2013
DOI: 10.1242/jcs.111674
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Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl

Abstract: There was an error published in J. Cell Sci. 126,[196][197][198][199][200][201][202][203][204][205][206][207][208] The sequence of MO sdpI_e3i3 was reported incorrectly in the Materials and Methods section. The correct sequence of the MO sdpI_e3i3 used for this study is gtcaaaatccttcctcacCTCTCTC.We apologise for this mistake. Summary During development, general body plan information must be translated into distinct morphologies of individual cells. Shaping cells is thought to involve cortical cytoskeletal comp… Show more

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Cited by 26 publications
(37 citation statements)
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“…Although it is dispensable for ciliogenesis, ASAP1 serves as a scaffold for the recruitment and activation of the Rab11-Rabin8-Rab8 cascade to facilitate the ciliary targeting of rhodopsin in retinal photoreceptor cells (58). The F-BAR protein syndapin I localizes around the base of cilia, and its KD in zebrafish leads to defects in left-right body asymmetry and sensory hair cells (59), both of which depend on the proper functions of cilia. Missing in metastasis (MIM) is a member of the I-BAR subfamily (60).…”
Section: Discussionmentioning
confidence: 99%
“…Although it is dispensable for ciliogenesis, ASAP1 serves as a scaffold for the recruitment and activation of the Rab11-Rabin8-Rab8 cascade to facilitate the ciliary targeting of rhodopsin in retinal photoreceptor cells (58). The F-BAR protein syndapin I localizes around the base of cilia, and its KD in zebrafish leads to defects in left-right body asymmetry and sensory hair cells (59), both of which depend on the proper functions of cilia. Missing in metastasis (MIM) is a member of the I-BAR subfamily (60).…”
Section: Discussionmentioning
confidence: 99%
“…Cobl is enriched in the brain, where it plays an important role in dendritic arborization [9, 24, 25]. Cobl's nucleation activity has also been linked to primary cilia formation [26, 27] and microvillar assembly [28] and length regulation [29]. …”
Section: Opinionmentioning
confidence: 99%
“…Signaling to the actin cytoskeleton can occur via the I-bar domain since it can induce strong PI(4,5)P2 clustering 80 . In zebrafish, loss of function studies also find defects in ciliary structures which were directly related to BAR protein function 81 . These proteins have not yet been shown to have a role in early development or morphogenesis.…”
Section: Sensing Mechanical Signalsmentioning
confidence: 99%