Cigarette smoking and steroid hormones in women

Key, Timothy J.; Pike, Malcolm C.; Baron, John A.; Moore, John W.; Wang, Dennis Y.; Thomas, B.S.; Bulbrook, R. D.

doi:10.1016/0960-0760(91)90247-3

Cited by 61 publications

(37 citation statements)

References 24 publications

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“…The decrease that has previously been reported in progesterone levels after long-term storage at (708C was suggested to be related with molecular modification or by interference of the cryotube material used in low temperature storage [1]. On the other hand, apparently normal progesterone levels in sera stored at (208C for up to 7 years have been reported [12]. However, comparing storage at (208C with storage at (708C may not be acceptable for the sex steroid hormones [11,13].…”

Section: Discussionmentioning

confidence: 81%

“…Several authors have reported either stability [1,7,8] or some degradation over time [9Á11] of estradiol and/or testosterone levels in serum samples stored at the very low or low ((20 o C) temperature. On the other hand, one study reported apparently normal progesterone levels in sera stored at (208C for up to 7 years [12], while in another study progesterone levels decreased up to 40% over 3 years of cryopreservation at (80 8 C [1]. The Finnish Maternity Cohort (FMC) [4] is to the best of our knowledge the world's largest serum bank with 1 470 000 samples from 750 000 pregnant women.…”

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confidence: 99%

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Effect of long-term storage on hormone measurements in samples from pregnant women: The experience of the Finnish Maternity Cohort

Holl¹,

Lundin

Kaasila³

et al. 2008

Acta Oncologica

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Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

Effect of long-term storage on hormone measurements in samples from pregnant women: The experience of the Finnish Maternity Cohort

Holl¹,

Lundin

Kaasila³

et al. 2008

Acta Oncologica

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“…In the same way, other authors (14,16) found a negative correlation between DHEAS level and cardiovascular morbidity. Tobacco consumption may have a direct effect on DHEAS level, even if results are controversial: several authors found a higher level of DHEAS in smokers (15,16,(38)(39)(40), whereas others did not (41,42), or even found the opposite (22,43). Another explanation for the interaction is that a low DHEAS level in men could be an indicator and͞or a potentiator of cardiovascular disease related to smoking habits, or reciprocally that a low DHEAS level could lead to cardiovascular dysfunction that would be worsened by tobacco consumption.…”

Section: Discussionmentioning

confidence: 99%

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality

Mazat

Lafont

Berr

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

149

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The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agé es) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in women, a decrease with age and, among men, a negative correlation between the DHEAS level and mortality at 2 and 4 years. Here, with an 8-year followup in 290 subjects, we show a global decrease of 2.3% per year for men and 3.9% per year for women. However, in approximately 30% of cases, there was an increase of DHEAS. We observed no relationship between the evolution of DHEAS level and functional, psychological, and mental status, possibly because of selection by death. In women, no association was found between mortality and DHEAS level. In men, the relative risk (RR) of death was higher for the lowest levels of DHEAS (RR ‫؍‬ 1.9, P ‫؍‬ 0.007), with RR ‫؍‬ 6.5, P ‫؍‬ 0.003 for those under 70 years old, a result indicating heterogeneity of the population. There was an effect of subjective health on mortality that disappeared after adjustment of DHEAS levels, suggesting its relation with these DHEAS levels. Death RR was much higher in smokers with a low DHEAS level than in nonsmokers with high DHEAS (RR ‫؍‬ 6.7, P ‫؍‬ 0.001). We submit that the involvement of DHEAS is possibly different according to gender, that association between low DHEAS level and mortality only for men under 70 years old possibly reflects heterogeneity of the population, and that DHEAS level is a reliable predictor of death in male smokers. I n human beings, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are secreted adrenal steroids whose role is still poorly understood. Except in the nervous system, no receptor for those steroids has been described, and they likely operate in part by a transformation into androgens and estrogens (1-5) and probably also directly as neuroactive steroids (6). Furthermore, DHEAS concentration declines with age (7, 8) and remains 10-20% higher in men than in women (9), despite an important interindividual range.The decline of DHEAS concentrations with aging has led to the suggestion that DHEAS could play a role in itself and be implicated in longevity. Thus, DHEAS has been studied with controversial results in several processes that occur during aging (10, 11). In particular with reference to the mortality issue studied in this paper, we note that DHEAS has been inversely related to cardiovascular diseases in men (12-16), but this relation was not found in women (17).To clarify the role of DHEAS, our strategy within the PAQUID ʈ program (a prospective cohort study of elderly subjects from the southwest of France) was to relate DHEAS level with several health parameters and mortality. Among the 3,777 elderly subjects of this cohort, 622 volunteers agreed to have blood sampling after 1 year of followup. The measurement of DHEAS concentrations at this time allowed us to confirm the already known ...

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“…At least five earlier investigations have examined the association of tobacco smoking with blood levels of DHEA and/or DHEA-sulfate [3,13,14,17,48]. In none has an inverse association been found and in two of them significant positive associations with at least one of these compounds were documented [14,17].…”

Section: Discussionmentioning

confidence: 99%

Dehydroepiandrosterone Relations to Dietary and Lifestyle Variables in a General Population Sample

Trichopoulou¹,

Bamia²,

Kalapothaki³

et al. 2003

Ann Nutr Metab

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Background/Aims: Dehydroepiandrosterone (DHEA) is generally considered to have beneficial effects in humans. There is, however, limited information concerning the role of lifestyle variables, including diet, on blood DHEA levels. We have undertaken a study of DHEA determinants in a general population sample of adult Greeks. Methods: The sample consisted of 620 apparently healthy men and women aged 35–65 years, from all over Greece, participating in the EPIC study. Plasma DHEA was determined by radioimmunoassay. Nutritional intakes were ascertained through an interviewer-administered validated food frequency questionnaire, which also contained information on lifestyle variables. Statistical analyses were undertaken through simple cross-tabulations and by modelling the data through multiple regression. Results: DHEA declines sharply with age and there is some evidence that the decline may be sharper in men than in women. Protein intake was significantly inversely associated with plasma levels of DHEA, whereas other dietary factors, energy expenditure and anthropometric variables were unrelated to this hormone. Alcohol intake and tobacco smoking tended to be positively related to DHEA, but the respective associations were not statistically significant. Conclusion: There has been a growing interest in replacement of DHEA in ageing adults. If confirmed, our results would indicate that a reduction in protein intake could have qualitatively similar effects.

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Cigarette smoking and steroid hormones in women

Cited by 61 publications

References 24 publications

Effect of long-term storage on hormone measurements in samples from pregnant women: The experience of the Finnish Maternity Cohort

Effect of long-term storage on hormone measurements in samples from pregnant women: The experience of the Finnish Maternity Cohort

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality

Dehydroepiandrosterone Relations to Dietary and Lifestyle Variables in a General Population Sample

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