Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Masaoka, Hiroyuki; Matsuo, Keitaro; Oze, Isao; Kimura, Takashi; Tamakoshi, Akiko; Sugawara, Yumi; Tsuji, Ichiro; Sawada, Norie; Tsugane, Shoichiro; Ito, Hidemi; Wada, Keiko; Nagata, Chisato; Kitamura, Tetsuhisa; Zha, Ling; Sakata, Ritsu; Ozasa, Kotaro; Lin, Yingsong; Mizoue, Tetsuya; Tanaka, Keitaro; Abe, Sarah Krull; Inoue, Manami

doi:10.2188/jea.je20220085

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Bladder cancer (BC), a prevalent urological malignancy, is a global public health concern, and the 9th commonly diagnosed cancer in men, especially in high-income countries. [ 1 ] Following a report by Boccardo et al, nearly a quarter BC cases are at first diagnosed as muscle-invasive BC. Moreover, <16% of patients, characterized by non-muscle-invasive BC present with invasive recurrent cancer during treatment, in most cases, within 1 year.…”

Section: Introductionmentioning

confidence: 99%

Identifying stage-associated hub genes in bladder cancer via weighted gene co-expression network and robust rank aggregation analyses

Feng

Zhong²,

Jian-hua³

et al. 2022

Medicine

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Background: Bladder cancer (BC) is among the most frequent cancers globally. Although substantial efforts have been put to understand its pathogenesis, its underlying molecular mechanisms have not been fully elucidated. Methods: The robust rank aggregation approach was adopted to integrate 4 eligible bladder urothelial carcinoma microarray datasets from the Gene Expression Omnibus. Differentially expressed gene sets were identified between tumor samples and equivalent healthy samples. We constructed gene co-expression networks using weighted gene co-expression network to explore the alleged relationship between BC clinical characteristics and gene sets, as well as to identify hub genes. We also incorporated the weighted gene co-expression network and robust rank aggregation to screen differentially expressed genes. Results: CDH11, COL6A3, EDNRA, and SERPINF1 were selected from the key module and validated. Based on the results, significant downregulation of the hub genes occurred during the early stages of BC. Moreover, receiver operating characteristics curves and Kaplan–Meier plots showed that the genes exhibited favorable diagnostic and prognostic value for BC. Based on gene set enrichment analysis for single hub gene, all the genes were closely linked to BC cell proliferation. Conclusions: These results offer unique insight into the pathogenesis of BC and recognize CDH11, COL6A3, EDNRA, and SERPINF1 as potential biomarkers with diagnostic and prognostic roles in BC.

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Section: Introductionmentioning

confidence: 99%

Identifying stage-associated hub genes in bladder cancer via weighted gene co-expression network and robust rank aggregation analyses

Feng

Zhong²,

Jian-hua³

et al. 2022

Medicine

View full text Add to dashboard Cite

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Rapid Lifestyle Recommendations to Improve Urologic, Heart and Overall Health

Moyad

2024

Curr Urol Rep

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Addressing urinary incontinence by gender: a nationwide population-based study in Turkiye

Yavuz,

Etiler

2023

BMC Urol

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Background Urinary incontinence (UI), which usually occurs in women but affects both sexes, is a significant public health challenge. This study aims to comprehensively investigate the prevalence and determinants of UI in men and women, considering gender-specific factors. Methods The study performed a secondary analysis on data obtained from 13,383 individuals surveyed in the 2019 Turkish Health Survey, providing a representation of the Turkish population. The dataset included sociodemographic and health-related variables like UI, body mass index (BMI), physical activity, smoking, and chronic diseases—statistical analysis employed chi-square tests and gender-stratified logistic regression models to identify UI-associated factors. Results Our results showed that UI affected 8.8% of the population, with a striking gender disparity. Women had a notably higher prevalence at 11.2%, while men had a lower rate of 5.5%. Importantly, this gender gap narrowed with age. For example, in the 34–44 age group, the female/male ratio was 6.9, but it decreased to 1.4 in the 65–74 age group. Marital status and employment status played significant roles. Separated, divorced, or widowed individuals, particularly women, had the highest prevalence at 19.3%. Employment status influenced UI prevalence, with employed men having the lowest rate (2.1%), while retired women faced the highest rate (15.0%). Higher BMI, especially in obese individuals, significantly raised UI prevalence, reaching 7.9% for men and 15.8% for women. Physical inactivity, notably in women (17.0%), and prolonged sedentary hours (13.9%) were associated with higher UI rates. Former smokers, especially women (15.9%), had a notable impact on UI. Poor perceived health and chronic conditions like Chronic Obstructive Pulmonary Disease (COPD), hypertension, and diabetes were significantly associated with higher UI prevalence. Logistic regression analysis revealed that age, education, perceived health status, COPD, and diabetes were significant factors associated with UI in both sexes, while in women, BMI, physical activity, and smoking also played notable roles. Conclusions This extensive UI study has unveiled notable gender disparities and determinants. Notably, these disparities decrease with age, underlining UI’s changing nature over time. Modifiable factors impact women more, while non-modifiable factors are linked to men. The study underscores the importance of tailoring healthcare strategies to address UI based on gender.

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Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record.

Cited by 4 publications

References 28 publications

Identifying stage-associated hub genes in bladder cancer via weighted gene co-expression network and robust rank aggregation analyses

Identifying stage-associated hub genes in bladder cancer via weighted gene co-expression network and robust rank aggregation analyses

Rapid Lifestyle Recommendations to Improve Urologic, Heart and Overall Health

Addressing urinary incontinence by gender: a nationwide population-based study in Turkiye

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