Ciliated Hepatic Foregut Cysts: Not as Rare as Previously Believed

Hughes, Daniel Llwyd; Tsakok, Maria; Patel, Nikhil; Rendek, Anikó; Bungay, Helen; Silva, Michael A.

doi:10.1177/10668969221095263

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Supporting this "fail-safe" hypothesis, several medical reports reveal the existence of MCC in cysts that have been found in a wide variety of normally non multiciliatedorgans (e.g. in (37)(38)(39)(40)). Such potential for multiciliation in a progenitor cell could also underpin the observed formation of MCC along the lumen of non-MCC fluid producing tissues (kidney, urethra) in pathological situations where they could contribute to restore fluid flow (41)(42)(43).…”

Section: Discussionmentioning

confidence: 93%

Identification of a new cell cycle variant during multiciliated cell differentiation

Serizay,

Damaa,

Boudjema

et al. 2024

Preprint

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A complex and conserved regulatory network drives the cell cycle. Individual components of this network are sometimes used in differentiated cells, i.e. to control organelle destruction in mammalian lens cells or light response in land plants. Some differentiated cells co-opt cell-cycle regulators more largely, to increase their ploidy using a cell cycle variant named endoreplication. Using single-cell RNA-seq profiling and functional assays in differentiating multiciliated cells, we identified a novel type of cell cycle variant that supports cytoplasmic organelle, rather than nuclear content amplification. This variant operates in post-mitotic, centriole-amplifying differentiating multiciliated cells and is characterized by (i) a circular trajectory of the transcriptome, (ii) sequential expression of more than 70% of the genes involved in S, G2 and M-like progression along this trajectory, and (iii) successive waves of cyclins. This cell cycle variant is tailored by the expression of the non-canonical cyclins O and A1 - which replace the transcriptionally silent cyclins E2 and A2 - and by the silencing of the APC/C inhibitor Emi1, two switches also detected in male meiosis, another variant of the canonical cell cycle where centriole and DNA replications are uncoupled. Re-expressing Cyclin E2, cyclin A2 or Emi1 is sufficient to induce partial replication and mitosis, suggesting that change in the regulation of expression of a few cell cycle key players drives a qualitative and quantitative tuning of Cdk activity, allowing the diversion of the cell cycle in the multiciliation variant. We also propose that this new cell cycle variant relies on the existence of a cytoplasmic - or centriolar - Cdk threshold, lower than the S-phase threshold, which affects only the cytoplasmic reorganization.

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Section: Discussionmentioning

confidence: 93%

Identification of a new cell cycle variant during multiciliated cell differentiation

Serizay,

Damaa,

Boudjema

et al. 2024

Preprint

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“…It is postulated that the presence of hepatic cysts and hepatolithiasis may be associated with primary hepatic SCC, as chronic inflammation caused by infection of hepatic cysts and irritation of bile ducts by stones could potentially induce squamous metaplasia and subsequent transformation ( 41 , 50 ). Ciliated hepatic foregut cysts (CHFCs) are rare cystic lesions found in the liver, which have the potential to undergo malignant transformation, leading to the development of primary SCC ( 55 ). The clinical manifestations of hepatic primary SCC lack specificity, and there are no specific indicators in laboratory examinations and imaging findings, leading to the patients being typically diagnosed at an advanced stage.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic squamous cell carcinoma: case report and systematic review of the literature

Zhao,

Zhou,

Ding

et al. 2023

Front. Oncol.

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Primary hepatic squamous cell carcinoma (SCC) is extremely rare, and only a few dozen cases have been reported to date. It can barely be diagnosed before histopathological examination, which necessitates the exclusion of metastatic tumors. In this case, we present a 60-year-old female patient with no comorbidity. As laboratory tests and imaging examinations were not diagnostic, ultrasonography (US)-guided liver biopsy was performed and eventually revealed a definitive pathological diagnosis of hepatic SCC. After excluding metastasis, the diagnosis of primary hepatic SCC was established, and then chemotherapy and immunotherapy were performed. Additionally, a comprehensive literature search was conducted on primary hepatic SCC using PubMed, Google Scholar, and Web of Science, and a total of 53 articles were retrieved with a time range from 1972 to 2022. A critical analysis was then performed to evaluate previous literature focusing on the clinical characteristics, imaging features, treatments, and prognosis.

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