast cancer incidence or mortality with the prevalence of obesity and drinking and smoking habits, compared with those in uterine body, female and male colon and lung cancers. Methods Linear correlations of annual rates from 2005 to 2015 of the 10-year age-specific cancer incidence and mortality with the prevalence of obesity (body mass index, 25 and over) and drinking (alcohol, 20 g and over 3 times or more a week) and smoking habits were assessed by Pearson’s correlation coefficients during the same 10-year period (from 2005 to 2015) or the 10-year period 10 years before the cancer incidence and mortality were noted (from 1995 to 2005). Results Positive correlations (r>0.640) were found between the increasing breast cancer incidence and the drinking habit during the same period or the smoking habit during the period 10 years before. Similar but weaker correlations were found for the breast cancer mortality rate increasing with age. Positive correlations were found between the decreasing male lung cancer mortality rate and the smoking habit rate during the period 10 years before. Conclusions The present ecological study indicated that the breast cancer incidence was associated with the current drinking habits and the past smoking habits among Japanese women.

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Cigarette Smoking and Estrogen-Related Cancer

Cited by 21 publications

References 184 publications

The Relationship between Modifiable Lifestyle Factors and Breast Diseases: A Mendelian Randomization Study

The Relationship between Modifiable Lifestyle Factors and Breast Diseases: A Mendelian Randomization Study

Alternative splicing of PSMD13 mediated by genetic variants is significantly associated with endometrial cancer risk

Associations of increasing breast cancer incidence with the current drinking habits and the past smoking habits among Japanese women

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