Cimetidine hydrochloride compatibility. III: Room temperature stability in drug admixtures

Yuhas, Elaine M.; Lofton, Frances T.; Rosenberg, Howard A.; Mayron, David; Baldinus, Joseph G.

doi:10.1093/ajhp/38.12.1919

Cited by 1 publication

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“…Cimetidine is compatible with standard intravenous solutions of electrolytes and dextrose or fructose [22,23] as well as with various types of parenteral nutrient solutions [24,25]; it can be mixed with these solutions to provide daily dosing with a single infusion set-up, which represents a potential savings in pharmacy costs to patients. Cimetidine may also reduce nursing time.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cimetidine and Placebo for the Prophylaxis of Upper Gastrointestinal Bleeding Due to Stress-related Gastric Mucosal Damage in the Intensive Care Unit

Karlstadt¹,

Iberti

Silverstein

et al. 1990

J Intensive Care Med

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placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit. J Intensive Care Med A multicenter, randomized, double-blind, placebocontrolled study was conducted with 87 patients in intensive care units to study the effectiveness of constant infusions of cimetidine (50 mg/hr) in the prophylaxis of stress-related mucosal bleeding. Fifty-four patients received cimetidine and 33 received placebo. The groups were comparable by age, sex, and severity of illness. One (2%) of the 54 patients receiving cimetidine had upper gastrointestinal hemorrhage and 7 (21%) of the 33 patients receiving placebo had upper gastrointestinal hemorrhage (p = 0.002). The risk of bleeding for every 100 patient days in intensive care units was reduced by 94% in the patients receiving cimetidine. Constant infusion cimetidine was well tolerated. Only one patient (cimetidine) developed pneumonia during the study, but it was not considered to be related to drug therapy. No patients experienced adverse drug interactions. Two patients (4%) experienced reversible side effects from treatment. Cimetidine, administered as a continuous intravenous 50-mg/hour infusion, is safe and significantly more effective than placebo for preventing upper gastrointestinal bleeding in critically ill patients.

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