Cimetidine Treatment of Reflux Esophagitis in Children

Cucchiara, Salvatore; Gobio-Casali, L; Balli, Fiorella; Magazzù, Giuseppe; Staiano, Annamaria; Astolfi, Rafael Haddad; Amarri, Sergio; S, Conti-Nibali; Guandalini, Stefano

doi:10.1097/00005176-198902000-00005

Cited by 52 publications

(29 citation statements)

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“…29,30. Randomized studies in children have also shown that compared with placebo, H 2 RAs are effective for erosive esophagitis. 31,32 Proton pump inhibitors (PPIs) are superior to H 2 RAs in relieving symptoms and healing esophagitis. 33 The current evidence supports the recommendation for the treatment of reflux esophagitis.…”

Section: Treatment Optionsmentioning

confidence: 99%

GERD or not GERD: the fussy infant

Bhatia

Parish

2009

J Perinatol

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Section: Treatment Optionsmentioning

confidence: 99%

GERD or not GERD: the fussy infant

Bhatia

Parish

2009

J Perinatol

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“…Até o momento, apenas a cimetidina 25 e a nizatidina 26,27 foram avaliadas em crianças em relação à evolução clínica da DRGE através de estudos controlados e randomizados. A cimetidina apresenta um grande número de interações medicamentosas.…”

Section: Esofagite Erosivaunclassified

Treatment of gastroesophageal reflux disease

Guimarães¹,

Marguet²,

Camargos³

2006

J Pediatr (Rio J)

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Objective: To review the literature on the treatment of gastroesophageal reflux disease (GERD) with emphasis on pharmacological aspects. To identify particularities of pharmacological treatment of esophageal and extraesophageal manifestations of the disease.Sources: Electronic search of the PubMed/MEDLINE and Cochrane Collaboration databases. Controlled and randomized studies published since 2000 and reviews representing consensus positions and directives published within the last 10 years were identified. Summary of the findings:The drugs currently available for the treatment of GERD do not act in the primary mechanism of the disease, i.e., transitory relaxation of the lower esophageal sphincter. Pharmacological treatment of GERD with symptoms or with esophageal injury is based on the suppression of acid secretion, particularly with proton pump inhibitors. When the hyperreactivity of the lower airways coexists with esophageal GERD symptoms, suppression of acid secretions should be of benefit in managing the respiratory disease in the presence of a causal relationship; however, this is not usual. When esophageal symptoms are not present, esophageal 24-hour pH study should be carried out prior to starting pharmacological treatment for GERD. Improvement of respiratory symptoms may be delayed with relation to esophageal symptoms. It is common for GERD to recur and pharmacological treatment should be repeated or continued indefinitely, depending on clinical presentation of the disease. Conclusions:The strategies that have been proposed for the pharmacological treatment of GERD in children are primarily based on studies of case series or on studies with adults. There have been very few controlled and randomized studies in children. Undertaking a greater number of these studies might reinforce existing aspects or establish new aspects of management.J Pediatr (Rio J). 2006;82(5 Suppl):S133-45: Gastroesophageal reflux, child, drug therapy, esophagitis, respiratory tract diseases, asthma. ResumoObjetivo: Rever a literatura sobre tratamento da doença do refluxo gastroesofágico (DRGE) com ênfase nos aspectos farmacológi-cos. Identificar particularidades do tratamento farmacológico nas manifestações esofágicas e extra-esofágicas da doença.Fontes de dados: Busca eletrônica na base de dados PubMed/ MEDLINE e Cochrane Collaboration. Procurou-se identificar estudos controlados e randomizados publicados a partir de 2000, bem como revisões que representassem consensos e diretrizes publicados nos últimos 10 anos.Síntese dos dados: Nenhuma das drogas atualmente usadas no tratamento da DRGE altera comprovadamente o mecanismo principal da doença, ou seja, os relaxamentos transitórios do esfíncter esofágico inferior. O tratamento farmacológico da DRGE com sintomas ou com lesões esofágicas é baseado na inibição da secreção ácida, em particular pelos inibidores da bomba de prótons (IBP). Nas situações em que a hiper-reatividade das vias aéreas inferiores coexiste com sintomas esofágicos da DRGE, a inibição da secreção ácida deve...

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“…H 2 -receptor antagonists, such as cimetidine (Tagamet), ranitidine (Zantac) and famotidine (Pepcid), are effective in healing reflux oesophagitis in infants [28,32,88]. High-dose ranitidine appears to be comparable to omeprazole in this respect [34].…”

Section: Antacids H 2 -Receptor Antagonists and Proton Pump Inhibitorsmentioning

confidence: 99%

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

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A critical appraisal of current management practices for infant regurgitation: recommendations of a working party Vandenplas, Y.; Belli, D.; Benhamou, P.; Cadramel, S.; Cezard, J.P.; Cucchiara, S.; Dupont, C.; Faure, C.; Gottrand, F.; Hassall, E.; Heymans, H.S.A.; Kneepkens, C.M.F.; Sandhu, B. Published in:European Journal of Pediatrics DOI:10.1007/s004310050613Link to publication Citation for published version (APA):Vandenplas, Y., Belli, D., Benhamou, P., Cadramel, S., Cezard, J. P., Cucchiara, S., ... Sandhu, B. (1997). A critical appraisal of current management practices for infant regurgitation: recommendations of a working party. European Journal of Pediatrics, 156, 343-357. DOI: 10.1007/s004310050613 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Abstract Regurgitation is a common manifestation in infants below the age of 1 year and a frequent reason of counselling of general practitioners and paediatricians. Current management starts with postural and dietary measures, followed by antacids and prokinetics. Recent issues such as an increased risk of sudden infant death in the prone sleeping position and persistent occult gastrooesophageal reflux in a subset of infants receiving milk thickeners or thickened ''anti-regurgitation formula'' challenge the established approach. Therefore, the clinical practices for management of infant regurgitation have been critically evaluated with respect to their efficacy, safety and practical implications.

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Cimetidine Treatment of Reflux Esophagitis in Children

Cited by 52 publications

References 0 publications

GERD or not GERD: the fussy infant

GERD or not GERD: the fussy infant

Treatment of gastroesophageal reflux disease

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

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