Cimetidine-Induced Acute Renal Failure

Rudnick, Michael R.; Bastl, C. P.; Elfenbein, I. Bruce; Sirota, Robert A.; Yudis, Melvin; Narins, Robert G.

doi:10.7326/0003-4819-96-2-180

Cited by 36 publications

(4 citation statements)

References 15 publications

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“…In the past, ulcer surgery (highly selective vagotomy with pyloroplasty) was recommended for patients with a history of ulceration; more recently, cimetidine therapy has to some extent supplanted vagotomy, although nephrotoxicity has been reported. 27 In the 1974-1979 Denver patients, we have not found chronic liver failure to be a major cause of death, in contrast to the experience at other centers, including the Peter Bent Brigham Hospital in Boston. 28 Although the follow-up period in this Denver series is shorter than in the Boston report, it is not clear why death from chronic liver failure was not observed in Denver.…”

Section: Gi Tractmentioning

confidence: 60%

Causes of Death After Kidney Transplantation

Washer¹

1983

JAMA

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Durtng the five-year period September 1074 through August '1979"two to the many physicians outside transhundred nine consecutive patients rec,lved their first kidney transplant In plant ~nterswho are now caring for Denver. During 2.5 to 7.5' years of foDow-up. 54 paUents (28%) died. kidney transplant patients. Infection was the leading cause of death during .. Interval. and was METHODS re.ponslble for 22 (41%) of the 54 deaths. Pneumonia was prtmarUy We, have reviewed the results of 209 re.ponslble for 14 of the 22 deaths from Infection. The other cau.e. of death CODSeCUtive patients who received their were cardiovascular problems In11 patient. (20%), suicide In eight paUents first kidney transplant at the University (15%). gastrOintestinal (GI) tract problems In .. ven paUents (13%), mangnsnt of Colorado Health Sciences Center and neopla.ms In two patient. (4%), and miscellaneous probIems-ln-four-paUentsthe Dcm¥R VeterlUlLAdminiatntioQ Hoe----' ,-'(7%). Twenty-alx ,(48%) of the 54 deaths occurred more than one year after pital during the fi.,.-year period Septemprtmary'transplantatlon; 12 of these 28 patlenla had already returned to ber 19"l4 throush August 1979. By meaDS of inpatient chart review, outpatient chart chronic hemodialysis. To minimize mortality atter transplantation, patients review, and telephone calldo patients and and their physician. must remain alert to the ongoing rt.ks to which the.. ,families, follow-up information for all paUent. are exposed, Including the rI.ks of sudden death from Infection.patients has been updated to Feb 1. U82. myocardial Infarction, pulmonary embolu., SUicide, or GI tract perforation. ~ range .or,foU cnr -Il P for the.155 lllniv-(JAifA 1983;250:4~54) • .. " ' / . 0 . patients ia 2.5 to 1.5, JUI'I (mean, 58 . ,. . months). Patients• _ho received a lint _ . ~ -' '~Diney transplaDt before •September 19'14

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Section: Gi Tractmentioning

confidence: 60%

Causes of Death After Kidney Transplantation

Washer¹

1983

JAMA

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“…Compared with non-users, H2RA users had a 35% higher risk of HA-AKI in our study. Indeed, the nephrotoxicity of H2RAs has been described in a number of sporadic case reports since 1977 (43,(48)(49)(50). However, two recent cohort studies in adults failed to find the significant association between H2RAs and AKI (42,51).…”

Section: Discussionmentioning

confidence: 99%

Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children

Li¹,

Xiong²,

Yang³

et al. 2020

Ann Transl Med

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Background: To evaluate the association between use of proton pump inhibitor (PPI) and the risk of hospital-acquired acute kidney injury (HA-AKI) in hospitalized children. Methods:We conducted a multicenter retrospective cohort study in hospitalized children aged 1 month to 18 years from 25 tertiary hospitals across China from 2013 to 2015. Patient-level data were obtained from the electronic hospitalization databases. AKI was defined and staged using the serum creatinine (SCr) data according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria.Results: Among 42,232 children analyzed, 11,496 (27.2%) used PPI, 1,760 (4.2%) used histamine 2 receptor antagonist (H2RA), and 3,514 (8.3%) had HA-AKI during hospitalization. Over 85% of PPIs were prescribed for prophylaxis of gastro-duodenal lesions in children. The use of PPI was associated with a significantly increased risk of HA-AKI compared with both non-users [odds ratio (OR), 1.37; 95% confidence interval (CI), 1.23-1.53)] and H2RA users (OR, 1.24; 95% CI, 1.01-1.52). The associations were consistent across children of different age range, gender, subtypes of PPIs and methods of administration. A larger effect was observed in children with chronic kidney disease (OR, 3.37; 95% CI, 2.46-4.62) and those

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“…These interactions with cimetidine are clinically significant because a decrease in drug clearance may lead to an increase in adverse effects, especially in the elderly and in those with impaired renal function. Numerous cases of acute interstitial nephritis have been reported with cimetidine therapy (Handa 1986;Kaye et al 1983;McGowan & Vermillion 1980;Richman et al 1981;Rudnick et al 1982). Renal biopsies of those cases all showed typical features of interstitial nephritis with infiltrates consisting of plasma cells, lymphocytes and eosinophils.…”

Section: Cimetidinementioning

confidence: 95%

Renal Effects of Peptic Ulcer Therapy

Burgess

Muruve

1992

Drug Safety

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Drugs used in the treatment of peptic ulcer disease may interact with the renal system in a variety of ways. Since many agents are eliminated by renal excretion, clearance of these agents may be reduced and half-life extended in the presence of renal insufficiency. The histamine H2-receptor antagonists may interfere with renal tubular excretion of creatinine and cationic drugs, resulting in elevated serum concentrations and reduced renal clearance. The prostaglandin E1 analogue misoprostol is used as a cytoprotective agent but has renal effects. The renal effects differ between systems studied. In the rat, misoprostol reduces cyclosporin-induced renal tubular toxicity, whereas in humans it has been shown to attenuate renal allograft rejection. Sucralfate is the aluminium salt of sucrose octasulfate. It permits the absorption of aluminium in amounts similar to aluminium-containing antacids, and toxicity has been demonstrated in the presence of renal insufficiency. Bismuth compounds are used increasingly to treat peptic ulcer disease, and bismuth toxicity has been described in association with renal insufficiency. Aluminium-, calcium- and magnesium-containing antacids are used as oral phosphate binders in patients with renal insufficiency in addition to their usual indications. Cation absorption and accumulation with all of these antacid preparations has been described and may lead to toxicity.

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Cimetidine-Induced Acute Renal Failure

Cited by 36 publications

References 15 publications

Causes of Death After Kidney Transplantation

Causes of Death After Kidney Transplantation

Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children

Renal Effects of Peptic Ulcer Therapy

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