Cinacalcet, fetuin-A and interleukin-6

Marino, Angela; Giotta, Nicola

doi:10.1093/ndt/gfm856

Cited by 9 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Findings of this study show that LF/HF ratios from presleep, first NREM and first REM, but not from the last NREM or REM sleep periods, were significant predictors of IL‐6 after controlling for BMI. The nature of these relationships is consistent with the half‐lives reported for the respective cytokines, 2–4 h for IL‐6 and 20 h for CRP (Marino and Giotta, ). Thus, effects of autonomic activity on IL‐6 secretion during the first half of the sleep period would probably be reflected by morning levels, whereas effects on longer‐enduring CRP would not necessarily be evident the next morning.…”

Section: Discussionsupporting

confidence: 87%

Nocturnal autonomic nervous system activity and morning proinflammatory cytokines in young adult African Americans

Bell

Kobayashi

Chen

et al. 2017

Journal of Sleep Research

View full text Add to dashboard Cite

Compromised sleep and increased sympathetic nervous system (SNS) activity are implicated in the pathogenesis of, and disparities in, cardiovascular disease. Parasympathetic dominance during sleep may be important for cardiovascular health. Sleep and autonomic balance influence immune activity which impacts atherogenesis. We evaluated relationships between autonomic balance during sleep and morning levels of the immune activating cytokines, C-reactive protein (CRP) and Interleukin 6 (IL-6). Ninety four (59 female) young adult African Americans without medical conditions and substance use disorders spent two consecutive nights in a clinical research unit for sleep recordings and blood drawing on awakening. Cardiac tracings from the 2nd sleep recording were analyzed for heart rate variability (HRV). BMI was the only non-HRV measure correlated with cytokine levels. Indicators of SNS activity for the pre-sleep, and first non-REM and REM sleep periods were independently correlated with morning IL-6 levels. Altered autonomic balance during sleep may be a modifiable factor that influences immune activation.

show abstract

Section: Discussionsupporting

confidence: 87%

Nocturnal autonomic nervous system activity and morning proinflammatory cytokines in young adult African Americans

Bell

Kobayashi

Chen

et al. 2017

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…However, other multicellular components adopt sparse cell arrangements and exhibit autocrine signaling. Recent experiments have shown that glioblastoma tumor cells in groups of N ∼ 10 3 −10 4 secrete the autocrine factors IL-6 and VEGF [43], for which D ρ ∼ 30 µm 2 /s [44] and 100 µm 2 /s [45], and ν ∼ 0.2 hr −1 [46] and 0.7 hr −1 [47], respectively, yielding λ ∼ 700 µm. Indeed, in this regime, we would predict that sparse packing provides the higher sensory precision (Fig.…”

mentioning

confidence: 99%

Fundamental Limits to Collective Concentration Sensing in Cell Populations

Fancher

Mugler

2017

Phys. Rev. Lett.

View full text Add to dashboard Cite

The precision of concentration sensing is improved when cells communicate. Here we derive the physical limits to concentration sensing for cells that communicate over short distances by directly exchanging small molecules (juxtacrine signaling), or over longer distances by secreting and sensing a diffusive messenger molecule (autocrine signaling). In the latter case, we find that the optimal cell spacing can be large, due to a tradeoff between maintaining communication strength and reducing signal cross-correlations. This leads to the surprising result that sparsely packed communicating cells sense concentrations more precisely than densely packed communicating cells. We compare our results to data from a wide variety of communicating cell types.Single cells sense chemical concentrations with extraordinary precision. In some cases this precision approaches the physical limits set by molecular diffusion [1,2]. Yet, no cell performs this sensory task in isolation. Cells exist in communities, such as colonies, biofilms, and tissues. Within these communities, cells communicate in diverse ways. Communication mechanisms include the exchange of molecules between cells in contact (juxtacrine signaling), and secretion and detection of diffusible molecules over distances comparable to the cell size or longer (autocrine signaling [3]) [4][5][6][7]. This raises the question of whether cell-cell communication improves a cell's sensory precision, beyond what the cell achieves alone.Experiments have shown that cells are more sensitive in groups than they are alone. Groups of neurons [8], lymphocytes [9], and epithelial cells [10] exhibit biased morphological or motile responses to chemical gradients that are too shallow for cells to detect individually. Groups of cell nuclei in fruit fly embryos detect morphogen concentrations with a higher precision than is expected for a single nucleus [11][12][13]. In some cases, such as with epithelial cells [10], cell-cell communication has been shown to be directly responsible for the enhanced sensitivity. Yet, from a theoretical perspective, the fundamental limits to concentration sensing [1,2,[14][15][16][17][18][19][20] or gradient sensing [21][22][23] have been largely limited to single receptors or single cells. Analogous limits for groups of communicating cells have been derived only for specific geometries [24], and are otherwise poorly understood. In particular, it remains unknown whether the limits depend on the communication mechanism (juxtacrine vs. autocrine), and how they scale with collective properties like communication strength and population size.Here we derive the fundamental limits to the precision of collective sensing by one-, two-, and three-dimensional (3D) populations of cells. We focus on the basic task of sensing a uniform chemical concentration. We compare two ubiquitous communication mechanisms, juxtacrine signaling and autocrine signaling. Intuitively one expects that sensory precision is enhanced by communication, that communication is strongest when cells ...

show abstract

“…IL-6 levels, while previously shown to be associated with worse outcomes in patients with active breast cancer 25 , were not associated with an increased risk of relapse in the present analysis of HR+ breast cancer survivors. This potentially reflects the difference in half-lives between inflammatory cytokines like IL-6, which is measured on the order of hours 26 , as compared to their downstream acute phase proteins, like CRP and SAA, which can remain elevated for days and be detected more easily 18 .…”

Section: Discussionmentioning

confidence: 99%

Effects of systemic inflammation on relapse in early breast cancer

et al. 2021

View full text Add to dashboard Cite

Chronic inflammation has been a proposed mechanism of resistance to aromatase inhibitors in breast cancer. Stratifying by HER2 status, a matched case-control study from the Wellness After Breast Cancer-II cohort was performed to assess whether or not elevated serum inflammatory biomarkers (C-Reactive protein [CRP], interleukin-6 [IL-6], and serum amyloid A [SAA]) and/or the presence of a high-risk IL-6 promoter genotype were associated with recurrence of hormone receptor positive (HR+) early breast cancer. Estrogen levels were also measured and correlated with biomarkers and disease outcomes. CRP and SAA were significantly associated with an increased risk of recurrence in the HR+/HER2− group, but not the HR+/HER2+ group. Mean serum estrogen levels were non-significantly elevated in patients who relapsed vs. non-relapsed patients. Surprisingly, high-risk IL-6 promoter polymorphisms were strongly associated with HER2+ breast cancer relapse, which has potential therapeutic implications, as elevated intracellular IL-6 has been associated with trastuzumab resistance in pre-clinical models.

show abstract

Cinacalcet, fetuin-A and interleukin-6

Cited by 9 publications

References 5 publications

Nocturnal autonomic nervous system activity and morning proinflammatory cytokines in young adult African Americans

Nocturnal autonomic nervous system activity and morning proinflammatory cytokines in young adult African Americans

Fundamental Limits to Collective Concentration Sensing in Cell Populations

Effects of systemic inflammation on relapse in early breast cancer

Contact Info

Product

Resources

About