Cimetidine as a single oral dose for prophylaxis against Mendelson's syndrome*

Husemeyer, R. P.; Davenport, H. T.; Rajasekaran, Tanujaa

doi:10.1111/j.1365-2044.1978.tb08492.x

Cited by 46 publications

(11 citation statements)

References 14 publications

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“…In addition, the time interval between the administration of cimetidine and aspiration of the gastric contents was shorter in their study than ours and may not have allowed enough time for the drug to act. Our results do agree with Salmenpera et al [12], who report a marked reduction in the volume of gastric contents after cimetidine, but, in contrast to our study, others report no significant effects on gastric volume [13,14], In the Me group, 10% in our study had an intragastric volume of > 25 ml. This reduc tion in gastric volume was significant (p < 0.01) compared to our Co and An groups in contrast with other studies [8] which found no significant reduction; however, we agree with their findings of no effect on gastric pH.…”

Section: Discussioncontrasting

confidence: 54%

The Effect of Cimetidine, Magnesium Tri-Silicate Mixture, and Metoclopramide on Gastric pH and Volume

Khalid¹,

Al-Saigh²,

Farsakh

1989

Med Principles Pract

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Surgery patients are considered at risk for pulmonary acid aspiration if the gastric pH is 2.5 or less and/or the gastric aspirate volume is 25 ml or more. This study compares the effect of cimetidine, magnesium tri-silicate (MTS) and metoclopramide on the intragastric volume and pH in 120 elective surgery patients divided into four equal groups. Sixty to ninety minutes before anaesthesia, the cimetidine and metoclopramide groups received 300 and 10 mg i.m., respectively. One hundred twenty minutes before anaesthesia, the MTS group received 30 ml orally. Patients receiving MTS showed the highest gastric pH and intragastric volume. The cimetidine group had the lowest intragastric volume and a significant increase in pH. The metoclopramide group effectively reduced gastric volume but showed no significant effect on pH. We conclude that no single drug can be relied upon to reduce intragastric volume and neutralize gastric acid in all patients.

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Section: Discussioncontrasting

confidence: 54%

The Effect of Cimetidine, Magnesium Tri-Silicate Mixture, and Metoclopramide on Gastric pH and Volume

Khalid¹,

Al-Saigh²,

Farsakh

1989

Med Principles Pract

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“…They are also free of the possible risk of oral antacids having a direct toxic action on the lung. However, in emergency situations, oral antacids can act rapidly, 37 whereas H2 receptor antagonists, even given parenterally, need at least 45 5 59 minutes to act, ' and can have no effect on gastric contents present before administration.…”

Section: Discussionmentioning

confidence: 99%

H2 receptor antagonists and anaesthesia

Williams

1983

Can Anaesth Soc J

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“…Mendelson's syndrome is the pulmonary aspiration of acidic liquid gastric contents intra-operatively or early postoperatively in obstetric anaesthesia, leading to dyspnoea, cyanosis and shock [63] [64]. Antacid therapy has been an established treatment in the prophylaxis against Mendelson's syndrome [65] and magnesium trisillicate is superior to cimetidine in achieving a higher gastric pH [66].…”

Section: Magnesium In the Gastrointestinal Systemmentioning

confidence: 99%

Magnesium: The Neglected Electrolyte? A Clinical Review

Sharma¹,

Chung²,

Vizcaychipi³

2014

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Magnesium, Mg 2+ , is the second most abundant intracellular cation after potassium and the fourth most abundant in the body. It was first isolated in 1808 by the English chemist, Sir Humphrey Davy. Magnesium is essential to numerous biochemical reactions. It modulates key physiological processes such as metabolic biochemistry, nucleic acid synthesis, receptor-binding and ion flux. The western diet falls short of the recommended daily allowance of 4.5 mg/Kg/day and important dietary sources are seeds, grains, nuts and green vegetables. It is used as a therapeutic agent in a broad range of pathologies: neurological, cardiovascular, respiratory, gastrointestinal and obstetric. The pharmacokinetics and pharmacodynamics of magnesium, as a drug, are not well understood. Despite its fundamental importance to human physiology, it remains an electrolyte that is not routinely measured as part of the "urea & electrolytes" test and is the most overlooked electrolyte deficiency in hospital inpatients. This review will summarise the importance of magnesium homeostasis, its pharmacological effects and clinical applications.

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Cimetidine as a single oral dose for prophylaxis against Mendelson's syndrome*

Cited by 46 publications

References 14 publications

The Effect of Cimetidine, Magnesium Tri-Silicate Mixture, and Metoclopramide on Gastric pH and Volume

The Effect of Cimetidine, Magnesium Tri-Silicate Mixture, and Metoclopramide on Gastric pH and Volume

H2 receptor antagonists and anaesthesia

Magnesium: The Neglected Electrolyte? A Clinical Review

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