Cigarette smoking and the risk of Barrett’s esophagus

Kubo, Ai; Levin, Theodore R.; Block, Gladys; Rumore, Gregory J.; Quesenberry, Charles P.; Buffler, Patricia A.; Corley, Douglas A.

doi:10.1007/s10552-008-9244-4

Cited by 49 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This difference in strength of the associations with BE and esophageal adenocarcinoma is consistent with the literature (e.g., refs. 9,12,16,42,43). This observation may indicate that smoking plays a role in the later stages of esophageal carcinogenesis: in the progression of BE to esophageal …”

Section: Cigarette Smokingmentioning

confidence: 89%

“…Two casecontrol studies have found comparable results (12,16). One possible explanation is that former smokers have more health-seeking behavior and may therefore be more likely to be diagnosed with BE.…”

Section: Cigarette Smokingmentioning

confidence: 94%

“…The relationship between cigarette smoking and risk of BE has been studied in some case-control studies (10,12,15,16), whereas no cohort studies have reported on this relationship. Some observed a positive association (10,12), whereas other studies did not observe an association (9,16). Alcohol consumption, and its possible relationship with BE, has been studied in a few case-control studies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Prospective Cohort Study on Overweight, Smoking, Alcohol Consumption, and Risk of Barrett's Esophagus

Steevens

Schouten

Driessen

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Barrett's esophagus (BE) is a precursor lesion of esophageal adenocarcinoma. Besides gastroesophageal reflux, possible risk factors for BE include overweight, cigarette smoking, and alcohol consumption. Our objective was to study these associations by using prospective data.Methods: The prospective Netherlands Cohort Study, initiated in 1986, consists of 120,852 men and women, aged 55 to 69 years at baseline. At baseline, all subjects completed a questionnaire on dietary habits and lifestyle. After 16.3 years of follow-up, 370 BE cases with specialized intestinal metaplasia and 3,866 subcohort members were available for case-cohort analysis. Cox proportional hazards models were used to calculate incidence rate ratios (RR) and 95% CIs.Results

show abstract

Section: Cigarette Smokingmentioning

confidence: 89%

Section: Cigarette Smokingmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Prospective Cohort Study on Overweight, Smoking, Alcohol Consumption, and Risk of Barrett's Esophagus

Steevens

Schouten

Driessen

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…By relaxing the lower esophageal sphincter and interfering with esophageal peristalsis, calcium antagonists and other muscle-relaxing agents promote acid reflux. Although all these relationships may be influential in individual patients, the overall epidemiologic relevance of dietary patterns, social habits, and drug consumption seems relatively small [35,36,37]. They do not to account for the general geographic or temporal patterns of GERD, as well as its various grades of severity among individual patients.…”

Section: Associations With Food Drugs and Social Habitsmentioning

confidence: 99%

Effects of Environment and Lifestyle on Gastroesophageal Reflux Disease

Sonnenberg¹

2011

Dig Dis

View full text Add to dashboard Cite

Background: Gastroesophageal reflux disease (GERD) is comprised of a spectrum of related disorders, including hiatal hernia, reflux disease with its associated symptoms, erosive esophagitis, peptic stricture, Barrett’s esophagus, and esophageal adenocarcinoma. Besides multiple pathophysiological associations among these disorders, they are also characterized by their comorbid occurrence in identical patients and by their similar epidemiologic behavior. The occurrence of GERD is shaped by marked temporal and geographic variations, suggesting the influence of environmental risk factors in the etiology of these diseases. Variations by Time, Geography, and Race: Between 1975 and 2005, the incidence of GERD and esophageal adenocarcinoma increased fivefold in most Western countries. The incidence of GERD also appears to be rising in the most developed countries of Asia. All severe forms of GERD, such as erosive esophagitis, peptic stricture, Barrett’s metaplasia, and esophageal adenocarcinoma, are more common among whites than other ethnic groups. Affluence and Obesity as Risk Factors: Barrett’s esophagus and esophageal adenocarcinoma tend to occur slightly more often in subjects with higher income. Overweight and obesity contribute to the development of hiatal hernia, increase intra-abdominal pressure, and promote gastroesophageal reflux. Weight gain increases reflux symptoms, whereas weight loss decreases such symptoms. Other risk factors, such as smoking, alcohol, dietary fat, or drugs, play only a minor role in shaping the epidemiologic patterns of GERD. Protection through Helicobacter pylori: On a population level, a high prevalence of H. pylori infection is likely to reduce levels of acid secretion and protect some carriers of the infection against reflux disease and its associated complications. Several studies have confirmed a lesser prevalence of H. pylori among subjects with than without GERD. Until recently, populations in Africa and Asia may have been protected against the development of GERD and esophageal adenocarcinoma by their higher prevalence of H. pylori infection. Conclusion: The study of environmental risk factors may provide an opportunity to better understand GERD and develop a means of its prevention.

show abstract

“…Studies on the pathogenetic role of tobacco (45) and alcohol yield conflictive results, and an association with BE is only found in some of them (46,47). Vegetable-and fruit-rich diets have been associated with a lower BE risk attributed to high antioxidant levels (48).…”

Section: Pathophysiology and Risk Factorsmentioning

confidence: 99%