Cigarette Smoking Is Associated with Conversion from Normoglycemia to Impaired Fasting Glucose: The Western New York Health Study

Abstract

Purpose-To determine whether cigarette smoking is associated with the conversion from normoglycemia to impaired fasting glucose (IFG). (1996)(1997)(1998)(1999)(2000)(2001) were reexamined (68% response rate). Incident IFG was defined as a subject whose baseline fasting plasma glucose was <100 mg/dl (normoglycemic) and between 100 and 125 mg/dl at follow-up. Prevalent IFG (n=528) was excluded.. Baseline smoking status was categorized as never, former or current. Methods-DuringResults-Of the 1,455 participants, 924 were normoglycemic at baseline: 101/924 converted to IFG over six-years. Compared to those who remained normoglycemic, converters to IFG were at baseline older, had a larger BMI, more likely to be hypertensive, currently smoke, and have a family history of T2DM (all P <0.05). Multivariate logistic regression demonstrated that compared to subjects who remained normoglycemic, the OR of incident IFG among former and current smokers (vs. never) was 1.68 (95% confidence interval: 0.99, 2.80) and 2.35 (95% confidence interval: 1.17, 4.72) (P trend =0.008), respectively. Conclusion-Smoking was positively associated with incident IFG after accounting for several putative risk factors.Keywords cigarette smoking; impaired fasting glucose; epidemiology; risk factors Type 2 diabetes mellitus (T2DM) is a formidable public health problem leading to premature morbidity and mortality and contributing to increased health care costs. Putative risk factors associated with the development of T2DM are age, ethnicity, obesity, family history of T2DM, and physical inactivity. Moreover, both the Diabetes Prevention Program and the Finish Correspondence and Reprints to:

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