Cinnamaldehyde: A plant-derived antimicrobial for overcoming multidrug-resistant Acinetobacter baumannii infection

Thirapanmethee, Krit; Kanathum, Pohnvipa; Khuntayaporn, Piyatip; Huayhongthong, Sirichayaporn; Surassmo, Suvimol; Chomnawang, Mullika Traidej

doi:10.1016/j.eujim.2021.101376

Cited by 17 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…aeruginosa, leading to the collapse of membrane potential and loss of membrane-selective permeability, resulting in cell death [44]. Te authors of [45] demonstrated that cinnamaldehyde could elongate bacterial cell morphology and cause its lysis. In agreement with these results, our results showed that the increase in the amount of K + released from A. hydrophila cells after treatment of cinnamaldehyde, which provided the evidence that cinnamaldehyde increased the plasma membrane permeability, caused potassium ion leakage from treated cells, and then led to A. hydrophila cells death [46].…”

Section: Discussionmentioning

confidence: 99%

Study of Antibacterial Properties of Cinnamaldehyde against Aeromonas hydrophila

Pei

Sun

Liu

et al. 2023

Aquaculture Research

View full text Add to dashboard Cite

Antibacterial properties of cinnamaldehyde against Aeromonas hydrophila were assayed in this study. To investigate the action mechanisms of cinnamaldehyde against A. hydrophila, we examined the antibacterial activity, bacterial membrane permeability, and ultrastructure of A. hydrophila cells treated with cinnamaldehyde. The results showed that the minimum inhibitory concentration (MIC) value of cinnamaldehyde against A. hydrophila NJ-35 was found to be 0.039 mg/mL. The trends of the growth curve of A. hydrophila treated with different concentrations of cinnamaldehyde (from 1/4 MIC to 2 MIC) were different, and there was a significant difference in the growth curve of different groups of treatment. There were significant differences in the K+ concentration among all treatment groups from 1 h to 5 h after incubation compared with that of the control. The highest K+ concentration was observed in the 1 MIC group of cinnamaldehyde. The ultrastructure of A. hydrophila cells treated with cinnamaldehyde was destroyed, and the morphology changed. These results indicated that cinnamaldehyde could inhibit the growth of A. hydrophila, increase bacterial membrane permeability, and damage cell membrane integrity, resulting in leakage of the A. hydrophila cell contents.

show abstract

Section: Discussionmentioning

confidence: 99%

Study of Antibacterial Properties of Cinnamaldehyde against Aeromonas hydrophila

Pei

Sun

Liu

et al. 2023

Aquaculture Research

View full text Add to dashboard Cite

show abstract

“…trans -Cinnamaldehyde and eugenol in combination with seven β -lactam antibiotics, including ampicillin, methicillin, meropenem, penicillin, aztreonam, amoxicillin, and piperacillin, increased the sensitivity of A. baumannii to all the tested antibiotics 92 . Cinnamaldehyde exhibited a synergistic effect with imipenem and colistin, while in combination with ceftazidime, gentamicin, and amikacin, it displayed additive effects in most MDR A. baumannii isolates 93 . The norwogonin (5,6,7-trihydroxyflavone) extracted from Scutellaria baicalensis has good antibacterial activity against A. baumannii 94 .…”

Section: Herbal Products and Their Constituents Used Alone And In Com...mentioning

confidence: 98%

Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria

Herman

2022

Planta Med

View full text Add to dashboard Cite

The purpose of this review is to summarize the current knowledge acquired on herbal products and their active constituents with antimicrobial activity used alone and in combination with antibiotics against multidrug-resistant bacteria. The most promising herbal products and active constituents used alone against multidrug-resistant bacteria are Piper betle (methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended-spectrum beta-lactamase, Acinetobacter baumannii, Pseudomonas aeruginosa), Glycyrrhiza glabra (methicillin-resistant S. aureus, vancomycin-resistant Enterococcus, P. aeruginosa), and berberine (methicillin-resistant S. aureus, A. baumannii, P. aeruginosa), respectively. The synergistic effect of the combination of herbal products and their active constituents with antibiotics against multidrug-resistant bacteria are also described. These natural antibacterial agents can be promising sources of inhibitors, which can modulate antibiotic activity against multidrug-resistant bacteria, especially as efflux pump inhibitors. Other possible mechanisms of action of herbal therapy against multidrug-resistant bacteria including modification of the bacterial cell wall and/or membrane, inhibition of the cell division protein filamenting temperature sensitive Z-ring, and inhibition of protein synthesis and gene expression, all of which will also be discussed. Our review suggests that combination herbal therapy and antibiotics can be effectively used to expand the spectrum of their antimicrobial action. Therefore, combination therapy against multidrug-resistant bacteria may enable new choices for the treatment of infectious diseases and represents a potential area for future research.

show abstract

“…Usually, they are associated with respiratory and urinary tract infections or even bacteremia. Recently A. baumannii has been proclaimed as the most critical group, resistant to different classes of antibiotics ( Thirapanmethee et al, 2021 ). It belongs to the ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter species) group of pathogens and due to its potential to easily overcome antibiotic treatments, alternative strategies to combat the infections caused by it are necessary.…”

Section: Introductionmentioning

confidence: 99%

Cinnamon essential oil and its emulsion as efficient antibiofilm agents to combat Acinetobacter baumannii

et al. 2022

View full text Add to dashboard Cite

Acinetobacter baumannii is an emerging nosocomial pathogen resistant to a wide spectrum of antibiotics, with great potential to form a biofilm, which further aggravates treatment of infections caused by it. Therefore, searching for new potent agents that are efficient against A. baumannii seems to be a necessity. One of them, which has already been proven to possess a wide spectrum of biological activities, including antimicrobial effect, is cinnamon essential oil. Still, further increase of antibacterial efficacy and improvement of bioavailability of cinnamon oil is possible by emulsification process. The aim of this study was comparative analysis of cinnamon essential oil and its emulsion against biofilm forming A. baumannii clinical isolates. Furthermore, the investigation of toxicological aspects of possible applications of essential oil and emulsion was done as well. Gas chromatography–mass spectrometry of essential oil indicated trans-cinnamaldehyde as the most abundant component. The cinnamon emulsion was synthesized from cinnamon essential oil by combining modified low- and high- energy methods. Synthesized emulsion was characterized with Fourier-transform infrared spectroscopy and photon correlation spectroscopy. Both substances exhibited significant antibacterial (minimal inhibitory concentrations in the range 0.125–0.5 mg/ml) and antibiofilm effects (inhibitions of formation and reduction of pre-formed biofilm were 47–81 and 30–62%, respectively). Compared to essential oil, the efficacy of emulsion was even stronger considering the small share of pure oil (20%) in the emulsion. The result of biofilm eradication assay was confirmed by scanning electron microscopy. Even though the cytotoxicity was high especially for the emulsion, genotoxicity was not determined. In conclusion, strong antibacterial/antibiofilm effect against A. baumannii of the cinnamon essential oil and the fact that emulsification even potentiated the activity, seems to be of great significance. Observed cytotoxicity implicated that further analysis is needed in order to clearly determine active principles being responsible for obtained antibacterial/antibiofilm and cytotoxic properties.

show abstract

Cinnamaldehyde: A plant-derived antimicrobial for overcoming multidrug-resistant Acinetobacter baumannii infection

Cited by 17 publications

References 33 publications

Study of Antibacterial Properties of Cinnamaldehyde against Aeromonas hydrophila

Study of Antibacterial Properties of Cinnamaldehyde against Aeromonas hydrophila

Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria

Cinnamon essential oil and its emulsion as efficient antibiofilm agents to combat Acinetobacter baumannii

Contact Info

Product

Resources

About