Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine

Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

“…A study in pediatric bipolar patients found that valproate was actually neuroprotective for cingulate gyrus volume. 33 We did not find differences in volumes between those not treated with valproate and those treated with valproate, commonly the first-line treatment of choice in IGE. 34 In addition, no volume differences were evident between children whose first medication was valproate and children whose first medication was not valproate.…”

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

“…Indeed, mood stabilizers have been hypothesized to have a neuroprotective effect, indicated by increased anterior cingulate volumes in medicated as compared to unmedicated BP and HC. 65 Similarly, an increase of total gray matter volume after pharmacological treatment with lithium has been observed in healthy subjects 66 and BP. 67 Notwithstanding this potential confounding factor, an impact of volumetric seed masks' differences on the results is unlikely in the present study, as we did not observe volumetric differences for the respective seed masks.…”

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder

“…Fourth, despite covarying for medications, the possibility of residual psychotropic medication effects remains. [68][69][70][71] Fifth, the present cross-sectional data do not allow for analyses regarding the effect of duration of elevated BMI. Finally, the range of BMI was narrower in the control sample than the BD sample, which may explain in part the lack of negative correlation between BMI and ROIs in the control participants.…”