Cilnidipine, an L/N-type calcium channel blocker prevents acquisition and expression of ethanol-induced locomotor sensitization in mice

Bhutada, Pravinkumar; Mundhada, Yogita; Patil, Jayashree; Rahigude, Anand; Zambare, Krushna; Deshmukh, Prashant; Tanwar, Dhanshree; Jain, Kishor S.

doi:10.1016/j.neulet.2012.02.064

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…One such blocker that is used currently in the clinic is cilnidipine (Atelec/ Cilacar; Fuji/Ajinomoto), an antihypertensive from the dihydropyridine class 70 . Importantly, this compound suppresses ethanol-induced locomotor sensitization in rats 198 .…”

Section: Amygdalamentioning

confidence: 95%

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

Zamponi

2015

Nat Rev Drug Discov

342

331

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Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.

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Section: Amygdalamentioning

confidence: 95%

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

Zamponi

2015

Nat Rev Drug Discov

342

331

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“…Cilnidipine, a mixed L/N type calcium channel blocker has been reported to block acquisition and sensitization to ethanol [2]. In light of the current findings, it is probable that the efficacy of cilnidipine is due to blockade of N-type calcium channels.…”

Section: Discussionmentioning

confidence: 69%

“…L-type calcium channel blockers block the stimulant effects of ethanol [1] as well as cross-sensitization between ethanol and nicotine [3]. A mixed L/N calcium channel blocker was reported to prevent both the acquisition and expression of sensitization to ethanol [2]. However, it has not been determined if specific L-type calcium channel blockers prevent sensitization to ethanol.…”

Section: Introductionmentioning

confidence: 99%

The role of L-type calcium channels in the development and expression of behavioral sensitization to ethanol

Broadbent

2013

Neuroscience Letters

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Behavioral sensitization is thought to play a significant role in drug addiction. L-type calcium channels have been implicated in sensitization to stimulant and opiate drugs but it is unclear if these channels also contribute to sensitization to ethanol. The effects of three L-type calcium channel blockers, nifedipine (1 – 7.5 mg/kg), diltiazem (12.5 – 50 mg/kg), and verapamil (12.5 and 25 mg/kg), on sensitization to ethanol (2 g/kg) were examined in DBA/2J mice. All three blockers reduced but did not prevent expression of sensitization. Only nifedipine blocked acquisition of sensitization. Nifedipine and verapamil decreased blood ethanol levels. The current findings suggest L-type calcium channels do not play a substantial role in sensitization to ethanol and that the neural mechanisms underlying sensitization to ethanol are distinct from those mediating sensitization to stimulants and opiates.

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Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression

Camarini

Pautassi

2016

Brain Research Bulletin

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Cilnidipine, an L/N-type calcium channel blocker prevents acquisition and expression of ethanol-induced locomotor sensitization in mice

Cited by 4 publications

References 39 publications

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

The role of L-type calcium channels in the development and expression of behavioral sensitization to ethanol

Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression

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