Cigarette Smoking: Risk Factor for Premature Facial Wrinkling

Kadunce, Donald P.; Burr, Randy; Gress, Richard E.; Kanner, Richard E.; Lyon, Joseph L.; Zone, John J.

doi:10.7326/0003-4819-114-10-840

Cited by 232 publications

(161 citation statements)

References 11 publications

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“…[1][2][3][4][5][6][7] In this study we have shown that severe facial wrinkling (Daniell score >IV) is significantly associated with a lower mean FEV 1 and COPD. Indeed, more than 80% of smokers with facial wrinkling fulfilled the spirometric criteria for COPD.…”

Section: Discussionmentioning

confidence: 92%

“…Individuals were classified as wrinkled using a method similar to that previously described by Kadunce et al 2 The median wrinkle score in our study group was II (IQR 1). For the analysis we classified those individuals in the 90th centile (Daniell score >IV) as wrinkled and those with scores of ,IV as unwrinkled.…”

Section: Discussionmentioning

confidence: 99%

“…Facial wrinkling in smokers may therefore be a biomarker of susceptibility to COPD. C igarette smoking is associated with facial wrinkling [1][2][3][4][5][6][7] that increases with the number of pack years smoked. 2 5 Smoking is also the major risk factor for the development of chronic obstructive pulmonary disease (COPD).…”

mentioning

confidence: 99%

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Smoking related COPD and facial wrinkling: is there a common susceptibility?

Patel

2006

Thorax

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Background: Cigarette smoking causes accelerated facial wrinkling and predisposes to chronic obstructive pulmonary disease (COPD). However, it has long been recognised that there is a subgroup of susceptible smokers who are at increased risk of developing airflow obstruction. We have tested the hypothesis that there is a common susceptibility for the development of COPD and facial wrinkling in cigarette smokers. Methods: One hundred and forty nine current and ex-smokers were recruited from a family based study of COPD genetics, 68 (45.6%) of whom fulfilled the definition of COPD. 124 (83.2%) had no or minor facial wrinkling (Daniell ,IV) and 25 (16.8%) were wrinkled (Daniell score >IV). Generalised estimating equations were used to adjust for familial correlations between related individuals and the potential confounding effects of age and pack years smoked. Results: Forced expiratory volume in 1 second (FEV 1 ) was significantly lower in those with wrinkles than in those without (mean difference in FEV 1 % predicted 213.7%, 95% CI 227.5 to 0.0, p = 0.05) and facial wrinkling was associated with a substantially increased risk of COPD (adjusted OR 5.0, 95% CI 1.3 to 18.5, p,0.02). The Daniell score correlated with the extent of emphysema on the CT scan (p,0.05) and facial wrinkling was also associated with a greater risk of more extensive emphysema (adjusted OR 3.0, 95% CI 1.0 to 9.3, p = 0.05). Conclusion: Facial wrinkling is associated with COPD in smokers, and both disease processes may share a common susceptibility. Facial wrinkling in smokers may therefore be a biomarker of susceptibility to COPD.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Smoking related COPD and facial wrinkling: is there a common susceptibility?

Patel

2006

Thorax

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“…Mechanisms of UVR-induced and accelerated aging are discussed later in this review. The second most important driver of extrinsic aging is cigarette smoking [24][25][26][27][28] .…”

Section: Extrinsic Agingmentioning

confidence: 99%

Introduction to skin aging

Tobin

2017

Journal of Tissue Viability

459

335

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“…Smoking has long been known to affect skin appearance, in particular by promoting facial skin wrinkling (Daniell 1971;Kadunce et al 1991;Koh et al 2002;Patel et al 2006). The effect is enhanced by sunlight (Yin et al 2001), but alterations of elastic tissue properties also occur in sunprotected areas (Frances et al 1991;Helfrich et al 2007).…”

Section: Discussionmentioning

confidence: 99%