Ciliated muconodular papillary tumor of the peripheral lung: A newly defined rare tumor

Harada, Toshiyuki; Akiyama, Yasushi; Ogasawara, Hideki; Kishi, Fujiya; Hattori, Atsuo; Okamoto, Ken‐ichi; Hiramatsu, Masayuki; Ishikawa, Yuichi

doi:10.1016/j.rmedc.2008.04.005

Cited by 35 publications

(43 citation statements)

References 4 publications

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“…[1][2][3][4][5] CMPTs are small peripheral nonendobronchial lung nodules arising in middle-aged and older asymptomatic patients. Often incidentally discovered by CT screening, CMPTs commonly receive a radiologic interpretation of adenocarcinoma owing to the peripheral location and irregular contour.…”

Section: Discussionmentioning

confidence: 99%

“…A similar indolent clinical course was documented in all reported CMPTs. [1][2][3][4][5] A benign nature for CMPT is readily implied histologically, not only by the constant presence of cilia, but also by bland cytology, the lack of mitotic figures, and the consistent basal cell population. Nonetheless, the longterm biological behavior of CMPTs could not be established by the present study with a limited follow-up, and further data need to be collected to draw solid conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Ten cases with characteristic features of CMPT as described in the literature [1][2][3][4][5] were identified between 2006 and 2014. The clinical and pathologic records were reviewed, and a histologic analysis of the resected specimens was performed.…”

Section: Patients and Clinicopathologic Analysismentioning

confidence: 99%

“…The tumor showed an indolent course and nonatypical cytologic properties, so the authors suspected that CMPTs represented a benign neoplasm. Only 5 similar tumors have been subsequently reported as CMPTs in the English-language literature, [2][3][4][5] but its clinicopathologic features have not been analyzed in a sizable series. In addition, variable terminologies have been proposed for histologically similar, if not identical, tumors, including "solitary peripheral ciliated glandular papillomas," "mucinous adenomatous hyperplasia," and "peripheral pulmonary papillary/glandular neoplasms with ciliated cells," [6][7][8][9][10] and their relationship to CMPTs is poorly understood.…”

mentioning

confidence: 99%

“…In addition, variable terminologies have been proposed for histologically similar, if not identical, tumors, including "solitary peripheral ciliated glandular papillomas," "mucinous adenomatous hyperplasia," and "peripheral pulmonary papillary/glandular neoplasms with ciliated cells," [6][7][8][9][10] and their relationship to CMPTs is poorly understood. Furthermore, the great majority of these reports originated from East Asia, [1][2][3][4][5][6][8][9][10] and these ciliated lesions do not seem to have received global attention.…”

mentioning

confidence: 99%

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Ciliated Muconodular Papillary Tumors of the Lung

Kamata

Yoshida

Kosuge

et al. 2015

American Journal of Surgical Pathology

129

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Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean diameter of 1.0 cm. All but 1 tumor were incidentally detected by computed tomography-based screening, all of which were radiologically interpreted as adenocarcinomas. Although limited surgery treated all but 1 CMPT, they followed a benign course with no recurrence at a mean follow-up of 43 months (range: 2 to 88 mo). Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin. Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas. Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α expression. CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Patients and Clinicopathologic Analysismentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Ciliated Muconodular Papillary Tumors of the Lung

Kamata

Yoshida

Kosuge

et al. 2015

American Journal of Surgical Pathology

129

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Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations

Mikubo

Maruyama

Kakinuma

et al. 2019

Diagnostic Cytopathology

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Ciliated muconodular papillary tumors (CMPTs) of the lung are rare, likely benign neoplastic lesions. Here we describe a case of a CMPT, focusing on its cytologic features, which to our knowledge have not been reported previously. Owing to dull back pain, a 69‐year‐old male non‐smoker underwent CT, which revealed a 1.3 × 1.3‐cm solid nodule in the peripheral field of the left lower lung lobe. A wedge resection of the nodule was performed, with the provisional diagnosis being primary lung cancer. Macroscopic examination of a resected specimen showed a 1.2‐cm grayish nodule. Touch imprint smear cytology revealed ciliated columnar cells and mucous cells, as well as abundant extracellular mucin on inflammatory background of lymphocytes and histiocytes. Histologic examination revealed a nodular papillary tumor composed of ciliated columnar cells, mucous cells, and basal cells surrounded by a mucin pool. No nuclear atypia or mitotic figures were identified. The final diagnosis was CMPT. The postoperative course was uneventful, with no recurrence at 8 months after surgery. Although a CMPT is a rare lung tumor, it should be considered when cytological or histological examination of a solitary peripheral lung nodule shows non‐atypical ciliated cells and mucous cells surrounded by mucin.

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Benign and borderline tumors of the lungs and pleura

Wick¹,

Mills²

2024

Practical Pulmonary Pathology

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Ciliated muconodular papillary tumor of the peripheral lung: A newly defined rare tumor

Cited by 35 publications

References 4 publications

Ciliated Muconodular Papillary Tumors of the Lung

Ciliated Muconodular Papillary Tumors of the Lung

Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations

Benign and borderline tumors of the lungs and pleura

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