2019
DOI: 10.1016/j.nicl.2019.101925
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Cingulate glutamate levels associate with pain in chronic pancreatitis patients

Abstract: Aims Emerging evidence show that patients with chronic pancreatitis (CP) and abdominal pain have structural and functional alterations in the central nervous system. The aim was to investigate cerebral metabolic signatures in CP and the associations to various risk factors/clinical characteristics and patient outcomes. Methods Magnetic resonance spectroscopy was used to measure brain metabolites in the anterior cingulate cortex (ACC), insula, prefrontal cortex and the p… Show more

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Cited by 14 publications
(5 citation statements)
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“…Furthermore, previous studies have found that the ACC glutamate level was increased and associated with pain in chronic pain conditions. [36][37][38] In this present study, no association was demonstrated between the glu/cre ratio and experimentally induced pain scores, which were obtained after the MRI scan. Thus, the study showed decreased glu/cre after oxycodone and tapentadol treatments in the absence of pain.…”
Section: Discussioncontrasting
confidence: 75%
See 1 more Smart Citation
“…Furthermore, previous studies have found that the ACC glutamate level was increased and associated with pain in chronic pain conditions. [36][37][38] In this present study, no association was demonstrated between the glu/cre ratio and experimentally induced pain scores, which were obtained after the MRI scan. Thus, the study showed decreased glu/cre after oxycodone and tapentadol treatments in the absence of pain.…”
Section: Discussioncontrasting
confidence: 75%
“…ACC is a part of the limbic area where the affective component of pain is generated. Furthermore, previous studies have found that the ACC glutamate level was increased and associated with pain in chronic pain conditions 36–38 . In this present study, no association was demonstrated between the glu/cre ratio and experimentally induced pain scores, which were obtained after the MRI scan.…”
Section: Discussioncontrasting
confidence: 72%
“…Evidence suggests that Glu is a candidate biomarker for pain. Hansen et al (2019) showed that patients with a high level of Glu in the ACC report more severe abdominal pain. Legarreta et al (2021) found that in the ACC, the Glu/GABA ratio associated with anxiety and depression positively, and these mood disorders related to chronic pain may be attribute to the disturbance in the excitatory-inhibitory balance.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, in TNBS-induced CP, rats have increased glutamatergic signaling in the NTS-ACC circuit which correlates with both increased hypersensitivity and anxiety behaviors [53,77] ; this is consistent with human studies that detected elevated glutamate levels in ACC of patients with painful CP. [78] This suggests that the ACC could be a therapeutic target. Indeed, local inhibition of ACC neurons, via chemogenetic tools or AMPA and NMDA receptor antagonists, ameliorated both the hypersensitivity and anxiety produced in the TNBS rat model of CP.…”
Section: Mechanisms Of Central Sensitization In Pancreatitismentioning
confidence: 99%