Cigarette smoking during pregnancy and hyperactive-distractible preschooler's: A follow-up study

Linnet, Karen Markussen; Obel, Carsten; Bonde, Else; Thomsen, Per Hove; Secher, Niels Jørgen; Wisborg, Kirsten; Henriksen, Tine Brink

doi:10.1080/08035250500459709

Cited by 30 publications

(4 citation statements)

References 29 publications

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“…For instance, Linnet et al reported that smoking in pregnancy increased the prevalence of hyperkinetic disorder by threefold [ 7 ]. Another study [ 8 ] investigated 3.5-year-old preschool children and observed that when compared with children of non-smokers, children born to mothers who smoked 10 or more cigarettes per day had a 60% increased risk of hyperactivity and distractibility. Based on a large, nationally representative sample of children aged 4–11 years, Weitzman et al [ 9 ] suggested an independent relationship between maternal smoking both during and after pregnancy and the increased rates of behavioral problems in children, and their further evidence indicated a dose-response relationship.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Environmental Tobacco Smoke and Hyperactivity Behavior in Chinese Young Children

Lin

Hou

Yin³

et al. 2017

IJERPH

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This study aimed to examine the association between prenatal environmental tobacco smoke (ETS) exposure and hyperactivity behaviors in young children. A cross-sectional study was undertaken among 21,243 participants from all of the kindergartens in Longhua District of Shenzhen, China. Multivariate logistic regression models and hierarchical linear models were employed to assess the associations. After adjusting for potential confounders of gender, preterm birth, birth asphyxiation, etc., prenatal ETS exposure was significantly associated with an increased risk of hyperactivity behaviors in young children (OR (95% CI) = 1.51 (1.28–1.77); β (95% CI) = 0.017 (0.013–0.020)). Along with increases in children’s prenatal ETS exposure dose (measured by daily ETS exposure duration, daily cigarette consumption by household members, and overall score of prenatal ETS exposure), the children were also increasingly more likely to exhibit hyperactivity behaviors. Furthermore, children whose mothers had prenatal ETS exposure in any one or more of the pregnancy trimesters were more likely to exhibit hyperactivity behaviors as compared with those born to non-exposure mothers (all p < 0.05). Overall, prenatal ETS exposure could be associated with a detrimental impact on offspring’s hyperactivity behaviors, and public health efforts are needed to reduce prenatal ETS exposure.

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Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Environmental Tobacco Smoke and Hyperactivity Behavior in Chinese Young Children

Lin

Hou

Yin³

et al. 2017

IJERPH

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“…An increased risk for intrauterine growth retardation, sudden infant death syndrome, and asthma are well-known adverse effects of in utero tobacco exposure (Higgins 2002). In addition, effects of in utero tobacco exposure on behavioral problems have been reported in various experimental and epidemiologic studies (Ernst et al 2001; Eskenazi and Castorina 1999; Wakschlag et al 2002; Weitzman et al 2002) including some longitudinal studies (Markussen Linnet et al 2006; Wakschlag et al 1997). Prospective studies that systematically assess a broad range of behavioral problems outcomes are sparse.…”

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confidence: 99%

Prenatal and Postnatal Tobacco Exposure and Behavioral Problems in 10-Year-Old Children: Results from the GINI-plus Prospective Birth Cohort Study

Rückinger

Rzehak

Chen

et al. 2010

Environ Health Perspect

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BackgroundPrenatal and postnatal tobacco exposure have been reported to be associated with behavioral problems. However, the magnitude of the association with tobacco exposure at specific periods of exposure is unclear.ObjectiveWe assessed the relative risk of behavioral problems in children who had been exposed to tobacco smoke in utero and postnatally.MethodsWe analyzed data from a prospective birth cohort study in two cities in Germany: the German Infant Nutrition Intervention. Our sample included 5,991 children born between 1995 and 1998 as well as their parents. We measured behavioral problems using the Strength and Difficulties Questionnaire (SDQ) at follow-up 10 years after birth. According to prespecified SDQ cutoff values, children were classified as “normal,” “borderline,” or “abnormal” according to the subscales “emotional symptoms,” “conduct problems,” “hyperactivity/inattention,” “peer-relationship problems,” and a total difficulties score. Smoke exposure and further covariates were assessed using parent questionnaires.ResultsCompared with children not exposed to tobacco smoke, children exposed both pre- and postnatally to tobacco smoke had twice the estimated risk [95% confidence interval (CI), 1.4–3.1] of being classified as abnormal according to the total difficulties score of the SDQ at 10 years of age. Children who were only prenatally exposed had a 90% higher relative risk (95% CI, 0.9–4.0), whereas children who were only postnatally exposed had a 30% higher relative risk (95% CI, 0.9–1.9). These results could not be explained by confounding by parental education, father’s employment, child’s time spent in front of computer or television screen, being a single father or mother, or mother’s age.ConclusionsPrenatal exposure to tobacco smoke is associated with behavioral problems in school-age children. Although our findings do not preclude the influence of postnatal exposure, prenatal exposure seems to be more important.

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“…A number of studies have also demonstrated associations between adverse birth outcomes, such as size at birth adjusted for gestational age, and behavioral problems, including hyperactivity/inattention and total behavioral difficulties ( 17 – 19 ). A separate, but closely related literature has examined the associations between prenatal stress and developmental outcomes of exposed children, and has identified relatively consistent links between various types of maternal stress and child hyperactivity, conduct and peer problems, and behavioral difficulties ( 20 – 25 ).…”

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confidence: 99%

Overall and Sex-Specific Associations Between Fetal Adversity and Child Development at Age 1 Year: Evidence From Brazil

Fink

Andrews

Brentani

et al. 2018

American Journal of Epidemiology

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A growing body of epigenetic research suggests that in-utero adaptations to environmental changes display important sex-specific variation. We tested this heterogeneous adaptation hypothesis using data from 900 children born at the University Hospital in São Paulo, Brazil, between October 2013 and April 2014. Crude and adjusting linear models were used to quantify the associations between prematurity, being small for gestational age, and children’s physical and mental development at 12 months of age. Prematurity was negatively associated with neuropsychological development in final models (z score difference, −0.42, 95% confidence intervals: −0.71, −0.14), but associations did not vary significantly by sex. For being small for gestational age, associations with height-for-age, weight-for-age, and neuropsychological development were also negative, but they were systematically larger for male than for female infants (P < 0.05 for all). These results suggest that male fetuses may be more vulnerable to intrauterine adversity than female fetuses. Further research will be needed to better understand the mechanisms underlying these sex-specific associations.

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Cigarette smoking during pregnancy and hyperactive-distractible preschooler's: A follow-up study

Abstract: Exposure to tobacco smoke in utero was associated with hyperactive-distractible behaviour in preschool children.

Cited by 30 publications

References 29 publications

Prenatal Exposure to Environmental Tobacco Smoke and Hyperactivity Behavior in Chinese Young Children

Prenatal Exposure to Environmental Tobacco Smoke and Hyperactivity Behavior in Chinese Young Children

Prenatal and Postnatal Tobacco Exposure and Behavioral Problems in 10-Year-Old Children: Results from the GINI-plus Prospective Birth Cohort Study

Overall and Sex-Specific Associations Between Fetal Adversity and Child Development at Age 1 Year: Evidence From Brazil

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