Ciglitazone Inhibits Oxidized-Low Density Lipoprotein Induced Immune Maturation of Dendritic Cells

Luo, Yun; Liang, Chun; Xu, Congfeng; Jia, Qingzhe; Huang, Dong; Chen, Lianglong; Wang, Keqiang; Wu, Zonggui; Ge, Junbo

doi:10.1097/01.fjc.0000138164.88740.f8

Cited by 29 publications

(21 citation statements)

References 27 publications

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“…Ligand-activated PPARγ decreased the inflammatory response in atherosclerogenic cells (29,30). The previous study from our team also showed that the PPARγ agonist ciglitazone could effectively inhibit ox-LDL-induced DCs maturation (8).…”

Section: Discussionmentioning

confidence: 66%

“…DCs present in normal arteries are immature and become mature during atherogenesis, and emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques was documented (7). Proatherogenic factors such as oxidized low-density lipoproteins (ox-LDL) (8,9), advanced glycation end products (10), and C-reactive protein (CRP) (11) were reported to induce DC maturation and subsequently resulting in T-lymphocyte activation. Therefore, an agent able to inhibit the function of DCs may be beneficial in the treatment of atherosclerotic disease (12).…”

Section: Introductionmentioning

confidence: 99%

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Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway

et al. 2012

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Abstract. Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is effective in the treatment of atherosclerosis (AS)-related diseases. It is widely recognized that AS is a complex inflammatory disease of the arterial wall and the dendritic cells (DCs) is a major player in the pathogenesis of AS via mediating atherosclerotic antigen presenting and T lymphocytes. Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs. Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation. Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) γ agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs. These effects of DHI could be partly reversed by silencing the PPARγ. In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPARγ-mediated signaling pathway.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway

et al. 2012

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“…61 During the last few years, the mechanisms and factors affecting the differentiation and maturation of DCs have been intensely studied in both in vitro and in vivo experimental settings, relevant to atherosclerosis. [128][129][130][131][132][133][134][135][136][137][138] It has been shown that Apolipoprotein A-I, the major protein component of serum high-density lipoproteins, inhibits DC differentiation and maturation. 132 PPAR-a agonists ciglitazone and fenofibrate also inhibit oxLDL-induced maturation and immune functions of DCs in vitro.…”

Section: Tissue Microenvironment In Atherosclerosis and DC Functionmentioning

confidence: 99%

“…132 PPAR-a agonists ciglitazone and fenofibrate also inhibit oxLDL-induced maturation and immune functions of DCs in vitro. 133,134 Advanced glycosylation end products can promote atherosclerosis by inducing maturation of DCs. 135 In advanced atherosclerotic plaques, especially in areas around the lipid cores which lack neovascularization, DC function can be affected by hypoxia.…”

Section: Tissue Microenvironment In Atherosclerosis and DC Functionmentioning

confidence: 99%

Dendritic cells and their role in atherogenesis

Bobryshev

2010

Laboratory Investigation

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Dendritic cells (DCs) are the most potent professional antigen-presenting cells with the unique ability of primary immune response initiation. DCs originate from bone marrow progenitors, which circulate in the peripheral blood and subsequently penetrate peripheral tissues, where they give rise to immature DCs. In peripheral tissues, DCs continuously monitor the microenvironment and, when the cells encounter 'danger' signals, DCs undergo differentiation and maturation. Maturing DCs usually migrate to lymphatic tissues, where they form contacts with T cells to initiate a primary immune response. DCs were identified in arteries in 1995 and since then, further knowledge has been gained about the peculiarities of vascular-associated DCs and their role in atherosclerosis. Immune reactions toward modified lipoproteins and other factors ignited by resident vascular DCs as well as by newly arrived DCs, which originate from blood monocytes, are believed to destabilize arterial homeostasis from very earlier stages of atherogenesis. There is a remarkable heterogeneity of DCs in atherosclerotic lesions. Some DCs mature and become capable of forming clusters with T cells directly within the arterial wall. The predictive value of the numbers of circulating DC precursors in coronary artery disease and in atherosclerosis has been assessed, and it has been shown that DCs have a role in plaque destabilization. Over recent decades, DCs have proven to be a valuable instrument in immunotherapy approaches against cancer and various autoimmune diseases, and this explains the demand that the accumulated knowledge be applied to the field of atherosclerosis immunotherapy.

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“…in 2004, luo et al (47) suggested that the peroxisome proliferator activated receptor (PPar)-γ agonist ciglitazone inhibited the ox-ldl-induced maturation and immune functions of dcs. More recently, Shi et al (48) observed that the PPar-α agonist fenofibrate, which has favorable effects on the development of aTS, also inhibited the ox-ldl-induced immune maturation of dcs.…”

Section: Dendritic Cells As Possible Targets In the Treatment Of Athementioning

confidence: 99%

The functional role of dendritic cells in atherogenesis (Review)

Puddu

Puddu²,

Cravero³

et al. 2010

Mol Med Rep

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Abstract. accumulating evidence suggests that dendritic cells (dcs) play a crucial role in the generation and progression of atherosclerosis (ATS), a lipid-related immuno-inflammatory disease. dcs have the ability to process and present antigens (mainly oxidized low-density lipoproteins, heat shock proteins and fragments of necrotic or apoptotic cells) to naïve T cells, and the activation of T cells is a key step for the progression of atherosclerotic disease. The existence of some distinct dc subtypes has now become evident. The main categories of dc subsets are the 'conventional or myeloid' and the 'plasmacytoid', which differ in toll-like receptor type and site of expression, pathogens and antigens recognized, and effector cytokines and functions. Studies on the potential impact of dcs in the pathogenesis of aTS may lead to novel therapies to regulate the immunoreactions occurring in atherogenesis. in particular, diltiazem, peroxisome proliferator activated receptor agonists and statins have been shown to protect endothelial cell function by inhibiting dcs, a mechanism that may play a significant role in the prevention of ATS.

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Ciglitazone Inhibits Oxidized-Low Density Lipoprotein Induced Immune Maturation of Dendritic Cells

Abstract: Our study suggested that one of the anti-inflammatory mechanisms of PPAR-gamma agonist ciglitazone was mediated by inhibiting the ox-LDL induced maturation and immune function of DCs.

Cited by 29 publications

References 27 publications

Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway

Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway

Dendritic cells and their role in atherogenesis

The functional role of dendritic cells in atherogenesis (Review)

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Ciglitazone Inhibits Oxidized-Low Density Lipoprotein Induced Immune Maturation of Dendritic Cells

Abstract: Our study suggested that one of the anti-inflammatory mechanisms of PPAR-gamma agonist ciglitazone was mediated by inhibiting the ox-LDL induced maturation and immune function of DCs.

Cited by 29 publications

References 27 publications

Danhong Inhibits Oxidized Low-Density Lipoprotein&ndash;Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>&gamma;</I>&ndash;Mediated Pathway

Danhong Inhibits Oxidized Low-Density Lipoprotein&ndash;Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>&gamma;</I>&ndash;Mediated Pathway

Dendritic cells and their role in atherogenesis

The functional role of dendritic cells in atherogenesis (Review)

Contact Info

Product

Resources

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Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway

Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor <I>γ</I>–Mediated Pathway