Ciliogenesis is intrinsically altered in COPD small airways

Luczka-Majérus, Emilie; Bonnomet, Arnaud; Germain, A; Lalun, Nathalie; Kileztky, Claire; Perotin, Jeanne-Marie; Deslée, G.; Delépine, G.; Polette, Myriam; Dormoy, Valérian; Coraux, Christelle

doi:10.1183/13993003.00791-2022

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…28,29 The main feature of COPD is progressive and irreversible airflow obstruction. 30,31 Small airway dysfunction in patients with COPD results in luminal narrowing, which further causes airflow obstruction. 5,6,32 The GOLD employs airway obstruction as one of the criteria for diagnosing COPD.…”

Section: Discussionmentioning

confidence: 99%

Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Li,

et al. 2024

COPD

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Section: Discussionmentioning

confidence: 99%

Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Li,

et al. 2024

COPD

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“…Dysfunction of motile cilia was evaluated in the airways of COPD patients using a wide range of experimental tools from genetic studies to live imaging (table 1, [10,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]). The main findings commonly included decreased CBF, shortening of motile cilia, and ciliary dyskinesia from the nasal epithelium to the bronchioles (table 1).…”

Section: Alteration Of Motile Ciliamentioning

confidence: 99%

Airway ciliated cells in adult lung homeostasis and COPD

Petit,

Belgacemi,

Ancel

et al. 2023

Eur Respir Rev

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Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia are at the centre of fundamental sensory processes and are involved in a wide range of human disorders. Pulmonary cilia include motile cilia lining the epithelial cells of the conductive airways to orchestrate mucociliary clearance, and primary cilia found on nondifferentiated epithelial and mesenchymal cells acting as sensors and cell cycle keepers. Whereas cilia are essential along the airways, their regulatory molecular mechanisms remain poorly understood, resulting in a lack of therapeutic strategies targeting their structure or functions. This review summarises the current knowledge on cilia in the context of lung homeostasis and COPD to provide a comprehensive overview of the (patho)biology of cilia in respiratory medicine with a particular emphasis on COPD.

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Using Zebrafish to Study Multiciliated Cell Development and Disease States

Nguyen,

Baker,

Rodriguez

et al. 2024

Cells

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Multiciliated cells (MCCs) serve many important functions, including fluid propulsion and chemo- and mechanosensing. Diseases ranging from rare conditions to the recent COVID-19 global health pandemic have been linked to MCC defects. In recent years, the zebrafish has emerged as a model to investigate the biology of MCCs. Here, we review the major events in MCC formation including centriole biogenesis and basal body docking. Then, we discuss studies on the role of MCCs in diseases of the brain, respiratory, kidney and reproductive systems, as well as recent findings about the link between MCCs and SARS-CoV-2. Next, we explore why the zebrafish is a useful model to study MCCs and provide a comprehensive overview of previous studies of genetic components essential for MCC development and motility across three major tissues in the zebrafish: the pronephros, brain ependymal cells and nasal placode. Taken together, here we provide a cohesive summary of MCC research using the zebrafish and its future potential for expanding our understanding of MCC-related disease states.

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Ciliogenesis is intrinsically altered in COPD small airways

Cited by 3 publications

References 14 publications

Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Airway ciliated cells in adult lung homeostasis and COPD

Using Zebrafish to Study Multiciliated Cell Development and Disease States

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