Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

Abdel‐Rahman, Omar; Helbling, Daniel; Schöb, O.; Eltobgy, Mostafa; Mohamed, Hadeer; Schmidt, Jan; Giryes, Anwar; Mehrabi, Arianeb; Iype, Satheesh; John, Hannah; Tekbaş, Aysun; Zidan, Ahmed; Oweira, Hani

doi:10.1111/jebm.12270

Cited by 90 publications

(78 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We explored the data and found that 19.3% of patients with tobacco use disorder also had drug use disorder compared with 2.2% patients without tobacco use disorder. The co-existing tobacco use and chronic hepatitis may positively interact and increase the risk of developing liver cancer and premature death (Abdel‐Rahman et al, 2017; Chuang et al, 2010; Pang et al, 2015). Thus, tobacco cessation interventions should also assess and treat comorbid drug use disorders and drug use related hepatitis (Marshall et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data

Zhu

Ghitza

2018

Drug and Alcohol Dependence

118

View full text Add to dashboard Cite

Background: Chronic diseases are prevalent and the leading causes of mortality. Comorbidity of substance use disorders (SUDs) and chronic diseases is understudied to inform behavioral healthcare integration. Objectives: This study leveraged electronic health record (EHR) data of 211,880 adults from a large health system to examine prevalence and correlates of comorbidity of SUDs and nine chronic disease groups and to determine their association with hospitalization. Methods: Logistic regression analyses were conducted to estimate associations between chronic diseases and SUDs. To control for severity of diagnosis, analyses of associations between SUD and hospitalization were stratified by the number of chronic conditions. Results: In the sample, 48.3% had ≥1 chronic condition (hypertension 33.7%, arthritis 16.2%, diabetes 13.7%, chronic kidney disease 9.9%, asthma 9.1%, chronic obstructive pulmonary disease 8.9%, ischemic heart disease 8.3%, cancer 4.6%, and hepatitis 1.3%). Prevalence of SUD (overall 13.3%) among patients increased with multiple chronic conditions (14.3% having SUD among patients with one condition; 21.2% having SUD among patients with two to three conditions; and 32.5% having SUD among patients with 4–9 conditions). Chronic conditions were associated with increased odds of SUDs. For all SUD groups, hospitalization was more prevalent among patients with SUD than those without it; prevalence of hospitalization increased with the number of comorbid chronic conditions. Conclusions: Findings reveal a striking pattern of multicomorbidity of SUD and chronic diseases and its positive association with hospitalization. Behavioral healthcare integration should consider efforts to assess and treat comorbid SUD and chronic diseases, especially among adults with multiple chronic conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data

Zhu

Ghitza

2018

Drug and Alcohol Dependence

118

View full text Add to dashboard Cite

show abstract

“…In general, the tobacco ingredients are metabolized in liver and their carcinogenic effect is well-documented. Recently, a systematic review of 81 epidemiological studies [35] showed that there is an increase in the incidence of HCC risk and mortality among cigarette smokers. In Egypt, conflicting results were found regarding the association between tobacco smoking and the overall risk of HCC [5,30,31].…”

Section: (C) Smokingmentioning

confidence: 99%

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Rashed

Kandeil

Mahmoud

et al. 2020

J Egypt Natl Canc Inst

208

163

View full text Add to dashboard Cite

Background: Worldwide, hepatocellular carcinoma (HCC) is a universal problem and its epidemiological data showed variation from place to place. Hepatocellular carcinoma (HCC) is the sixth and fourth common cancer in worldwide and Egypt, respectively. Egypt ranks the third and 15 th most populous country in Africa and worldwide, respectively. The aim of this review is to compare the status of HCC in Egypt to that in the worldwide from different issues; risk factors, screening and surveillance, diagnosis and treatment, prevention, as well as research strategy. Main body: The risk factors for HCC in Egypt are of great importance to be reported. The risk factor for HCC are either environmental-or host/genetic-related risk factors. In the last years, there is a tangible improvement of both screening and surveillance strategies of HCC in Egypt. The unprecedented national screening campaign launched by the end of 2018 is a mirror image of this improvement. While the improvement of the HCC prevention requires the governmental health administration to implement health policies. Although the diagnosis of Egyptian HCC patients follows the international guidelines but HCC treatment options are limited in terms of cost. In addition, there are limited Egyptian reports about HCC survival and relapse. Both basic and clinical HCC research in Egypt are still limited compared to worldwide. Short conclusion: Deep analysis and understanding of factors affecting HCC burden variation worldwide help in customization of efforts exerted to face HCC in different countries especially large country like Egypt. Overall, the presence of a research strategy to fight HCC in Egyptian patients will help in the optimum allocation of available resources to reduce the numbers of HCC cases and deaths and to improve the quality of life.

show abstract

“…The highest liver cancer rates are found in East and Southeast Asia and in Middle and Western Africa. This difference in incidence of liver cancer between different geographical regions and countries is mainly attributed to difference in the incidence of underlying risk factors . A substantial amount of patients are diagnosed at a later stage of the disease, which may preclude curative treatment options.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics analysis of 1180 patients with hepatocellular carcinoma secondary to hepatitis B, hepatitis C and alcoholic liver disease

Zhao

Zhu

Han

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Objective To determine the clinical and liver stiffness characteristics of a cohort of Chinese patients with Hepatocellular carcinoma in different stages of Barcelona clinic liver cancer. Methods Details of 1180 patients with Hepatocellular carcinoma referred from October 2014 to November 2017 were collected retrospectively. Demographic data, etiology, clinical, and biochemical details were retrospectively analyzed. The changes of liver stiffness in different etiologies and different stages of Barcelona clinic liver cancer were especially analyzed. Results The onset age was 60.33 ± 9.11 (range 24‐84) years, 9 cases were ≤40 years, 572 cases were 41‐60 years, males accounted for 83.92%, females accounted for 16.08%; 599 cases were ≥61 years, males accounted for 78.25%, females accounted for 21.75%. Compared with males, the proportion of females ≥61 is higher than that of men. Majority (n = 787; 66.69%) had HBV infection; second commonest cause was HCV infection (n = 217; 18.39%). More patients with HBV infection were 41‐60 years (69.06%) and were younger than HCV patients. There was no statistical difference in etiology, age, gender, and distribution of diabetes mellitus among different Barcelona clinic liver cancer stages (P > .05). The overall Hepatocellular carcinoma (HCC) was found to be positively correlated with alkaline phosphatase, γ‐glutamyltransferase, and alpha‐fetoprotein and liver stiffness measurement values from stage A to stage D (P < .05). ANOVA analysis showed that the overall liver stiffness measurement among the four BCLC stages was found to be statistically significant different in HBV‐infected and HCV‐infected HCC patients. Conclusion Majority (99.24%) were patients aged >40 years old. Male is a high incidence population. In etiological analysis, HBV dominates HCC occurrence, HBV‐, HCV‐, and alcohol‐associated HCC have distinct clinical and biochemical characteristics, necessitating different screening policies to optimize HCC surveillance and management.

show abstract

Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

Abstract: Cigarette smoking increases the incidence and mortality of HCC. Further studies are needed to evaluate possible impact of quitting smoking on decreasing this risk.

Cited by 90 publications

References 100 publications

Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data

Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Clinical characteristics analysis of 1180 patients with hepatocellular carcinoma secondary to hepatitis B, hepatitis C and alcoholic liver disease

Contact Info

Product

Resources

About