Ci̇lt Beyazlaticilara Genel Bakiş

Yapar, Evren Alğın

doi:10.12991/marupj.259880

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Melanin is also known to determine the color of hair, skin, and eyes depending on quantity, quality and distribution. Moreover, melanin synthesis disorders are believed to cause problems in skin pigmentation (Alğın Yapar, 2016).…”

Section: Skin and Melaninmentioning

confidence: 99%

“…The first stage in melanin synthesis is known to be highly critical with tyrosinase transformations leading to the formation of eumelanin and the formation of pheomelanin in the presence of cysteine and glutathione, while the other stages are proceed spontaneously at physiological pH. Hence, genetic factors are known to play an essential role in melanogenesis, whereas hormones proopiomelanocortin-derived peptides stimulate pigmentation, particularly in the sun-exposed areas, and other paracrine factors that are known to determine skin color include endothelin-1, stem cell factor, prostaglandins, and catecholamines (Alğın Yapar, 2016).…”

Section: Skin and Melaninmentioning

confidence: 99%

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Marine derived tyrosinase inhibitors

Pilevneli¹,

Konuklugil²

2020

EgeJFAS

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The cosmetics industry has gained strong momentum all over the world in recent years and has become a growing and promising sector. As it is known, as in the pharmaceutical industry, the cosmetic industry has also turned into becoming marine resources by seeking new materials for its continuation to be more productive for the field. To serve this purpose, marine-derived substances are highly claimed to be an interesting as well as a fruitful source for the benefits of the cosmetics industry. In this respect, as known globally, anti-tyrosinase inhibitors used in skin whitening are obtained from a considerable number of marine organisms. In this regard, the main objective of this article is to summarize a highly significant number of natural products derived from marine sources such as algae, fungi, seaweeds and bacteria which are known to have shown anti-tyrosinase activity.

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Section: Skin and Melaninmentioning

confidence: 99%

Section: Skin and Melaninmentioning

confidence: 99%

Marine derived tyrosinase inhibitors

Pilevneli¹,

Konuklugil²

2020

EgeJFAS

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“…amount of pigmentation in the skin may differ due to hereditary and/or acquired causes. Increase in hormones and enzymes leading to deterioration in melanocyte distribution and increase in melanin synthesis can lead to hyperpigmentation[9]. Druginduced hyperpigmentation accounts for 10-20% of acquired hyperpigmentation.…”

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confidence: 99%

The association between low serum Vitamin B12 levels and hyperpigmentation on patients who use Isotretinonin

Baysak¹,

Karagün

Ayvaz

2021

Health Sci. Q.

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Objective: Oral isotretinoin is the most effective agent in the treatment of acne vulgaris. The risk of pigmentation due to the systemic isotretinoin may be associated with decrease in serum levels of Vit B12. The study aims to contribute to the literature by defining the association between the increase in pigmentation caused by oral isotretinoin [O-ISO] use and low vitamin B12 level [vit-B12]. Methods: In our study we evaluated 144 patients, who have facial acnes at medium degree according to FDA Acne Score and take O-ISO treatment with the dose 0.5 mg/ kg/ day for six months. The relationship of the vitamin B12 levels of the patients at the admission and 6th month and the existence of pigmentation at 6th month, the skin type and the skin layer at which the pigmentation occurs, was evaluated.Association of vit-B12 level on admission and six months post drug use with the presence of pigmentation at six months, the type of skin and the skin layer in which pigmentation occurs were evaluated. Results: In the group with pigmentation, the mean vit-B12 level after six months of drug use was statistically lower than the mean vit-B12 level on admission [p <0.001]. In patients with no pigmentation, difference between the mean levels of Vit-B12 levels was not statistically significant [p = 0,255]. Conclusion: As a result, it was determined that the mean vit-B12 level decreased due to O-ISO use and the association of hyperpigmentation and low vit-B12 level was statistically significant. Vit -B12 monitoring and supplementation, if necessary, can help us prevent hyperpigmentation that may occur during the treatment.

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Ci̇lt Beyazlaticilara Genel Bakiş

Cited by 2 publications

References 13 publications

Marine derived tyrosinase inhibitors

Marine derived tyrosinase inhibitors

The association between low serum Vitamin B12 levels and hyperpigmentation on patients who use Isotretinonin

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