Ciguatera, an Emerging Human Poisoning in Europe

Acosta, F.

doi:10.15406/jamb.2015.03.00053

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…Until the 2000s, the distribution of ciguatera-causing organisms and ciguatoxic fish were thought to be limited to regions between latitudes 35 • N and 35 • S, with the highest poisoning incidence rates consistently reported from two tropical, historical CP-endemic areas, the Pacific and Caribbean regions [4] (for review and references therein) and [25,26], which is a situation due in part to the strong reliance of local communities on marine resources. The first reports of consumer illness and/or detection of ciguatoxic fish caught in previously non-endemic areas can be found in the literature as early as 2004 from localized areas such as the Macaronesia (Canary Islands, Madeira) [27][28][29][30][31][32][33][34][35][36], the eastern Mediterranean [37], the Gulf of Mexico [38], or the coast of Cameroon in West Africa [21]. In most of these instances, confirmation of the presence of CTXs in implicated toxic meals was consistent with the detection of Gambierdiscus species within the respective regions [38][39][40][41][42][43][44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Evidence for the Range Expansion of Ciguatera in French Polynesia: A Revisit of the 2009 Mass-Poisoning Outbreak in Rapa Island (Australes Archipelago)

Chinain

Gatti

Ung

et al. 2020

Toxins

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Ciguatera poisoning (CP) results from the consumption of seafood contaminated with ciguatoxins (CTXs). This disease is highly prevalent in French Polynesia with several well-identified hotspots. Rapa Island, the southernmost inhabited island in the country, was reportedly free of CP until 2007. This study describes the integrated approach used to investigate the etiology of a fatal mass-poisoning outbreak that occurred in Rapa in 2009. Symptoms reported in patients were evocative of ciguatera. Several Gambierdiscus field samples collected from benthic assemblages tested positive by the receptor binding assay (RBA). Additionally, the toxicity screening of ≈250 fish by RBA indicated ≈78% of fish could contain CTXs. The presence of CTXs in fish was confirmed by liquid chromatography tandem mass spectrometry (LC-MS/MS). The potential link between climate change and this range expansion of ciguatera to a subtropical locale of French Polynesia was also examined based on the analysis of temperature time-series data. Results are indicative of a global warming trend in Rapa area. A five-fold reduction in incidence rates was observed between 2009 and 2012, which was due in part to self-regulating behavior among individuals (avoidance of particular fish species and areas). Such observations underscore the prominent role played by community outreach in ciguatera risk management.

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Section: Introductionmentioning

confidence: 99%

Evidence for the Range Expansion of Ciguatera in French Polynesia: A Revisit of the 2009 Mass-Poisoning Outbreak in Rapa Island (Australes Archipelago)

Chinain

Gatti

Ung

et al. 2020

Toxins

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“…However, CTXs are emerging in places not previously expected according to their latitude, particularly in Europe. In recent years, several species of Gambierdiscus have been found in the Canary Islands, − where several CFP outbreaks have also occurred. − CTXs have also been detected in fish from other areas of the Macaronesia, i.e., Azores and Madeira archipelagos (Portugal). , Gambierdiscus sp., G. australes , and F. paulensis have been recorded in the Mediterranean Sea.…”

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confidence: 99%

Addressing the Analytical Challenges for the Detection of Ciguatoxins Using an Electrochemical Biosensor

et al. 2020

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The importance of ciguatoxins (CTXs) in seafood safety and their emerging occurrence in locations far away from tropical areas highlight the need for simple and low-cost methods for the sensitive and rapid detection of these potent marine toxins to protect seafood consumers. Herein, an electrochemical immunosensor for the detection of CTXs is presented. A sandwich configuration is proposed, using magnetic beads (MBs) as immobilization supports for two capture antibodies, with their combination facilitating the detection of CTX1B, CTX3C, 54-deoxyCTX1B, and 51-hydroxyCTX3C. PolyHRP-streptavidin is used for the detection of the biotinylated detector antibody. Experimental conditions are first optimized using colorimetry, and these conditions are subsequently used for electrochemical detection on electrode arrays. Limits of detection at the pg/mL level are achieved for CTX1B and 51-hydroxyCTX3C. The applicability of the immunosensor to the analysis of fish samples is demonstrated, attaining detection of CTX1B at contents as low as 0.01 μg/kg and providing results in correlation with those obtained using mouse bioassay (MBA) and cell-based assay (CBA), and confirmed by liquid chromatography coupled to high-resolution mass spectrometry (LC-ESI-HRMS). This user-friendly bioanalytical tool for the rapid detection of CTXs can be used to mitigate ciguatera risk and contribute to the protection of consumer health.

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“…Ciguatera poisoning (CP) is the most common seafood-borne poisoning worldwide [1]. Though originally endemic to tropical and intertropical regions, CP cases are now more commonly reported in semi-temperate areas in countries such as the Macaronesian Islands [2][3][4][5] or in the coast of continental countries such as India [6,7]. With an estimated 50,000 to 500,000 yearly cases worldwide, CP highest incidence rates (IRs) are consistently reported in endemic areas, i.e., the Caribbean Sea, and the Pacific and Indian Oceans [1,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Since no field test kit is available yet for immediate use by local communities and fishermen, local populations in PICTs often turn to a variety of folk tests [23,24] or strategies (avoidance consumption of too big portions, large carnivorous fish, specific parts of the fish, or certain species) to limit the risk of exposure to ciguatera toxins [13]. In some countries, current risk management regulatory practices include bans on the sale of high-risk fish species [25][26][27][28], those from known toxic locations [28], or specimens over a certain size [29][30][31][32][33][34] or weight [5,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Age and Growth Relationship to Ciguatoxicity in Five Coral Reef Fish Species from French Polynesia

et al. 2022

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Ciguatera poisoning (CP) results from the consumption of coral reef fish or marine invertebrates contaminated with potent marine polyether compounds, namely ciguatoxins. In French Polynesia, 220 fish specimens belonging to parrotfish (Chlorurus microrhinos, Scarus forsteni, and Scarus ghobban), surgeonfish (Naso lituratus), and groupers (Epinephelus polyphekadion) were collected from two sites with contrasted risk of CP, i.e., Kaukura Atoll versus Mangareva Island. Fish age and growth were assessed from otoliths’ yearly increments and their ciguatoxic status (negative, suspect, or positive) was evaluated by neuroblastoma cell-based assay. Using permutational multivariate analyses of variance, no significant differences in size and weight were found between negative and suspect specimens while positive specimens showed significantly greater size and weight particularly for E. polyphekadion and S. ghobban. However, eating small or low-weight specimens remains risky due to the high variability in size and weight of positive fish. Overall, no relationship could be evidenced between fish ciguatoxicity and age and growth characteristics. In conclusion, size, weight, age, and growth are not reliable determinants of fish ciguatoxicity which appears to be rather species and/or site-specific, although larger fish pose an increased risk of poisoning. Such findings have important implications in current CP risk management programs.

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Ciguatera, an Emerging Human Poisoning in Europe

Cited by 11 publications

References 31 publications

Evidence for the Range Expansion of Ciguatera in French Polynesia: A Revisit of the 2009 Mass-Poisoning Outbreak in Rapa Island (Australes Archipelago)

Evidence for the Range Expansion of Ciguatera in French Polynesia: A Revisit of the 2009 Mass-Poisoning Outbreak in Rapa Island (Australes Archipelago)

Addressing the Analytical Challenges for the Detection of Ciguatoxins Using an Electrochemical Biosensor

Evaluating Age and Growth Relationship to Ciguatoxicity in Five Coral Reef Fish Species from French Polynesia

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