Cilnidipine regulates glucose metabolism and levels of high-molecular adiponectin in diet-induced obese mice

Abstract

The aim of the present study is to examine the effects of the antihypertensive drug cilnidipine on glucose metabolism and adipocytokines, including adiponectin, in diet-induced obese (DIO) mice. The effects of cilnidipine on insulin sensitivity and the levels of adiponectin in DIO mice were examined after the mice had been treated with cilnidipine dissolved in water at a dose of 0.2 g l(-1) for 14 days. As expected, treatment with cilnidipine decreased the systolic and diastolic blood pressures in DIO mice, compared with control mice (P<0.05 for each parameter). Cilnidipine treatment improved glucose and insulin sensitivity in DIO mice. In addition, cilnidipine treatment dramatically increased the level of adiponectin in white adipose tissue (P<0.05) and the circulating levels of total and high-molecular weight (HMW) adiponectin in DIO mice (P<0.01 for each parameter). Furthermore, the secretion of HMW adiponectin and the ratio of HMW adiponectin/total adiponectin were both increased after cilnidipine treatment. Finally, the secretion of adiponectin from adipocytes was increased after cilnidipine treatment. Taken together, these results indicate that cilnidipine improves insulin tolerance and adiponectin levels, especially high-molecular type adiponectin, in DIO mice.

Reduction in microalbuminuria by calcium channel blockers in patients with type 2 diabetes mellitus and hypertension-A randomized, open-label, active-controlled, superiority, parallel-group clinical trial

“…25 In addition, cilnidipine was reported to improve insulin sensitivity and glucose tolerance, possibly by increasing high-molecular weight adiponectin level in diet-induced obese mice. 26 However, in our analysis, fasting plasma glucose, HOMA-IR, lipid profile, hsCRP, and adiponectin levels were similar between the two groups. The anti-proteinuric effect of cilnidipine might be at least partly independent of its blood pressure-lowering effect.…”

“…Cilnidipine was reported to improve insulin sensitivity determined by the euglycemic clamp technique . In addition, cilnidipine was reported to improve insulin sensitivity and glucose tolerance, possibly by increasing high‐molecular weight adiponectin level in diet‐induced obese mice . However, in our analysis, fasting plasma glucose, HOMA‐IR, lipid profile, hsCRP, and adiponectin levels were similar between the two groups.…”

A Two‐for‐One Bargain: Using Cilnidipine to Treat Hypertension and Its Comorbidities

“…Cilnidipine also improved glucose tolerance and insulin sensitivity without effecting body weight or adiposity in hypertensive patients. Cilnidipine, therefore, may be a therapeutic tool for the metabolic syndrome . All the above‐mentioned protective actions of cilnidipine suggest that the drug may have the capability of treating patient comorbidities along with hypertension.…”

“…Cilnidipine, therefore, may be a therapeutic tool for the metabolic syndrome. 16 All the abovementioned protective actions of cilnidipine suggest that the drug may have the capability of treating patient comorbidities along with hypertension. Also, since the drug shows a variety of protective actions in different groups of hypertensive patients, it probably also has the potential to be optimized based on these additional disorders.…”