CIMETIDINE IN DUODENAL ULCER Controlled Trial

Blackwood, Wesley; Pickard, Robert; Maudgal, D P; Lawrence, Diana M.; Northfield, T. C.

doi:10.1016/s0140-6736(76)92347-3

Cited by 133 publications

(36 citation statements)

References 10 publications

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“…Early clinical observations revealed that cimetidine in doses of 1.6 g day 21 could increase plasma creatinine concentrations by an average of 15% in patients with normal renal function [9,10]. Later studies showed that in high single doses, 300 mg i.v.…”

Section: Cimetidinementioning

confidence: 99%

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Andreev

Koopman

Arisz

1999

Journal of Internal Medicine

163

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Abstract. Andreev E, Koopman M, Arisz L (Medical University-Sofia, Sofia, Bulgaria and University of Amsterdam, Amsterdam, The Netherlands). A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible? (Review.) J Intern Med 1999; 246: 247±252. This is a review of the available information about drugs which cause an increase in plasma creatinine concentration without decreasing glomerular filtration rate (GFR). The GFR is the main, but not the single, determinant of the plasma creatinine levels. Several drugs, such as cimetidine, trimethoprim, corticosteroids, pyrimethamine, phenacemide, salicylates and active vitamin D metabolites, have been reported to increase plasma creatinine without influencing its glomerular filtration. Cimetidine, trimethoprim, pyrimethamine and salicylates can inhibit secretion of creatinine by the proximal tubule. Corticosteroids and vitamin D metabolites probably modify the production rate and the release of creatinine. The exact mechanism of phenacemide±creatinine interaction is not fully explained. These drug-induced alterations in plasma creatinine concentration have clinical significance when GFR is estimated by using plasma creatinine.

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Section: Cimetidinementioning

confidence: 99%

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Andreev

Koopman

Arisz

1999

Journal of Internal Medicine

163

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“…from ideal as a GFR marker because it is considerably influenced not only by GFR, but also by other factors including muscle mass, amount of ingested meat, and tubular secretion (2)(3)(4)(5)(6)(7)(8). Creatinine-based GFRestimating (eGFR creatinine ) equations that include demographic and anthropometric factors (9 -11 ) can partially compensate for the influence of muscle mass.…”

mentioning

confidence: 99%

Generation of a New Cystatin C–Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator

et al. 2014

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BACKGROUND Many different cystatin C–based equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays. METHODS Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high agreement and equivalence of 7 commercially available cystatin C assays allowed a substantial decrease of the CV of the assays, as defined by their performance in an external quality assessment for clinical laboratory investigations. By use of 2 of these assays and a population of 4690 subjects, with large subpopulations of children and Asian and Caucasian adults, with their GFR determined by either renal or plasma inulin clearance or plasma iohexol clearance, we attempted to produce a virtually assay-independent simple cystatin C–based equation for estimation of GFR. RESULTS We developed a simple cystatin C–based equation for estimation of GFR comprising only 2 variables, cystatin C concentration and age. No terms for race and sex are required for optimal diagnostic performance. The equation, eGFR=130×cystatin C−1.069×age−0.117−7, is also biologically oriented, with 1 term for the theoretical renal clearance of small molecules and 1 constant for extrarenal clearance of cystatin C. CONCLUSIONS A virtually assay-independent simple cystatin C–based and biologically oriented equation for estimation of GFR, without terms for sex and race, was produced.

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“…These changes in creatinine, although statistically significant (2,3), have been small, with values usually remaining within the normal range (1). Large changes in serum creatinine have not been reported, but their Occurrence is of potential importance both for differential diagnosis and for modification of dosage schedules for medications (4).…”

Section: To the Editormentioning

confidence: 99%