Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial

Ranasinghe, Priyanga; Galappaththy, Priyadarshani; Constantine, Godwin; Jayawardena, Ranil; Weeratunga, Hasitha Dhananjaya; Premakumara, Sirimal; Katulanda, Prasad

doi:10.1186/s13063-017-2192-0

Cited by 45 publications

(23 citation statements)

References 28 publications

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“…Finally, the obtained ratio was used for the preparation of 700 mg capsules. The lethal dose value (LD50) of cinnamon is 1850 ±37 mg/kg in the animals, which is equivalent to a human dose of 11.4 ±0.2 g/kg [34] and that of C. sinensis, ginger, and spearmint is 4837.5 mg/kg [35], 5 g/kg [36], and 5000 mg/kg [37], respectively.…”

Section: Medicinal Plants and Capsule (700 Mg) Preparation And Standamentioning

confidence: 99%

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Ainehchi

Khaki

Ouladsahebmadarek

et al. 2020

aoms

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Introduction: To evaluate the effect of a herbal mixture (i.e., Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, and Citrus sinensis) alone and in combination with clomiphene citrate (CC) compared to CC on the treatment of polycystic ovary syndrome (PCOS). Material and methods: This single-blind randomized clinical trial was conducted on 60 infertile participants with PCOS who were randomly divided into three groups. After spontaneous or progestin-induced withdrawal bleeding, group 1 (n = 20) received routine treatment with CC (50-150 mg) for three menstrual cycles from the 3 rd to 5 th day of menstruation for 5 days while group 2 (n = 20) and group 3 (n = 20) received herbal mixture capsules 700 mg/day and the herbal mixture along with CC for 3 months, respectively. Finally, several related parameters were measured, including the level of sex steroids, homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile (primary outcomes), thyroid hormones, and clinical features. The analysis was based on intention-to-treat analysis. Results: No statistically significant differences were observed between the groups in terms of socio-demographic characteristics. However, after adjustment for baseline, luteinizing hormone (aMD = 4.9; 95% CI: 3.7-6.2), luteinizing hormone/follicle-stimulating hormone (aMD = 0.9; 95% CI: 0.7-1.2), total testosterone (aMD =-0.12; 95% CI:-0.2 to-0.01) in group 2 and free testosterone (aMD =-6.0; 95% CI:-9.7 to-2.3) in group 3 revealed a significant difference compared to group 1. In addition, HOMA-IR in group 2 (aMD =-1.3; 95% CI:-2.4 to-0.2) decreased significantly compared to group 1. Further, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol decreased significantly

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Section: Medicinal Plants and Capsule (700 Mg) Preparation And Standamentioning

confidence: 99%

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Ainehchi

Khaki

Ouladsahebmadarek

et al. 2020

aoms

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“…In addition, a negligible amount of coumarin content is present in C. zeylanicum [ 43 ]. Furthermore, freeze-dried hot water extract of stem bark of C. zeylanicum was subjected to determine its antidiabetic activity via randomized, double-blind, placebo controlled clinical trial carried out for a period of four months in patients with DM [ 81 ]. However, the outcomes of this clinical trial are unavailable to date.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

Wasana

Attanayake

Jayatilaka

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The use of medicinal plant extracts and their isolated bioactive compounds for the management of diabetes mellitus has been tremendously increased in recent decades. The present study aimed at providing in-depth information on medicinal flora that has been widely used in the Sri Lankan traditional healthcare system for the management of diabetes mellitus. The data of this review article were obtained from published articles from January 2000 to September 2020 in scientific databases of PubMed, Web of Science, and Google Scholar. In this review, a total number of 18 medicinal plants with the antidiabetic activity were expressed, and their isolated antidiabetic active compounds were highlighted as new drug leads. Results of the reported studies revealed that medicinal plants exert a potent antidiabetic activity via both in vitro and in vivo study settings. However, bioactive compounds and antidiabetic mechanism (s) of action of many of the reported medicinal plants have not been isolated/elucidated the structure in detail, to date. Reported antidiabetic medicinal plants with other properties such as antioxidant and antihyperlipidemic activities deliver new entities for the development of antidiabetic agents with multiple therapeutic targets. This is a comprehensive review on potential antidiabetic activities of the Sri Lankan medicinal plants that have been widely used in the traditional healthcare system. The information presented here would fill the gap between the use of them by traditional healers in the traditional medicine healthcare system in Sri Lanka and their potency for development of new drug entities in future.

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“…CZB contain major constituent like cinnamaldehyde, benzaldehyde and euginol, among these cinnamaldehyde and euginol show antispasmodic and muscle relaxant action mainly intestinal transit and gastric emptying 16 . It has been uses as antitussive, antiarthritis, antimicrobial 17, 18 , antifungal 19 , antiviral 20 antioxidant 21,22 , antiinflammatory 14 , antidiabetic [23][24][25] antiarrhythmic 15 , anti-atherosclerotic 26 and anticancer 27, 28 . There is a worldwide trend to go back to herbal medicine in the treatment of liver disease as a synthetic drug used in the treatment of liver disease have serious adverse effect 29 .…”

Section: Fig 1: Acetaminophen Metabolismmentioning

confidence: 99%

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2021

IJPSR

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The objective of the current study is to investigate the hepatoprotective activity of Cinnamomum zeylanicum bark (CZB) extract on acetaminophen-induced hepatotoxicity in albino rats. Wistar albino rats (150-200 g) of either sex were divided into six groups, and toxicity was induced by acetaminophen (APAP) at a dose of 750 mg/kg, bw, p.o, every 72 h, for two weeks. Silymarin (100 mg/kg, p.o) was given as reference standard. CZB (100 mg/kg and 200 mg/kg, p.o) was tested for hepatoprotective activity. Various serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP), total Bilirubin (TB), total protein (TP), albumin (ALB), and total cholesterol (TC) in different groups were measured. Further, the effect of the extract on super oxide dismutase, catalase, reduced glutathione, and lipid peroxidation were also estimated. The treatment with ethanolic extract of CZB reduced the elevated levels of AST, ALT, ALP, TB, and TC and also reversed the hepatic damage as compared with toxic control rats. A decreased level of ALB and TP was also significantly restored by CZB pre-treatment. It is also significantly restored the antioxidant level in hepatic tissue. Further CZB treatment also reduced histological alteration induced in the liver. The result suggests that the ethanolic extract of CZB has strong hepatoprotective agents on acetaminophen-induced toxicity in albino rats. INTRODUCTION:The liver is a vital organ that is responsible for the metabolism of endogenous and exogenous agents 1 . It is also called hepatic and made up of hepatocytes, which carried out multiple processes essential for life. It plays an important role in drug elimination and detoxification.

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Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial

Cited by 45 publications

References 28 publications

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

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