Cinchophen Oxidation Test of the Function of the Hepatic Cells

Factors Causing Clinical Jaundice in Heart Disease

“…13 A thorough study of the function of the liver was recently reported by Jolliffe 5 in 16 subjects with congestive failure, some with clinical jaundice. The most con¬ stant findings are urobilinogenuria 8 and urobilinuria.9 This has been attributed to increased destruction of blood because deposits of hemosiderin are to be seen in the lungs.10 A test of tolerance for water and exercise has elicited urobilinuria in latent heart failure.11 Bilirubin excretion tests, measuring the capacity of the liver to remove bilirubin administered parenterally, show a diminution of this function in heart failure.12 A metabolic test based on the capacity of the liver to oxidize cinchophen under standardized conditions also showed altered function in cases of congestion of the liver.…”