Cigarette smoking and mammographic breast density among Polish women

Pepłońska, Beata; Kałużny, Paweł

doi:10.13075/ijomeh.1896.01832

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…Other studies have found a significant correlation between smoking and breast density. 38,39 In contrast to our study, other studies have found a significant relationship between higher parity and a decrease in breast density. It appears that low parity is associated with young age and increased breast density, likely due to hormonal changes in the body after pregnancy, and this leads to changes in breast density.…”

Section: Discussioncontrasting

confidence: 99%

The Relationship Between Breast Cancer Risk Factors and Mammographic Density

Ranjkesh,

Shaker,

Mehrtabar

et al. 2024

Int J Drug Res Clin

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Background: Mammography is the most important evaluation technique for breast cancer screening. The importance of understanding mammographic density becomes evident when considering its relationship with breast cancer risk. There exists a positive correlation between high mammographic density and an increased susceptibility to breast cancer. Therefore, knowing the prevalence of breast density and its associated factors helps consider possible interventions and medical management to alter the density and properly follow up with the patients. Methods: A total of 350 women in Azerbaijan enrolled in this cross-sectional study. Patient’s questionnaires included demographic data such as age, weight, height, education, menarche age, menopause status and age, oophorectomy history, marital status, number of successful deliveries, age of first delivery, number of breast-feeding times, duration of breastfeeding, oral contraceptives/ hormone replacement therapy (HRT) usage, menstrual status, familial history of cancer, history of benign breast lesion biopsy, and alcohol/smoking status. The evaluation of breast density was done according to the American College of Radiology grading A to D. Results: The average age of the studied patients was 45.68±6.96 years with a median of 44.5 years. The population of women with breast density above 50% was higher compared to those with low breast density (51.4% versus 48.6%). In women without a history of breastfeeding, the frequency of breast density above 50% was observed in 76.4% of women. Significantly, lower densities were observed during menopause, and higher densities were observed during nonmenopause (P=0.001). Furthermore, no relationship was observed between breast composition and nulliparity, history of oophorectomy, duration of breastfeeding, marital status, menstrual status, and oral contraceptive pill (OCP) consumption. Conclusion: The main risk factors of high breast density include young age, menstrual status (non-menopausal patients), lack of breastfeeding after childbirth, older age of first delivery, and lower body mass index

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Section: Discussioncontrasting

confidence: 99%

The Relationship Between Breast Cancer Risk Factors and Mammographic Density

Ranjkesh,

Shaker,

Mehrtabar

et al. 2024

Int J Drug Res Clin

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“…Several studies have been conducted to investigate the dominant effect of cigarrete smoking on MBD. A cross sectional study by BEATA PEPŁOŃSKA and PAWEŁ KAŁUŻNY (21) found out that former smokers had a signi cantly lower volumetric mammographic density compared to the non-smokers in the crude analysis (p = 0.022). The analyses adjusted for important confounders revealed an inverse statistically signi cant association between the number of pack-years and volumetric mammographic density among the current smokers (p = 0.048).…”

Section: Discussionmentioning

confidence: 99%

Association between Mammographic Breast Density, Breast Cancer and Its Common Risk Factors Among Women: A Case-Control Study

Amini¹,

Rattani

Hofiani³

et al. 2023

Preprint

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Purpose To identify the association of mammographic breast density with breast cancer and its common risk factors in the context of Afghanistan. Methods A case-control study enrolled Afghan women, age 35-years and above who were referred to the Radiology Department of French Medical Institute for Mothers and Children. Of all participants (n = 270), 71 had pathology proven breast malignancy labelled as cases and rest with normal/abnormal mammogram but negative pathology report for malignancy were labelled as controls. Results MBD type b, c and d had greater likelihood to be diagnosed with breast cancer compared to MBD type a and this difference was statistically significant, P = 0.025. The Odds Ratio of 10.057 suggests that participants with MBD type b, c, and d were 10.057 times more likely to have a breast cancer diagnosis compared to MBD type a with 95% CI of (1.337–75.660). The association between MBD and age, parity, breast-feeding history, breast feeding number, menopausal status, passive smoking, and BMI were statistically significant with the p value less than 0.05, whereas no statistically significant association was found between MBD and family history of breast cancer, active smoking, physical activity, OCP and HRT usage. Conclusion Afghan women with higher types of MBD (b, c and d) are 10 times more likely to be diagnosed with breast cancer compared to Afghan women with type a MBD.

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“…published a cross-sectional study on cigarette smoking and MBD in a series of 467 Polish women aged 40–60 years (79% menopausal) who underwent screening mammography in 2013–2018. The adjusted analyses showed an inverse significant association between the number of pack-years and volumetric MBD among the current smokers ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort

Bendinelli,

Caini,

Assedi

et al. 2024

Front. Oncol.

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IntroductionCigarette smoking has been recognized as a risk factor for breast cancer (BC) also if the biological mechanism remains poorly understood. High mammographic breast density (MBD) is associated with BC risk and many BC risk factors, such as genetic, anthropometric, reproductive and lifestyle factors and age, are also able to modulate MBD. The aim of the present study was to prospectively explore, in post-menopausal women, the association between smoking habits and MBD, assessed using an automated software, considering duration and intensity of smoking.MethodsThe analysis was carried out in 3,774 women enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) Florence cohort in 1993-98, participating in the 2004-06 follow up (FU) and with at least one full-field digital mammography (FFDM) performed after FU. For each woman, detailed information on smoking habits, anthropometry, lifestyle and reproductive history was collected at enrollment and at FU. Smoking information at baseline and at FU was integrated. The fully automated Volpara™ software was used to obtain total breast volume (cm3), absolute breast dense volume (DV, cm3) and volumetric percent density (VPD, %) from the first available FFDM (average 5.3 years from FU). Multivariable linear regression models were applied to evaluate the associations between smoking habits and VPD or DV.ResultsAn inverse association between smoking exposure and VPD emerged (Diff% -7.96%, p <0.0001 for current smokers and -3.92%, p 0.01 for former smokers, compared with non-smokers). An inverse dose-response relationship with number of cigarettes/day, years of smoking duration and lifetime smoking exposure (pack-years) and a direct association with time since smoking cessation among former smokers emerged. Similar associations, with an attenuated effect, emerged when DV was considered as the outcome variable.DiscussionThis longitudinal study confirms the inverse association between active smoking, a known risk factor for BC, and MBD among post-menopausal women. The inclusion of smoking habits in the existing BC risk prediction models could be evaluated in future studies.

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Cigarette smoking and mammographic breast density among Polish women

Cited by 5 publications

References 26 publications

The Relationship Between Breast Cancer Risk Factors and Mammographic Density

The Relationship Between Breast Cancer Risk Factors and Mammographic Density

Association between Mammographic Breast Density, Breast Cancer and Its Common Risk Factors Among Women: A Case-Control Study

Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort

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